Zobrazeno 1 - 10
of 14
pro vyhledávání: '"C. Sahara Khademullah"'
Autor:
C. Sahara Khademullah, Yves De Koninck
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated with the loss of cortical and spinal motor neurons (MNs) and muscle degeneration (Kiernan et al. in Lancet 377:942–955, 2011). In the preclinical setting, funct
Externí odkaz:
https://doaj.org/article/80d63dd6b4c3403c8c023bce4c5c285e
Autor:
Afif J. Aqrabawi, Caleb J. Browne, Zahra Dargaei, Danielle Garand, C. Sahara Khademullah, Melanie A. Woodin, Jun Chul Kim
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
The anterior olfactory nucleus pars medialis (mAON) provides cortical feedback to the olfactory bulb, but the behavioural relevance of these projections is unknown. Here, using opto- and chemogenetic approaches, the authors find the mAON bidirectiona
Externí odkaz:
https://doaj.org/article/25674281bedc4f6ea294e348f220b127
Autor:
Vivek Mahadevan, C Sahara Khademullah, Zahra Dargaei, Jonah Chevrier, Pavel Uvarov, Julian Kwan, Richard D Bagshaw, Tony Pawson, Andrew Emili, Yves De Koninck, Victor Anggono, Matti Airaksinen, Melanie A Woodin
Publikováno v:
eLife, Vol 6 (2017)
KCC2 is a neuron-specific K+-Cl– cotransporter essential for establishing the Cl- gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where it regulates spine morphog
Externí odkaz:
https://doaj.org/article/808ef6f0d5704933a10867aa053d4918
Autor:
Xinyi Liang, Danielle Garand, Iason Keramidis, Julia Keith, Jun Chul Kim, Melanie A. Woodin, C. Sahara Khademullah, Afif J. Aqrabawi, Jessica C. Pressey, Simon Bedard, Kara M Place, Alicja Gasecka, Zahra Dargaei, Lorne Zinman, Janice Robertson, Jy Wei Yang, Daniel Côté, Yves De Koninck
Publikováno v:
Brain. 143:800-810
Amyotrophic lateral sclerosis is a fatal disease resulting from motor neuron degeneration in the cortex and spinal cord. Cortical hyperexcitability is a hallmark feature of amyotrophic lateral sclerosis and is accompanied by decreased intracortical i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c89b6eb8ef404180923f406dca70d7
https://doi.org/10.1093/brain/awaa034
https://doi.org/10.1093/brain/awaa034
Autor:
C. Sahara Khademullah, Zahra Dargaei, Melanie A. Woodin, Pavel Uvarov, Alamjeet K. Chauhan, Jessica C. Pressey, Wenqing Ye, Matti S. Airaksinen, Jonah Chevrier, Michelle Y. Huang, Vivek Mahadevan, Steven J. Meas
Publikováno v:
Journal of Biological Chemistry. 292:6190-6201
Synaptic inhibition depends on a transmembrane gradient of chloride, which is set by the neuron-specific K+-Cl− co-transporter KCC2. Reduced KCC2 levels in the neuronal membrane contribute to the generation of epilepsy, neuropathic pain, and autism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6de690637645defdeed9f91af3fa8b5
https://doi.org/10.1074/jbc.m116.767236
https://doi.org/10.1074/jbc.m116.767236
Autor:
Jun Chul Kim, Zahra Dargaei, Simon Bedard, Jee Yoon Bang, C. Sahara Khademullah, Vivek Mahadevan, Melanie A. Woodin, Gustavo M. Parfitt
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Huntington’s disease (HD) is a fatal neurodegenerative disorder that currently has no cure. Although HD is classically considered a motor disorder, HD patients experience learning and memory deficits years before the onset of motor sym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab73a0da0aec8ed13776c5a4a48e9e3e
https://doi.org/10.1073/pnas.1716871115
https://doi.org/10.1073/pnas.1716871115
Autor:
Julian Kwan, Victor Anggono, Melanie A. Woodin, Vivek Mahadevan, C. Sahara Khademullah, Pavel Uvarov, Matti S. Airaksinen, Jonah Chevrier, Yves De Koninck, Zahra Dargaei, Richard D. Bagshaw, Tony Pawson, Andrew Emili
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
KCC2 is a neuron-specific K+-Cl– cotransporter essential for establishing the Cl- gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where it regulates spine morphog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa8a415f5a6f18c45b46a5562852870
https://doi.org/10.7554/elife.28270
https://doi.org/10.7554/elife.28270
Autor:
C. Sahara Khademullah, Victor Anggono, Richard D. Bagshaw, Jonah Chevrier, Melanie A. Woodin, Vivek Mahadevan, Julian Kwan, Pavel Uvarov, Zahra Dargaei, Matti S. Airaksinen, Andrew Emili, Tony Pawson, Yves De Koninck
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8c1b39ebd44c49b6322264b2415dde1
https://doi.org/10.7554/elife.28270.032
https://doi.org/10.7554/elife.28270.032
Autor:
Melanie A. Woodin, Danielle Garand, Jun Chul Kim, Zahra Dargaei, C. Sahara Khademullah, Caleb J. Browne, Afif J. Aqrabawi
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Olfactory processing is thought to be actively modulated by the top-down input from cortical regions, but the behavioural function of these signals remains unclear. Here we find that cortical feedback from the anterior olfactory nucleus pars medialis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ba431aa893d87964018be41773b145
https://doi.org/10.1038/ncomms13721
https://doi.org/10.1038/ncomms13721
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a270ddc5062535caa4ccd68e0412a5d
https://doi.org/10.1096/fasebj.27.1_supplement.920.9
https://doi.org/10.1096/fasebj.27.1_supplement.920.9