Zobrazeno 1 - 10
of 126
pro vyhledávání: '"C. Rubat"'
Autor:
C. Rubat, Pascal Coudert
Publikováno v:
Actualités Pharmaceutiques. 50:23-28
Publikováno v:
Journal of Pharmacy and Pharmacology. 53:1117-1123
A new series of N-substituted dioxo-imidazo[3,4-c]thiazoles have been prepared and evaluated for their analgesic activity. The structures of these new derivatives were confirmed by IR, 1H NMR and 13C NMR spectra, and by elemental analysis. When admin
Publikováno v:
Pharmacy and Pharmacology Communications. 6:387-396
A new series of 4,6-diaryl pyridazin-3-ones substituted on the nitrogen atom in the 2-position have been prepared and evaluated for their analgesic activity in the phenylbenzo-quinone-induced abdominal constriction test. Most of the eighteen compound
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:655-659
A new series of 4.6-diaryl pyridazines substituted in the 3-position by arylpiperazinyl moieties was synthesized and evaluated for analgesic activity. Five out of the nine tested compounds possessed significant antinociceptive effects in the phenylbe
Publikováno v:
Annales pharmaceutiques francaises. 58(4)
The synthesis of 44 original amide derivatives of benzylpiperazine and some analogues of befuraline and piberaline is reported. All compounds have been tested as antidepressive agents. According to the tests, amides 1, 24 and mainly 31 (dihydrobefura
Publikováno v:
Arzneimittel-Forschung. 48(12)
The synthesis and spectral data of some new cyclohexane-2-spiro-[2,5-dihydro-3-(N-arylpiperazin-1-yl-carbonyl) -4-methyl- 5-oxo]furanes are reported. These compounds were subjected to pharmacological tests for evaluation of antinociceptive effects an
Autor:
Danielle Vallee-Goyet, Stéphane Moreau, Daniel Gardette, Jean-Claude Gramain, J. Couquelet, Pascal Coudert, C. Rubat
Publikováno v:
Bioorganicmedicinal chemistry. 6(7)
Analogues of 3-amino-7-(2,6-dichlorobenzyl)-6-methyltriazolo[4,3-b]pyridazine PC25 containing amide or carboxylic acid function were synthesized and tested for anticonvulsant activity. The compounds having the imidazole ring substituted with an amide
Publikováno v:
The Journal of pharmacy and pharmacology. 49(10)
The antinociceptive and antidepressant effects of two pyrazolotriazine derivatives, 2-phenyl-3,3α-dihydro-4-oxo-5-(4-phenylpiperazin-1-yl)methyl-pyrazolo[1,5-d][1,2,4]-triazine (SMI) and 2-phenyl-3,3α-dihydro-4-oxo-5-[4-(4-fluorophenyl)piperazin-1-
Publikováno v:
Arzneimittel-Forschung. 46(8)
A series of 3-arylpiperazinyl-5-benzyl-pyridazines was synthesized and evaluated for analgesic activity. The structures of these new pyridazine derivatives were confirmed by IR, 1H-NMR spectra and by elementary analysis. With ED50 values ranging from
Publikováno v:
Journal de pharmacie de Belgique. 50(5)
The main focus of this review is the pharmacology and the therapeutic use of chemical related agents, the arylpiperazine derivatives. These compounds produce a variety of behavioural responses and pharmacological effects which directly and principall