Zobrazeno 1 - 10
of 338
pro vyhledávání: '"C. SKAAR"'
Autor:
Nicholas R. Powell, Tyler Shugg, Jacob Leighty, Matthew Martin, Rolf P. Kreutz, Michael T. Eadon, Dongbing Lai, Tao Lu, Todd C. Skaar
Publikováno v:
Chronic Diseases and Translational Medicine, Vol 10, Iss 2, Pp 102-117 (2024)
Abstract Background Hypertension (HTN) involves genetic variability in the renin‐angiotensin system and influences antihypertensive response. We previously reported that angiotensinogen (AGT) messenger RNA (mRNA) is endogenously bound by miR‐122
Externí odkaz:
https://doaj.org/article/3ddeee81c38249dfbeaa61315455683e
Autor:
Todd C. Skaar, Rachel A. Myers, Roger B. Fillingim, John T. Callaghan, Emily Cicali, Michael T. Eadon, Erica N. Elwood, Geoffrey S. Ginsburg, Sheryl Lynch, Khoa A. Nguyen, Aniwaa Owusu Obeng, Haesuk Park, Victoria M. Pratt, Marc Rosenman, Azita Sadeghpour, Saskia Shuman, Rajbir Singh, Emma M. Tillman, Simona Volpi, Kristin Wiisanen, Almut G. Winterstein, Carol R. Horowitz, Deepak Voora, Lori Orlando, Hrishikesh Chakraborty, Sara Van Driest, Josh F. Peterson, Larisa A. Cavallari, Julie A. Johnson, Paul R. Dexter, the IGNITE Pragmatic Trials Network
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 8, Pp n/a-n/a (2024)
Abstract Chronic pain is a prevalent condition with enormous economic burden. Opioids such as tramadol, codeine, and hydrocodone are commonly used to treat chronic pain; these drugs are activated to more potent opioid receptor agonists by the hepatic
Externí odkaz:
https://doaj.org/article/56442bcb216e492ab0211fa40c8e5b76
Autor:
Lindsay J. Hines, Russell A. Wilke, Rachel Myers, Carol A. Mathews, Michelle Liu, Jordan F. Baye, Natasha Petry, Emily J. Cicali, Benjamin Q. Duong, Erica Elwood, Leslie Hulvershorn, Khoa Nguyen, Michelle Ramos, Azita Sadeghpour, R. Ryanne Wu, Lloyda Williamson, Kristin Wiisanen, Deepak Voora, Rajbir Singh, Kathryn V. Blake, James W. Murrough, Simona Volpi, Geoffrey S. Ginsburg, Carol R. Horowitz, Lori Orlando, Hrishikesh Chakraborty, Paul Dexter, Julie A. Johnson, Todd C. Skaar, Larisa H. Cavallari, Sara L. Van Driest, Josh F. Peterson, the IGNITE Pragmatic Trials Network
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 6, Pp n/a-n/a (2024)
Abstract Specific selective serotonin reuptake inhibitors (SSRIs) metabolism is strongly influenced by two pharmacogenes, CYP2D6 and CYP2C19. However, the effectiveness of prospectively using pharmacogenetic variants to select or dose SSRIs for depre
Externí odkaz:
https://doaj.org/article/924b2d238fd2492abe1558654120a8ef
Autor:
Nicholas R. Powell, Tiebing Liang, Joseph Ipe, Sha Cao, Todd C. Skaar, Zeruesenay Desta, Hui-Rong Qian, Philip J. Ebert, Yu Chen, Melissa K. Thomas, Naga Chalasani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
This study characterizes expression of pharmacogenes across the histological NAFLD severity spectrum. Here, the authors show the downregulation of CYP2C19 in NAFLD which supports developing personalized medicine approaches for drugs sensitive to meta
Externí odkaz:
https://doaj.org/article/a90be45cc8cb455db34c7afe0b5d1181
Autor:
Larisa H. Cavallari, Emily Cicali, Kristin Wiisanen, Roger B. Fillingim, Hrishikesh Chakraborty, Rachel A. Myers, Kathryn V. Blake, Bolanle Asiyanbola, Jordan F. Baye, Wesley H. Bronson, Kelsey J. Cook, Erica N. Elwood, Chancellor F. Gray, Yan Gong, Lindsay Hines, Joseph Kannry, Natalie Kucher, Sheryl Lynch, Khoa A. Nguyen, Aniwaa Owusu Obeng, Victoria M. Pratt, Hernan A. Prieto, Michelle Ramos, Azita Sadeghpour, Rajbir Singh, Marc Rosenman, Petr Starostik, Cameron D. Thomas, Emma Tillman, Paul R. Dexter, Carol R. Horowitz, Lori A. Orlando, Josh F. Peterson, Todd C. Skaar, Sara L. Van Driest, Simona Volpi, Deepak Voora, Hari K. Parvataneni, Julie A. Johnson, for the IGNITE Pragmatic Trials Network
