Výsledky vyhledávání - "C. R. Hutchinson"

Engineered Biosynthesis of Geldanamycin Analogs for Hsp90 Inhibition

Autor: Misty Piagentini, C. R. Hutchinson, Zhihao Hu, Zong-Qiang Tian, Robert Mcdaniel, Kedar G. Patel, Rika Regentin, Greg O. Buchanan, Andreas Rascher

Publikováno v: Chemistry & Biology. 11:1625-1633

SummaryGeldanamycin, a polyketide natural product, is of significant interest for development of new anticancer drugs that target the protein chaperone Hsp90. While the chemically reactive groups of geldanamycin have been exploited to make a number o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef85ad3556303c125a58ceb0d0ae42c
https://doi.org/10.1016/j.chembiol.2004.09.012

Zobrazit plný text záznamu

Alteration of the Substrate Specificity of a Modular Polyketide Synthase Acyltransferase Domain through Site-Specific Mutations

Autor: Gary W. Ashley, Chris Reeves, Misty Piagentini, C R Hutchinson, Sumati Murli, Robert Mcdaniel

Publikováno v: Biochemistry. 40:15464-15470

Cassette replacement of acyltransferase (AT) domains in 6-deoxyerythronolide B synthase (DEBS) with heterologous AT domains with different substrate specificities usually yields the predicted polyketide analogues. As reported here, however, several A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3407d6ef9f59cca77bdcaafad575e3de
https://doi.org/10.1021/bi015864r

Zobrazit plný text záznamu

An acyl-coenzyme A carboxylase encoding gene associated with jadomycin biosynthesis in Streptomyces venezuelae ISP5230 The GenBank accession number for the sequence reported in this paper is AF126429

Autor: Lei Han, Keqian Yang, C. R. Hutchinson, Leo C. Vining, Kerry Kulowski, Evelyn Wendt-Pienkowski

Publikováno v: Microbiology. 146:903-910

Analysis of a region of chromosomal DNA lying between jadR1 and jadI in the gene cluster for jadomycin biosynthesis in Streptomyces venezuelae ISP5230 detected an ORF encoding 584 amino acids similar in sequence to the biotin carboxylase (BC) and bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::411370a86a1d2329a41cd8d63d8aad5a
https://doi.org/10.1099/00221287-146-4-903

Zobrazit plný text záznamu

[Untitled]

Autor: Cheon-Seok Park, C. R. Hutchinson, Jonathan Kennedy, Karine Auclair, John C. Vederas, Steven G. Kendrew

Publikováno v: Antonie van Leeuwenhoek. 78:287-295

Lovastatin biosynthesis in Aspergillus terreus involves two unusual type I multifunctional polyketide syntheses (PKSs). Lovastatin nonaketide synthase (LNKS), the product of the lovB gene, is an iterative PKS that interacts with LovC, a putative enoy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a383275383d2094524c4736e3a356e19
https://doi.org/10.1023/a:1010294330190

Zobrazit plný text záznamu

Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine

Autor: X Liu, Sharee Otten, Krishna M. Madduri, Mark A. Gallo, C. R. Hutchinson

Publikováno v: Journal of Bacteriology. 179:4446-4450

Characterization of the dnmZ, dnmU, and dnmV genes from the daunorubicin-producer Streptomyces peucetius by DNA sequence analysis indicated that these genes encode a protein of unknown function plus a putative thymidine diphospho-4-keto-6-deoxyglucos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daae36b50259effdccfaa7721e7164ea
https://doi.org/10.1128/jb.179.13.4446-4450.1997

Zobrazit plný text záznamu

The DnrN protein of Streptomyces peucetius, a pseudo-response regulator, is a DNA-binding protein involved in the regulation of daunorubicin biosynthesis

Autor: C. R. Hutchinson, Kaoru Furuya

Publikováno v: Journal of Bacteriology. 178:6310-6318

DnrN, a protein essential for the transcription of the dnrI gene, which in turn activates transcription of the daunorubicin biosynthesis genes in Streptomyces peucetius, was overproduced in Escherichia coli and S. peucetius. The cell-free extract fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a32aabea47bcd9dcd99344fa643bf8
https://doi.org/10.1128/jb.178.21.6310-6318.1996

Zobrazit plný text záznamu

Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase

Autor: C. R. Hutchinson, Ben Shen

Publikováno v: Proceedings of the National Academy of Sciences. 93:6600-6604

Aromatic polyketides are assembled by a type 11 (iterative) polyketide synthase (PKS) in bacteria. Understanding the enzymology of such enzymes should provide the information needed for the synthesis of novel polyketides through the genetic engineeri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4585eee3098977c243112e1bfade4d0
https://doi.org/10.1073/pnas.93.13.6600

Zobrazit plný text záznamu

Cloning and characterization of a gene (msdA) encoding methylmalonic acid semialdehyde dehydrogenase from Streptomyces coelicolor

Autor: C. R. Hutchinson, Ying-Xin Zhang, Li Tang

Publikováno v: Journal of Bacteriology. 178:490-495

A homolog of the mmsA gene of Pseudomonas aeruginosa, which encodes methylmalonic acid semialdehyde dehydrogenase (MSDH) and is involved in valine catabolism in pseudomonads and mammals, was cloned and sequenced from Streptomyces coelicolor. Of the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0097c2da2842b475573f6ea71f2e0c
https://doi.org/10.1128/jb.178.2.490-495.1996

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání