Výsledky vyhledávání - "C. Robert Prostko"

Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase

Autor: Toni Gestone Parmer, F. Joseph Germino, Maxim V. Dorovkov, Hediye Erdjument-Bromage, Charmaine E. Mendola, Paul Tempst, Michael D. Ward, Karen S. Pavur, William N. Hait, C. Robert Prostko, Martin Wiedmann, Alexey G. Ryazanov

Publikováno v: Proceedings of the National Academy of Sciences. 94:4884-4889

The several hundred members of the eukaryotic protein kinase superfamily characterized to date share a similar catalytic domain structure, consisting of 12 conserved subdomains. Here we report the existence and wide occurrence in eukaryotes of a prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd2c335f11cc07c650b340b66442f6a
https://doi.org/10.1073/pnas.94.10.4884

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Inhibition of Translational Initiation by Activators of the Glucose-regulated Stress Protein and Heat Shock Protein Stress Response Systems

Autor: Randal J. Kaufman, Margaret A. Brostrom, Charles O. Brostrom, C. Robert Prostko

Publikováno v: Journal of Biological Chemistry. 271:24995-25002

Depletion of endoplasmic reticulum (ER) Ca2+ perturbs protein folding and processing within the organelle while inhibiting translational initiation through activation of the double-stranded RNA-activated eukaryotic initiation factor (eIF)-2alpha kina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f46e78c10ad33b3c8538b16f5c1c523
https://doi.org/10.1074/jbc.271.40.24995

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Activation of the double-stranded RNA-regulated protein kinase by depletion of endoplasmic reticular calcium stores

Autor: Jaydev N. Dholakia, Charles O. Brostrom, C. Robert Prostko, Margaret A. Brostrom

Publikováno v: The Journal of biological chemistry. 270(11)

Perturbants of the endoplasmic reticulum (ER), including Ca(2+)-mobilizing agents, provoke a rapid suppression of translational initiation in conjunction with an increased phosphorylation of the alpha-subunit of eukaryotic initiation factor (eIF)-2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d014c1994a32e803b164f0c7af4ca1ea
https://pubmed.ncbi.nlm.nih.gov/7890757

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Independent signaling of grp78 gene transcription and phosphorylation of eukaryotic initiator factor 2 alpha by the stressed endoplasmic reticulum

Autor: Debra Gmitter, Margaret A. Brostrom, C. Robert Prostko, Charles O. Brostrom

Publikováno v: The Journal of biological chemistry. 270(8)

Perturbation of endoplasmic reticular (ER) function signals increased expression of the gene encoding the ER resident chaperone Grp78/BiP and rapid suppression of translational initiation accompanied by phosphorylation of the alpha-subunit of eukaryo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc63fce577f803780c7bfdd6dac688be
https://pubmed.ncbi.nlm.nih.gov/7876163

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