Zobrazeno 1 - 10
of 27
pro vyhledávání: '"C. Scott Shultz"'
Autor:
Mark Weisel, Embarek Alwedi, Matthew Chow, Jacob H. Waldman, Eric M. Phillips, Kerstin Zawatzky, Pratiq Patel, Stephen M. Dalby, Stephanus Axnanda, Eric B. Sirota, Michael Whittington, C. Scott Shultz, Xiao Wang, Taotao Lu, Nilusha Padivitage, Jianjun Duan, Tao Wang
Publikováno v:
Organic Process Research & Development. 26:543-550
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c7d957823b0eb16cf67d6a2db0e75a6
https://doi.org/10.1021/acs.oprd.1c00242
https://doi.org/10.1021/acs.oprd.1c00242
Autor:
Nastaran Salehi Marzijarani, Adam J. Fine, Anil R. Ekkati, Zachary E. X. Dance, Samiksha Poudyal, Taylor Behre, Stephen M. Dalby, Rekha Gangam, C. Scott Shultz, Kevin H. Stone, Brittany M. Armstrong
Publikováno v:
Organic Process Research & Development. 26:533-542
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a3ebb45d194c94eb4d71884fdcce804
https://doi.org/10.1021/acs.oprd.1c00231
https://doi.org/10.1021/acs.oprd.1c00231
Autor:
Yong-Li Zhong, C. Scott Shultz, Jacob M. Janey, Yonggang Chen, Birgit Kosjek, Lushi Tan, Jeffrey C. Moore, Michael Shevlin
Publikováno v:
The Journal of Organic Chemistry. 87:2120-2128
Two scalable and efficient synthetic routes for the synthesis of a T-type calcium channel antagonist MK-8998 were developed from a simple pyridine building block. The key step to set the stereochemistry relied on either chiral rhodium catalyst-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4280b753a165445efd097582eba7cf
https://doi.org/10.1021/acs.joc.1c01795
https://doi.org/10.1021/acs.joc.1c01795
Autor:
Richard G. Ball, Narayan Variankaval, Robert A. Reamer, Jaume Balsells, Gregory York, Teresa Andreani, Varsolona Richard J, Jing Li, Andrew Brunskill, Nancy N. Tsou, Jimmy O. DaSilva, Manuel de Lera Ruiz, Nobuyoshi Yasuda, Ryan D. Cohen, C. Scott Shultz
Publikováno v:
Organic Process Research & Development. 19:1882-1890
MK-8970 is an acetal carbonate prodrug of raltegravir (Isentress). This work presents the Merck team’s investigations into the polymorphism of MK-8970, the thermodynamic relationship between the discovered crystalline forms, and implementation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a920d1d1119205fc3919acebe28359f8
https://doi.org/10.1021/acs.oprd.5b00129
https://doi.org/10.1021/acs.oprd.5b00129
Autor:
R. Scott Hoerrner, Juan D. Arredondo, C. Scott Shultz, Takahiro Itoh, Xianghui Wen, Debra J. Wallace, Jason L. Nyrop, Dalian Zhao, Paul G. Bulger, Daniel J. Muzzio, Lushi Tan, Ephraim M. Bassan, Qinghao Chen, Mark Weisel, Sarah J. Dolman, Chengfu Xie, Pintipa Grongsaard
Publikováno v:
Organic Process Research & Development. 16:1069-1081
The development of a convergent, chromatography-free synthesis of an allosteric Akt kinase inhibitor is described. The route comprised 17 total steps and was used to produce kilogram quantities of the target molecule. A key early transformation, for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::317d3d594c7cd2a3aab48392e1bc47ab
https://doi.org/10.1021/op300031r
https://doi.org/10.1021/op300031r
Autor:
C. Scott Shultz, Peter H. Dobbelaar, Ravi P. Nargund, Ronsar Eid, Zhong Lai, Zhixiong Ye, Shuwen He
Publikováno v:
Tetrahedron Letters. 52:3621-3624
Asymmetric hydrogenation of achiral spiroindene dimethyl acetic acid 2 with 4% of Ru(II)-Mandyphos in acetone produced (S)-spiroindane dimethyl acetic acid 1 in 86% isolated yield and 96.8:3.2 enantiomeric ratio.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f378d6ca0977a2dd3fcbfdc6f4911cb
https://doi.org/10.1016/j.tetlet.2011.05.029
https://doi.org/10.1016/j.tetlet.2011.05.029
Autor:
Zhuqing Liu, Edward C. Sherer, Joseph Shpungin, James Cuff, Feng Xu, Claire Lee, Candice A. Sherwood, Shane W. Krska, Richard Desmond, C. Scott Shultz, Peter G. Dormer
Publikováno v:
Tetrahedron Letters. 52:1685-1688
An efficient preparation of highly enantiomerically enriched aryl β-hydroxy α-amino esters via dynamic kinetic resolution (DKR), asymmetric transfer hydrogenation of α-amino β-keto esters is described. The anti β-hydroxyl α-amino esters were ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c11043892d2f730ffbbc59303ea25213
https://doi.org/10.1016/j.tetlet.2011.01.146
https://doi.org/10.1016/j.tetlet.2011.01.146
Publikováno v:
Transition Metal-Catalyzed Couplings in Process Chemistry: Case Studies from the Pharmaceutical Industry
A practical, cost-effective Kumada coupling for the preparation of 4-allylisoindoline has been developed. The first catalyst screen for this reaction with allylmagnesium reagents is described. The challenges associated with product isomerization have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a17b55a4f751be2cf4010c4c7859555
https://doi.org/10.1021/op1002837
https://doi.org/10.1021/op1002837
Autor:
Kevin R. Campos, Felix Spindler, Yongkui Sun, J. Christopher McWilliams, Brian D. Phenix, Cheng-yi Chen, C. Scott Shultz, Shane W. Krska, Brian R. Crump, Artis Klapars, Daniel Zewge, Debra J. Wallace
Publikováno v:
Organic Process Research & Development. 13:84-90
Taranabant (1) is a cannabinoid-1 receptor (CB1R) inverse agonist that was recently in late-stage clinical development for the treatment of obesity. The previously employed synthesis exhibited a number of shortcomings for continuing development, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfed06f435bbfc9582b2848fb40adb6c
https://doi.org/10.1021/op800270e
https://doi.org/10.1021/op800270e
Autor:
Benjamin T. Dorner, John Limanto, Shane W. Krska, C. Scott Shultz, Richard Desmond, Paul N. Devine
Publikováno v:
The Journal of Organic Chemistry. 73:1639-1642
Asymmetric hydrogenation of allylic dimethylcarbinamide 2 with 1 mol % of cationic Rh(I)-Josiphos complex in THF under 500 psi of H2 generated the corresponding tertiary carbinamide 1 in 98.5% assay yield and a 94:6 enantiomeric ratio. Upon crystalli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0787a90c1b0c9ae518398311c92e481d
https://doi.org/10.1021/jo702429u
https://doi.org/10.1021/jo702429u