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A New Clinical Phenotype with Non-Plexiform Vasculopathy and Distinctive Microvessel Remodeling Among Idiopathic Pulmonary Arterial Hypertension Patients

Autor: E.J. Nossent, J. Smits, C. Seegers, L. Meijboom, A. Boonstra, K. Tran-Lundmark, J. Aman, F. De Man, H.J. Bogaard, T. Radonic, P. Dorfmüller, A. Vonk Noordegraaf

Publikováno v: Nossent, E J, Smits, J, Seegers, C, Meijboom, L, Boonstra, A, Tran-Lundmark, K, Aman, J, De Man, F, Bogaard, H, Radonic, T, Dorfmueller, P & Noordegraaf, A V 2022, ' A New Clinical Phenotype with Non-Plexiform Vasculopathy and Distinctive Microvessel Remodeling Among Idiopathic Pulmonary Arterial Hypertension Patients ', American Journal of Respiratory and Critical Care Medicine, vol. 205, D96 . < https://www.atsjournals.org/doi/epdf/10.1164/ajrccm-conference.2022.205.1_MeetingAbstracts.A5302 >
American Journal of Respiratory and Critical Care Medicine, 205:D96. American Thoracic Society

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b375dc968ceae2040ebba3727f4b9ce2
https://research.vumc.nl/en/publications/2f88a63b-fcfe-4c7c-af3e-a3ef50bf7b61

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Vasculopathy in Idiopathic Pulmonary Arterial Hypertension Patients with a Low DLCO; A Distinctive Entity?

Autor: C. Seegers, A. Vonk Noordegraaf, Esther J. Nossent, Teodora Radonic, Anco Boonstra, Lilian J. Meijboom, J. Smits, Peter Dorfmüller, Herman J Bogaard

Publikováno v: American Journal of Respiratory and Critical Care Medicine, 201. American Thoracic Society
Smits, J, Nossent, E J, Seegers, C, Meijboom, L J, Boonstra, A, Bogaard, H J, Radonic, T, Dorfmuller, P & Vonk Noordegraaf, A 2020, ' Vasculopathy in Idiopathic Pulmonary Arterial Hypertension Patients with a Low DLCO; A Distinctive Entity? ', American Journal of Respiratory and Critical Care Medicine, vol. 201 .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca570d5279981f28095e98739e23316
https://research.vumc.nl/en/publications/b23de76c-f9a9-4304-b1dc-96b7ebad55dc

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Cytotoxic Deoxypodophyllotoxin Can Be Extracted in High Purity from Anthriscus sylvestris Roots by Supercritical Carbon Dioxide

Autor: Wim J. Quax, Christel L. C. Seegers, Rita Setroikromo, Pieter G. Tepper

Publikováno v: Planta Medica, 84(8), 544-550. GEORG THIEME VERLAG KG

Deoxypodophyllotoxin is present in the roots of Anthriscus sylvestris. This compound is cytotoxic on its own, but it can also be converted into podophyllotoxin, which is in high demand as a precursor for the important anticancer drugs etoposide and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38210afd8c83329e704681abfffabb1d
https://research.rug.nl/en/publications/6e6bd06e-8e09-473e-8f31-465df0af2808

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Methyl jasmonate treatment increases podophyllotoxin production in Podophyllum hexandrum roots under glasshouse conditions

Autor: Rita Setroikromo, Peter Horvatovich, Ron Peters, Christel L. C. Seegers, Pieter G. Tepper, Wim J. Quax

Publikováno v: Plant and Soil, 417(1-2), 117-126. SPRINGER

The endangered Podophyllum hexandrum is an important industrial source of podophyllotoxin, which is a precursor for the anticancer drugs etoposide and teniposide. Attempts to obtain podophyllotoxin through cell cultures or chemical synthesis have sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c2bdc5b170073d9a43d2296cc93feb
https://research.rug.nl/en/publications/aed8edfd-b651-4a8f-b5ad-bc1254fa3a78

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Towards Metabolic Engineering of Podophyllotoxin Production

Autor: Christel L. C. Seegers, Wim J. Quax, Rita Setroikromo

Publikováno v: Natural Products and Cancer Drug Discovery

The pharmaceutically important anticancer drugs etoposide and teniposide are derived from podophyllotoxin, a natural product isolated from roots of Podophyllum hexandrum growing in the wild. The overexploitation of this endangered plant has led to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80dbf5bdccbba6570c8dbba2ccaff28b
https://doi.org/10.5772/67615

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A Comparative Study of Ochratoxin A-Induced Apoptosis in Hamster Kidney and HeLa Cells

Autor: J C, Seegers, L H, Böhmer, M C, Kruger, M L, Lottering, M, de Kock

Publikováno v: Toxicology and Applied Pharmacology. 129:1-11

Ochratoxin A (OA), produced by strains of Aspergillus and Penicillium, at a dose of 20 micrograms/ml caused nuclear and nucleolar changes characteristic of apoptosis in hamster kidney (HaK) and HeLa cells. However, the morphological and biochemical l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1601b5fa159d5dc91bce23072ce1557
https://doi.org/10.1006/taap.1994.1222

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Combined effect of bradykinin B2 and neurokinin-1 receptor activation on endothelial cell proliferation in acute synovitis

Autor: Lyane Haywood, Paul S. Avery, Hélène C. Seegers, Daniel F. McWilliams, David A. Walsh

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18(6)

During acute synovitis, early angiogenesis may enhance inflammation by facilitating edema formation and cellular infiltration. We have investigated the in vivo modulation by bradykinin of neurally enhanced early angiogenesis in rat models of knee syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127ac0b2f0f88a16ecdf1dbd8bbf7b98
https://pubmed.ncbi.nlm.nih.gov/14766794

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Calcium-independent phospholipase A(2)-derived arachidonic acid is essential for endothelium-dependent relaxation by acetylcholine

Autor: Walter A. Boyle, Richard W. Gross, Hélène C. Seegers

Publikováno v: The Journal of pharmacology and experimental therapeutics. 302(3)

The role of calcium-independent phospholipase A(2) (iPLA(2))-produced arachidonic acid (AA) in acetylcholine (ACh)-mediated, endothelium-dependent vascular relaxation was investigated. ACh-induced relaxation of phenylephrine-constricted isolated rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a88c0b08573b6f972ad43f6cef3aea6
https://pubmed.ncbi.nlm.nih.gov/12183647

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