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 10, Pp 2479-2492 (2022)
Abstract Opioid prescribing for postoperative pain management is challenging because of inter‐patient variability in opioid response and concern about opioid addiction. Tramadol, hydrocodone, and codeine depend on the cytochrome P450 2D6 (CYP2D6) e
Externí odkaz:
https://doaj.org/article/45b2d593bd564fc0a4c8524c8e05af02
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 8, Pp 1946-1958 (2022)
Abstract MicroRNAs (miRNAs) are small RNAs integral in the regulation of gene expression. Analysis of circulating miRNA levels may identify patients with coronary artery disease (CAD) at risk for recurrent myocardial infarction (MI) after percutaneou
Externí odkaz:
https://doaj.org/article/fba3b64bf7a140a8aad06bcb18ca1359
Autor:
Tyler Shugg, Reynold C. Ly, Wilberforce Osei, Elizabeth J. Rowe, Caitlin A. Granfield, Ty C. Lynnes, Elizabeth B. Medeiros, Jennelle C. Hodge, Amy M. Breman, Bryan P. Schneider, S. Cenk Sahinalp, Ibrahim Numanagić, Benjamin A. Salisbury, Steven M. Bray, Ryan Ratcliff, Todd C. Skaar
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundNext-generation sequencing (NGS), including whole genome sequencing (WGS) and whole exome sequencing (WES), is increasingly being used for clinic care. While NGS data have the potential to be repurposed to support clinical pharmacogenomics
Externí odkaz:
https://doaj.org/article/0e19f26f16c14c318fbd190942dc1299
Autor:
Ramzi G. Salloum, Jeffrey R. Bishop, Amanda L. Elchynski, D. Max Smith, Elizabeth Rowe, Kathryn V. Blake, Nita A. Limdi, Christina L. Aquilante, Jill Bates, Amber L. Beitelshees, Amber Cipriani, Benjamin Q. Duong, Philip E. Empey, Christine M. Formea, J. Kevin Hicks, Pawel Mroz, David Oslin, Amy L. Pasternak, Natasha Petry, Laura B. Ramsey, Allyson Schlichte, Sandra M. Swain, Kristen M. Ward, Kristin Wiisanen, Todd C. Skaar, Sara L. Van Driest, Larisa H. Cavallari, Sony Tuteja
Publikováno v:
Implementation Science Communications, Vol 3, Iss 1, Pp 1-9 (2022)
Abstract Background Despite the increased demand for pharmacogenetic (PGx) testing to guide antidepressant use, little is known about how to implement testing in clinical practice. Best–worst scaling (BWS) is a stated preferences technique for dete
Externí odkaz:
https://doaj.org/article/622e160da30149b7bb83516b31e629d0
Autor:
Sony Tuteja, Ramzi G. Salloum, Amanda L. Elchynski, D. Max Smith, Elizabeth Rowe, Kathryn V. Blake, Nita A. Limdi, Christina L. Aquilante, Jill Bates, Amber L. Beitelshees, Amber Cipriani, Benjamin Q. Duong, Philip E. Empey, Christine M. Formea, J. Kevin Hicks, Pawel Mroz, David Oslin, Amy L. Pasternak, Natasha Petry, Laura B. Ramsey, Allyson Schlichte, Sandra M. Swain, Kristen M. Ward, Kristin Wiisanen, Todd C. Skaar, Sara L. Van Driest, Larisa H. Cavallari, Jeffrey R. Bishop, for the IGNITE Pharmacogenetics Working Group
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 2, Pp 371-383 (2022)
Abstract There is growing interest in utilizing pharmacogenetic (PGx) testing to guide antidepressant use, but there is lack of clarity on how to implement testing into clinical practice. We administered two surveys at 17 sites that had implemented o
Externí odkaz:
https://doaj.org/article/8db7d4a68b104a13ba4ac33d91a1855f
Autor:
Nicholas R. Powell, Rebecca M. Silvola, John S. Howard, Sunil Badve, Todd C. Skaar, Joseph Ipe
Publikováno v:
Cancer Reports, Vol 6, Iss 1, Pp n/a-n/a (2023)
Abstract Background Chemotherapeutic drug concentrations vary across different regions of tumors and this is thought to be involved in development of chemotherapy resistance. Insufficient drug delivery to some regions of the tumor may be due to spati
Externí odkaz:
https://doaj.org/article/8bf95053c85c4e7b9fec94e8dd3e68d8