Zobrazeno 1 - 10
of 39
pro vyhledávání: '"C. R. Geard"'
Autor:
A. W. Bigelow, G. Randers-Pehrson, G. Garty, C. R. Geard, Y. Xu, A. D. Harken, G. W. Johnson, D. J. Brenner, Floyd D. McDaniel, Barney L. Doyle
Publikováno v:
AIP Conference Proceedings.
The array of microbeam cell-irradiation systems, available to users at the Radiological Research Accelerator Facility (RARAF), Center for Radiological Research, Columbia University, is expanding. The HVE 5MV Singletron particle accelerator at the fac
Publikováno v:
Radiation research. 155(3)
It has long been accepted that radiation-induced genetic effects require that DNA be hit and damaged directly by the radiation. Recently, evidence has accumulated that in cell populations exposed to low doses of alpha particles, biological effects oc
Publikováno v:
Oncology reports. 6(1)
Penclomedine, a synthetic pyridine derivative, has documented antitumor activity and is being investigated in clinical trials. Its mechanism of action is unknown although it may be metabolized to a free radical, DNA-reactive species. We previously re
Autor:
T K, Pandita, E J, Hall, T K, Hei, M A, Piatyszek, W E, Wright, C Q, Piao, R K, Pandita, J C, Willey, C R, Geard, M B, Kastan, J W, Shay
Publikováno v:
Oncogene. 13(7)
Chromosome end-to-end associations seen at metaphase involve telomeres and are commonly observed in cells derived from individuals with ataxia telangiectasia and most types of human tumors. The associations may arise because of short telomeres and/or
Autor:
T K, Pandita, C R, Geard
Publikováno v:
Radiation research. 145(6)
The relative biological effectiveness (RBE) of neutrons for many biological end points varies with neutron energy. To test the hypothesis that the RBE of neutrons varies with respect to their energy for chromosome aberrations in a cell system that do
Publikováno v:
Radiation research. 142(3)
Exposure of synchronized populations of mouse C3H 10T1/2 cells to a single dose (0.6 Gy) of 5.9 MeV neutrons at intervals after mitotic shake-off results in a distinctive variation in the oncogenic transformation frequency through the cell cycle. Pre
Publikováno v:
Radiation research. 142(1)
Primary explants of Syrian hamster embryo (SHE) cells were exposed to either low-LET 250 kVp X rays or graded single doses of defined high-LET alpha particles (90, 100, 120, 150, 180 and 200 keV/microns), simulating those produced by radon progeny, a
Autor:
B D, Loucas, C R, Geard
Publikováno v:
Radiation research. 139(1)
To determine the efficiency at which alpha particles at LETs chosen to simulate exposure to radon progeny break chromosomes, the premature chromosome condensation technique was used to measure breaks soon after irradiation. Noncycling human fibroblas
Autor:
B D, Loucas, C R, Geard
Publikováno v:
Radiation research. 138(3)
To determine whether chromosome breaks produced by alpha particles are processed differently from those produced by X rays, the premature chromosome condensation technique was used to follow chromosome rejoining after irradiation. Doses of 90 and 200
Publikováno v:
Radiation protection dosimetry. 52(1-4)
Synchronised populations of mouse C3H/10T-1/2 cells were obtained by a stringent mitotic dislodgment procedure. Mitotic cells rapidly attach and progress sequentially through the cell cycle. Irradiation (3 Gy of X rays) was carried out at intervals f