Zobrazeno 1 - 10
of 15
pro vyhledávání: '"C. Rouzer"'
Publikováno v:
Biochemical Pharmacology. 41:1365-1373
Detailed studies of the interaction of L-656,224 (2-[(4'-methoxyphenyl)methyl]-3-methyl-4-hydroxy-5-propyl-7- chlorobenzofuran) with 5-lipoxygenase were conducted using the enzymes from human and pig leukocytes. L-656,224 was a potent inhibitor of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6620640723b9ac1266b21ebd12c2dfe6
https://doi.org/10.1016/0006-2952(91)90110-q
https://doi.org/10.1016/0006-2952(91)90110-q
Autor:
John A. Rodkey, Jilly F. Evans, John W. Gillard, Sharon Sadowski, Irving S. Sigal, Peter Charleson, Philip J. Vickers, Catherine D. Strader, Rejean Fortin, Anthony W. Ford-Hutchinson, Richard A. F. Dixon, Jacques Yves Gauthier, C. Leveillé, Joseph A. Mancini, C. Rouzer, Ronda Rosen, Douglas K. Miller
Publikováno v:
Nature. 343:278-281
Several inflammatory diseases, including asthma, arthritis and psoriasis are associated with the production of leukotrienes by neutrophils, mast cells and macrophages. The initial enzymatic step in the formation of leukotrienes is the oxidation of ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e53c6cabda5ad0d545496d3831e30d
https://doi.org/10.1038/343278a0
https://doi.org/10.1038/343278a0
Publikováno v:
Journal of Biological Chemistry. 265:1436-1442
Recently, we have shown that ionophore activation of human leukocytes results in leukotriene synthesis and a translocation of 5-lipoxygenase from the cytosol to cellular membrane. This membrane translocation was postulated to be an important early ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30197df7a20297d7f47ddf559f4d2db3
https://doi.org/10.1016/s0021-9258(19)40034-3
https://doi.org/10.1016/s0021-9258(19)40034-3
Autor:
Stella Charleson, C.B. Pickett, Denis Riendeau, Philip J. Vickers, William M. Abraham, Robert N. Young, Philip Tagari, Rejean Fortin, Christine Brideau, Joseph A. Mancini, Petpiboon Prasit, Jocelyne Guay, John H. Hutchinson, John W. Gillard, T. R. Jones, H. Piechuta, Deschenes Denis, Anthony W. Ford-Hutchinson, Jillian F. Evans, C. S. Mcfarlane, C. Rouzer, Diane Guevremont, Serge Leger, Chi-Chung Chan
Publikováno v:
Canadian journal of physiology and pharmacology. 70(6)
MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)-indol-2-yl]-2,2-dimethyl propanoic acid, previously L-686,708) is a potent inhibitor of leukotriene (LT) biosynthesis in intact human and elicited rat polymorphonuclear leukocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a19fd9059bb9430e9e1b85b07528b58
https://pubmed.ncbi.nlm.nih.gov/1330258
https://pubmed.ncbi.nlm.nih.gov/1330258
Autor:
Pierre Hamel, Yvan Guindon, A. Lord, Douglas K. Miller, Anthony W. Ford-Hutchinson, C. Leveillé, John W. Gillard, Jillian F. Evans, Rejean Fortin, Christiane Yoakim, Diane Ethier, Richard A. F. Dixon, C. Rouzer, Howard E. Morton, Yves Girard, Thomas R. Jones
Publikováno v:
Side-Effects of Anti-Inflammatory Drugs 3 ISBN: 9789401053259
Two approaches toward developing anti-leukotriene therapy have led to clinical candidates at the present time. Specific potent leukotriene antagonists (MK-571 [2], MK-679 and ICI-204,219 [3]) have entered clinical trials for asthma and display effica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04997ad51f6920afa1118e5eb53c1305
https://doi.org/10.1007/978-94-011-2982-4_33
https://doi.org/10.1007/978-94-011-2982-4_33
Autor:
Rejean Fortin, C. Chan, H. Piechuta, S. S. Pong, D. Denis, DeHaven Rn, Joshua Rokach, Howard E. Morton, Hollis R. Williams, Larry Peterson, Stella Charleson, C. Rouzer, L. Charette, E. Champion, Thomas R. Jones, Robert Zamboni, Joe Metzger, Denis Riendeau, S. L. Hopple, C. S. Mcfarlane, G. Eiermann, Jillian F. Evans, Roger Meurer, Robert N. Young, T. Bach, Richard Frenette, A. Foster, L. Hupe, John L. Humes, Silvi Luell, Douglas K. Miller, E. E. Opas, Serge Leger, C. Leveillé, Y. Guidon, Jacques-Yves Gauthier, Richard A. F. Dixon, Anthony W. Ford-Hutchinson, P. Masson, A. Lord, Yves Girard, Diane Ethier, M. Belley, John W. Gillard, Pierre Hamel, D. E. Mc McIntyre, Christiane Yoakim, M. Barth, Stephen G. Pacholok
Publikováno v:
Asthma Treatment ISBN: 9781461365259
The peptide leukotrienes LTC4, D4 and E4 collectively account for the biological activity known as slow-reacting substance of anaphylaxis (SRS-A). These metabolites of arachidonic acid are thought to play a role in lung pathophysiology. A role in ast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0845cec71fa4977069e37196521ef540
https://doi.org/10.1007/978-1-4615-3446-4_8
https://doi.org/10.1007/978-1-4615-3446-4_8
Autor:
John Scheigetz, C. S. Mcfarlane, Euan Macintyre, P. H. Gale, Roger Meurer, Alan L. Maycock, C. Dufresne, Joshua Rokach, C. K. Lau, A. L. Dollob, L.G. Letts, T. Bach, H. Piechuta, Douglas K. Miller, Silvi Luell, Yvan Guindon, C. Rouzer, Anthony W. Ford-Hutchinson, Denis Riendeau, S. L. Hopple, Patrice C. Belanger
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 65:2441-2448
L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3-methyl-5-propyl-4-benzofuranol) was a potent inhibitor of leukotriene biosynthesis in intact rat and human leukocytes and CXBG mastocytoma cells (IC50 values, 18–240 nM) and of crude human leukocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e9ad37bfe37ad289156d26d0e2c814
https://doi.org/10.1139/y87-387
https://doi.org/10.1139/y87-387
Autor:
H. Piechuta, Claude Dufresne, Yvan Guindon, Joshua Rokach, T. Bach, John Scheigetz, Euan Macintyre, C. Rouzer, Anthony W. Ford-Hutchinson, Roger Meurer, Silvi Luell, L.G. Letts, Lau Cheuk-Kun, Denis Riendeau, S. L. Hopple, C. S. Mcfarlane, Douglas K. Miller, Patrice C. Belanger, Alan L. Maycock, Hollis R. Williams, D. Denis, P. H. Gale, Aimee Dallob
Publikováno v:
ChemInform. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0e96e593d6afcf870dc1eb1f29543c0
https://doi.org/10.1002/chin.198949139
https://doi.org/10.1002/chin.198949139
Autor:
B. O. M. Vanderborght, C. Rouzere, C. F. Ginuino, G. Maertens, H. Van Heuverswyn, C. F. T. Yoshida
Publikováno v:
Revista do Instituto de Medicina Tropical de São Paulo, Vol 37, Iss 1, Pp 75-79 (1995)
Nearly 400 hemodialysis patients treated at 5 different hemodialysis units in Rio de Janeiro were tested for one year for the presence of hepatitis C and B markers. During the same period, samples were also obtained from 35 continuous ambulatory peri
Externí odkaz:
https://doaj.org/article/15f8b7b1cbb44bfe823b7f883f8fcbbd