Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors

Autor: J. Bouquet, N. Auberger, R. Ashmus, D. King, A. Bordes, N. Fontelle, S. Nakagawa, Z. Madden, C. Proceviat, A. Kato, J. Désiré, D. J. Vocadlo, Y. Blériot

Publikováno v: Organic & Biomolecular Chemistry. 20:619-629

Epimerization/C-alkylation of a seven-membered iminosugar with a broad hexosaminidase inhibition spectrum leads to low micromolar HexAB and NagZ inhibitors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::749d782e2b1e3f791f9e60e67b90d60f
https://doi.org/10.1039/d1ob02280f

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A self-immolative Kdn-glycoside substrate enables high-throughput screening for inhibitors of Kdnases.

Autor: Nejatie A; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada., Proceviat C; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada., Gros C; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada., Steves E; Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada., Moore MM; Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada., Vocadlo DJ; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada., Bennet AJ; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.

Publikováno v: Glycobiology [Glycobiology] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21.