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Akademický článek

Comparison of Fluorescent Tag DNA Labeling Methods Used for Expression Analysis by DNA Microarrays

Autor: A. Richter, C. Schwager, S. Hentze, W. Ansorge, M.W. Hentze, M. Muckenthaler

Publikováno v: BioTechniques, Vol 33, Iss 3, Pp 620-630 (2002)

Gene expression profiling by DNA microarrays has found wide application in many fields of biomedical research. The protocols for this technique are not yet standardized, and for each given step in microarray analysis a number of different protocols a

Externí odkaz: https://doaj.org/article/7f60a686bc464c3d8f797a742f27dfd3

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Akademický článek

Phenotypically sorted highly and weakly migratory triple negative breast cancer cells exhibit migratory and metastatic commensalism

Autor: Lauren A. Hapach, Wenjun Wang, Samantha C. Schwager, Devika Pokhriyal, Emily D. Fabiano, Cynthia A. Reinhart-King

Publikováno v: Breast Cancer Research, Vol 25, Iss 1, Pp 1-12 (2023)

Abstract Background Intratumor heterogeneity is a well-established hallmark of cancer that impedes cancer research, diagnosis, and treatment. Previously, we phenotypically sorted human breast cancer cells based on migratory potential. When injected i

Externí odkaz: https://doaj.org/article/74f55ca45e284d36a5bce61053d4ab43

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Akademický článek

A patient-designed tissue-engineered model of the infiltrative glioblastoma microenvironment

Autor: R. C. Cornelison, J. X. Yuan, K. M. Tate, A. Petrosky, G. F. Beeghly, M. Bloomfield, S. C. Schwager, A. L. Berr, C. A. Stine, D. Cimini, F. F. Bafakih, J. W. Mandell, B. W. Purow, B. J. Horton, J. M. Munson

Publikováno v: npj Precision Oncology, Vol 6, Iss 1, Pp 1-14 (2022)

Abstract Glioblastoma is an aggressive brain cancer characterized by diffuse infiltration. Infiltrated glioma cells persist in the brain post-resection where they interact with glial cells and experience interstitial fluid flow. We use patient-derive

Externí odkaz: https://doaj.org/article/42c40b9824ab4d4892cb00cdede09d50

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Akademický článek

Matrix stiffness induces epithelial-to-mesenchymal transition via Piezo1-regulated calcium flux in prostate cancer cells

Autor: Maria Lopez-Cavestany, Su Bin Hahn, Jacob M. Hope, Noah T. Reckhorn, Joshua D. Greenlee, Samantha C. Schwager, Jacob A. VanderBurgh, Cynthia A. Reinhart-King, Michael R. King

Publikováno v: iScience, Vol 26, Iss 4, Pp 106275- (2023)

Summary: Cells utilize calcium channels as one of the main signaling mechanisms to sense changes in the extracellular space and convert these changes to intracellular signals. Calcium regulates several key signaling networks, such as the induction of

Externí odkaz: https://doaj.org/article/e150ebe4d8d04bd99f38fa0ec25e62ce

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Akademický článek

Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis

Autor: Samantha C Schwager, Katherine M Young, Lauren A Hapach, Caroline M Carlson, Jenna A Mosier, Tanner J McArdle, Wenjun Wang, Curtis Schunk, Anissa L Jayathilake, Madison E Bates, Francois Bordeleau, Marc A Antonyak, Richard A Cerione, Cynthia A Reinhart-King

Publikováno v: eLife, Vol 11 (2022)

Cancer cell migration is highly heterogeneous, and the migratory capability of cancer cells is thought to be an indicator of metastatic potential. It is becoming clear that a cancer cell does not have to be inherently migratory to metastasize, with w

Externí odkaz: https://doaj.org/article/622c88bf6fa14684a1a8c69fe64f0098

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Akademický článek

Link between glucose metabolism and epithelial-to-mesenchymal transition drives triple-negative breast cancer migratory heterogeneity

Autor: Samantha C. Schwager, Jenna A. Mosier, Reethi S. Padmanabhan, Addison White, Qinzhe Xing, Lauren A. Hapach, Paul V. Taufalele, Ismael Ortiz, Cynthia A. Reinhart-King

Publikováno v: iScience, Vol 25, Iss 10, Pp 105190- (2022)

Summary: Intracellular and environmental cues result in heterogeneous cancer cell populations with different metabolic and migratory behaviors. Although glucose metabolism and epithelial-to-mesenchymal transition have previously been linked, we aim t

Externí odkaz: https://doaj.org/article/b88984cec234459bb1111c2b87caae70

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