Zobrazeno 1 - 10
of 15
pro vyhledávání: '"C. Richard Lyons"'
Autor:
Donna F. Kusewitt, Brian Hjelle, Robert A. Nofchissey, Julene Moore, C. Richard Lyons, Diane Goade, John Kreisel
Publikováno v:
Photochemistry and Photobiology. 74:108-114
We have developed a model of cutaneous herpes simplex virus-1 (HSV-1) reactivation in SKH-1 hairless mice which closely mimics the condition in humans. Sixty plaque-forming units of HSV-1 strain 17 syn+ were applied to a superficially abraded area on
Autor:
Yusen Liu, Tamara L. Young, C. Richard Lyons, Kate P. Stanley, Louis G. Chicoine, Kristina M. Reber, Leif D. Nelin
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L298-L306
Nitric oxide (NO) is a vasodilator produced from l-arginine (l-Arg) by NO synthase (NOS). Gene therapy for hypertensive disorders has been proposed using the inducible isoform of NOS (iNOS). l-Arg also can be metabolized to urea and l-ornithine (l-Or
Autor:
Steven Saenz, C. Richard Lyons, Joelle Jones, Benjimen R. Walker, Michael L. Paffett, Rebekah Bryan, Louis G. Chicoine, Leif D. Nelin, Thomas C. Resta, Edith Tzeng
Publikováno v:
Journal of Applied Physiology. 97:1814-1822
We hypothesized that adenovirus-mediated inducible nitric oxide synthase (iNOS) gene transduction of the lung would result in time-dependent iNOS overexpression and attenuate the vascular constrictor responses to a thromboxane mimetic, U-46619. Rats
Autor:
C. Richard Lyons, Katy Mirowsky, Chunyan Ye, Barbara Masten, Brian Hjelle, Mausumi Bharadwaj, Joyce Yee, Jason Botten
Publikováno v:
Journal of General Virology. 83:1745-1751
We used a deer mouse (Peromyscus maniculatus) infection model to test the protective efficacy of genetic vaccine candidates for Sin Nombre (SN) virus that were known to provoke immunological responses in BALB/c mice (Bharadwaj et al., Vaccine 17, 283
Ig Heavy Chain Complex-Linked Genes Influence the Immune Response in a Murine Cryptococcal Infection
Autor:
Julie A. Lovchik, Julie A. Wilder, Gary B. Huffnagle, Roy Riblet, C. Richard Lyons, Mary F. Lipscomb
Publikováno v:
The Journal of Immunology. 163:3907-3913
A murine pulmonary infection with Cryptococcus neoformans (Cne) has been used to determine mechanisms regulating effective T cell-mediated immunity in the lungs. In BALB/c and C.B-17 mice, following intratracheal deposition of Cne, the fungus initial
Autor:
Roger, Van Andel, Robert, Sherwood, Chris, Gennings, C Richard, Lyons, Julie, Hutt, Andrew, Gigliotti, Ed, Barr
Publikováno v:
Comparative medicine. 58(1)
Since the anthrax attacks of 2001, the emphasis on developing animal models of aerosolized select agent pathogens has increased. Many scientists believe that nonhuman primate models are the most appropriate to evaluate pulmonary response to, vaccines
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 29(3)
Cryptococcus neoformans meningoencephalitis (CNME) is a leading fungal cause of death among acquired immunodeficiency syndrome patients. Innovative preclinical systems that permit high throughput in vivo evaluation of novel agents are desperately nee
Autor:
Conrad Wheeler, Yong-Kang Zhang, Julie A. Lovchik, Kirk R. Maples, Svetlana E. Solovieva, Svetlana S. Printsevskaya, Daniel Chu, Emily Ip, Maria N. Preobrazhenskaya, Henry Heine, Evgenia N. Olsufyeva, Jacob J. Plattner, C. Richard Lyons
Publikováno v:
Journal of medicinal chemistry. 50(15)
Five adamantyl-containing carboxamides of eremomycin or vancomycin were synthesized and their antibacterial activities against some Gram-positive clinical isolates were investigated in vitro and in vivo. The adamantyl-2 amide of glycopeptide antibiot
Publikováno v:
Microbiology (Reading, England). 148(Pt 10)
A polymorphic region was discovered in the genetically uncharacterized opportunistic pathogen Mycobacterium abscessus. The region contains a novel 1.7 kb insertion sequence (IS) named ISMab1. ISMab1 contains two complete ORFs and one partial ORF loca
Autor:
David M. Haaland, Laura E. Martin, C. Richard Lyons, M. Kathleen Alam, Brian Hjelle, Kristen A. Garrison, Jerilyn A. Timlin
Publikováno v:
SPIE Proceedings.
We employ infrared spectroscopy (IR) with attenuated total reflectance (ATR) as a sampling technique to monitor live and dried RAW cells (a murine macrophage cell line) during activation with g-interferon and lipopolysaccharide. By comparing the spec