Výsledky vyhledávání - "C. S. McFarlane"

A series of non-quinoline cysLT1 receptor antagonists: Sar study on pyridyl analogs of singulair®

Autor: C. S. Mcfarlane, Robert Zamboni, C. Rochette, M. McAuliffe, Claude Dufresne, P. Prasit, Jacques-Yves Gauthier, Nicole Sawyer, P. Roy, Kathleen M. Metters, Thomas R. Jones, Daniel Guay

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 8:453-458

The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singulair) is described. This work has led to the identification of a number of potent and orally active cysLT1 receptor (LTD4 receptor) antagonists in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd676ec687126fd854a185ba05701c3
https://doi.org/10.1016/s0960-894x(98)00051-1

Zobrazit plný text záznamu

Effects of a selective phosphodiesterase IV inhibitor (CDP-840) in a leukotriene-dependent non-human primate model of allergic asthma

Autor: H. Piechuta, Dwight Macdonald, Ian W. Rodger, C. S. Mcfarlane, M. McAuliffe, Thomas R. Jones

Publikováno v: Canadian Journal of Physiology and Pharmacology. 76:210-217

The activity of CDP-840, a novel, selective phosphodiesterase IV inhibitor was determined in a leukotriene-dependent non-human primate model of allergic asthma. Measurements of specific airway resistance (sRaw) were recorded in a dual chamber plethys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15288a7e83c3e2bc85470c1eb136b4f0
https://doi.org/10.1139/y98-030

Zobrazit plný text záznamu

Discovery of L-740,515, a potent thienopyridine cysLT1 receptor (LTD4 receptor) antagonist

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:2551-2556

Structure-activity studies leading to the discovery of a new series of non-quinoline cysLT 1 receptor (LTD 4 receptor) antagonists are described. These studies demonstrated that the quinoline ring system of montelukast ( 5 ) may be replaced by an app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::205a495753e4e61eaaa19bad61cf9e8e
https://doi.org/10.1016/0960-894x(95)00448-3

Zobrazit plný text záznamu

Evolution of a series of non-quinoline leukotriene D4 receptor antagonist; synthesis and sar of benzothiazoles and thiazoles substituted benzyl alcohols as potent LTD4 antagonists

Autor: C. Rochette, Robert Zamboni, Anthony W. Ford-Hutchinson, Claude Dufresne, Marc Labelle, Deborah Slipetz, C. S. Mcfarlane, Thomas R. Jones, Yves Gareau, Lau Cheuk-Kun, Robert N. Young, L. Charette, Kathleen M. Metters, M. McAuliffe, Nicole Sawyer

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:1615-1620

Replacement of the quinoline pharmacophore of verlukast by alkylthiazoles and benzothiazoles has lead to the discovery of a new series of potent and orally active LTD4 receptor antagonists. The synthesis and structure activity relationships of this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51c83f99b1039f9d62371191466a6878
https://doi.org/10.1016/0960-894x(95)00265-u

Zobrazit plný text záznamu

Pharmacology of montelukast sodium (Singulair™), a potent and selective leukotriene D4 receptor antagonist

Publikováno v: Canadian Journal of Physiology and Pharmacology. 73:191-201

Montelukast sodium (Singulair™), also known as MK-0476 (1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)-ethenyl)phenyl)(3-2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane) acetic acid sodium salt, is a potent and selective inhibitor of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6921a19999723f662391309297b826b0
https://doi.org/10.1139/y95-028

Zobrazit plný text záznamu

Discovery of MK-0476, a potent and orally active leukotriene D4 receptor antagonist devoid of peroxisomal enxyme induction

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:283-288

Structure-activity studies leading to the discovery of 1 (MK-0476) are described. The initial compound of this series, 2, was a potent leukotriene D4 (LTD4) antagonist, but was also a peroxisomal enzyme inducer in the mouse. Structure-activity relati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c50b718bf583613b2d7f8f42c53e3227
https://doi.org/10.1016/0960-894x(95)00023-m

Zobrazit plný text záznamu

Thiopyrano[2,3,4-cd]indoles as 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Resolution of 2-[2-[1-(4-Chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic Acid

Autor: John H. Hutchinson, Carole Lepine, Jean-Pierre Falgueyret, C. Chan, Christine Brideau, C. S. Mcfarlane, Jocelyne Guay, Dwight Macdonald, Thomas R. Jones, Denis Riendeau

Publikováno v: Journal of Medicinal Chemistry. 37:1153-1164

Leukotriene biosynthesis inhibitors have potential as new therapies for asthma and inflammatory diseases. The recently disclosed thiopyrano[2,3,4-cd]indole class of 5-lipoxygenase (5-LO) inhibitors has been investigated with particular emphasis on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d53ca9f3e8a19b6806bd8f65e32a3cb
https://doi.org/10.1021/jm00034a013

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání