Zobrazeno 1 - 10
of 212
pro vyhledávání: '"C. Ryan Miller"'
Autor:
Prachi Bajpai, Sumit Agarwal, Farrukh Afaq, Sameer Al Diffalha, Darshan S. Chandrashekar, Hyung-Gyoon Kim, Abigail Shelton, C. Ryan Miller, Santosh K. Singh, Rajesh Singh, Sooryanarayana Varambally, Ganji Purnachandra Nagaraju, Ashish Manne, Ravi Paluri, Moh’d Khushman, Upender Manne
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)
Abstract Background Treatment with regorafenib, a multiple-kinase inhibitor, to manage metastatic colorectal cancers (mCRCs) shows a modest improvement in overall survival but is associated with severe toxicities. Thus, to reduce regorafenib-induced
Externí odkaz:
https://doaj.org/article/0aee3c95ec79417fba66f7c7f7661819
Autor:
Xing Cheng, Jing An, Jitong Lou, Qisheng Gu, Weimin Ding, Gaith Nabil Droby, Yilin Wang, Chenghao Wang, Yanzhe Gao, Jay Ramanlal Anand, Abigail Shelton, Andrew Benson Satterlee, Breanna Mann, Yun-Chung Hsiao, Chih-Wei Liu, Kun Lu, Shawn Hingtgen, Jiguang Wang, Zhaoliang Liu, C. Ryan Miller, Di Wu, Cyrus Vaziri, Yang Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Almost all Glioblastoma (GBM) are either intrinsically resistant to the chemotherapeutical drug temozolomide (TMZ) or acquire therapy-induced mutations that cause chemoresistance and recurrence. The genome maintenance mechanisms responsible
Externí odkaz:
https://doaj.org/article/30b03460503c40948e61ba53f8ff91ba
Autor:
Pravin Kesarwani, Shiva Kant, Yi Zhao, Antony Prabhu, Katie L. Buelow, C. Ryan Miller, Prakash Chinnaiyan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The upstream metabolism of tryptophan has been described as a metabolic node in glioblastoma. Here the authors show that the downstream metabolism of tryptophan, resulting in the accumulation of quinolinate in glioblastoma, contributes to pro-tumorig
Externí odkaz:
https://doaj.org/article/32c755725f2f4c8ea8e1e1e537931158
Autor:
Aran Merati, Spandana Kotian, Alexus Acton, William Placzek, Erin Smithberger, Abigail K. Shelton, C. Ryan Miller, Josh L. Stern
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13688 (2023)
Glioblastoma (GBM) remains an incurable disease with an extremely high five-year recurrence rate. We studied apoptosis in glioma stem cells (GSCs) in response to HDAC inhibition (HDACi) combined with MEK1/2 inhibition (MEKi) or BCL-2 family inhibitor
Externí odkaz:
https://doaj.org/article/05ba987375ae444995b4beb91d5aa079
Autor:
Sajina GC, Kaysaw Tuy, Lucas Rickenbacker, Robert Jones, Asmi Chakraborty, C. Ryan Miller, Elizabeth A. Beierle, Vidya Sagar Hanumanthu, Anh N. Tran, James A. Mobley, Susan L. Bellis, Anita B. Hjelmeland
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
One of the least-investigated areas of brain pathology research is glycosylation, which is a critical regulator of cell surface protein structure and function. β-Galactoside α2,6-sialyltransferase (ST6GAL1) is the primary enzyme that α2,6 sialylat
Externí odkaz:
https://doaj.org/article/cf92d181c1a04f8787c7b10cecb716a3
Autor:
Hasibur Rehman, Darshan S. Chandrashekar, Chakravarthi Balabhadrapatruni, Saroj Nepal, Sai Akshaya Hodigere Balasubramanya, Abigail K. Shelton, Kasey R. Skinner, Ai-Hong Ma, Ting Rao, Sumit Agarwal, Marie-Lisa Eich, Alyncia D. Robinson, Gurudatta Naik, Upender Manne, George J. Netto, C. Ryan Miller, Chong-xian Pan, Guru Sonpavde, Sooryanarayana Varambally, James E. Ferguson III
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Metastatic urothelial carcinoma is generally incurable with current systemic therapies. Chromatin modifiers are frequently mutated in bladder cancer, with ARID1A-inactivating mutations present in about 20% of tumors. EZH2, a histone methyltransferase
Externí odkaz:
https://doaj.org/article/8e79799b8d1942819fca44a09858150e
Autor:
Christian T. Stackhouse, Joshua C. Anderson, Zongliang Yue, Thanh Nguyen, Nicholas J. Eustace, Catherine P. Langford, Jelai Wang, James R. Rowland IV, Chuan Xing, Fady M. Mikhail, Xiangqin Cui, Hasan Alrefai, Ryan E. Bash, Kevin J. Lee, Eddy S. Yang, Anita B. Hjelmeland, C. Ryan Miller, Jake Y. Chen, G. Yancey Gillespie, Christopher D. Willey
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Key molecular regulators of acquired radiation resistance in recurrent glioblastoma (GBM) are largely unknown, with a dearth of accurate preclinical models. To address this, we generated 8 GBM patient-derived xenograft (PDX) models of acquired radiat
Externí odkaz:
https://doaj.org/article/f06e9a8597724e01bcfa17bb759ec86f
Autor:
Zainab Shonibare, Mehri Monavarian, Kathleen O’Connell, Diego Altomare, Abigail Shelton, Shubham Mehta, Renata Jaskula-Sztul, Rebecca Phaeton, Mark D. Starr, Regina Whitaker, Andrew Berchuck, Andrew B. Nixon, Rebecca C. Arend, Nam Y. Lee, C. Ryan Miller, Nadine Hempel, Karthikeyan Mythreye
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111066- (2022)
Summary: Growth factors in tumor environments are regulators of cell survival and metastasis. Here, we reveal the dichotomy between TGF-β superfamily growth factors BMP and TGF-β/activin and their downstream SMAD effectors. Gene expression profilin
Externí odkaz:
https://doaj.org/article/20e1a0843b1f45028091a733956f68ac
Publikováno v:
Cancers, Vol 14, Iss 22, p 5550 (2022)
Glioblastoma (GBM) represents an aggressive and immune-resistant cancer. Preclinical investigations have identified anti-tumor activity of a ketogenic diet (KD) potentially being used to target GBM’s glycolytic phenotype. Since immune cells in the
Externí odkaz:
https://doaj.org/article/8ebfbf4e9aec47708d897602daca68f8
Autor:
Carla Danussi, Promita Bose, Prasanna T. Parthasarathy, Pedro C. Silberman, John S. Van Arnam, Mark Vitucci, Oliver Y. Tang, Adriana Heguy, Yuxiang Wang, Timothy A. Chan, Gregory J. Riggins, Erik P. Sulman, Frederick F. Lang, Chad J. Creighton, Benjamin Deneen, C. Ryan Miller, David J. Picketts, Kasthuri Kannan, Jason T. Huse
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/23519f12f351443dabd9173f3e5f56f7