Zobrazeno 1 - 10
of 45
pro vyhledávání: '"C. Posthuma"'
Autor:
Natacha S. Ogando, Francois Ferron, Etienne Decroly, Bruno Canard, Clara C. Posthuma, Eric J. Snijder
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Among RNA viruses, the order Nidovirales stands out for including viruses with the largest RNA genomes currently known. Nidoviruses employ a complex RNA-synthesizing machinery comprising a variety of non-structural proteins (nsps). One of the postula
Externí odkaz:
https://doaj.org/article/9bd97af95df04c988593a4fa6be17fb7
Autor:
Volker Thiel, Jessika C. Zevenhoven-Dobbe, Clara C. Posthuma, Priscila El Kazzi, Eric J. Snijder, Alice Decombe, François Ferron, Natacha S. Ogando, Etienne Decroly, Bruno Canard, Brenda w. Bontes
Publikováno v:
Proceedings of the National Academy of Sciences, 118(49). NATL ACAD SCIENCES
Ogando, Natacha S; El Kazzi, Priscila; Zevenhoven-Dobbe, Jessika C; Bontes, Brenda W; Decombe, Alice; Posthuma, Clara C; Thiel, Volker; Canard, Bruno; Ferron, François; Decroly, Etienne; Snijder, Eric J (2021). Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication. Proceedings of the National Academy of Sciences of the United States of America-PNAS, 118(49) National Academy of Sciences NAS 10.1073/pnas.2108709118
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, ⟨10.1101/2021.05.17.444407⟩
Ogando, Natacha S; El Kazzi, Priscila; Zevenhoven-Dobbe, Jessika C; Bontes, Brenda W; Decombe, Alice; Posthuma, Clara C; Thiel, Volker; Canard, Bruno; Ferron, François; Decroly, Etienne; Snijder, Eric J (2021). Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication. Proceedings of the National Academy of Sciences of the United States of America-PNAS, 118(49) National Academy of Sciences NAS 10.1073/pnas.2108709118
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, ⟨10.1101/2021.05.17.444407⟩
As coronaviruses (CoVs) replicate in the host cell cytoplasm, they rely on their own capping machinery to ensure the efficient translation of their mRNAs, protect them from degradation by cellular 5’ exoribonucleases, and escape innate immune sensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156d64145c316b53403328c37d9acc11
https://hal-amu.archives-ouvertes.fr/hal-03426119/file/2021.05.17.444407.full.pdf
https://hal-amu.archives-ouvertes.fr/hal-03426119/file/2021.05.17.444407.full.pdf
Autor:
Sushil Kumar Tripathi, Jessika C. Zevenhoven-Dobbe, Clara C. Posthuma, Lak Shin Jeong, Natacha S. Ogando, Hyuk Woo Lee, Dnyandev B. Jarhad, Eric J. Snijder
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the lack of treatments to combat infections with human or (potentially) zoonotic CoVs. Thus, it is critical to develop and evaluate antiviral compounds that eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ba5ae0fa739b3e7590d5e4322c0c909
https://doi.org/10.1101/2021.05.20.445077
https://doi.org/10.1101/2021.05.20.445077
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e92970 (2014)
The pandemic influenza A (H1N1) 2009 virus (pH1N1) contains novel gene segments of zoonotic origin that lack virulence and antiviral resistance markers. We aimed to evaluate the applicability and accuracy of mass spectrometry-based comparative sequen
Externí odkaz:
https://doaj.org/article/c8581d32d4544b34ae5b6310667df38b
Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains an N-terminal 3’-to-5’ exoribonuclease (ExoN) and a C-terminal N7-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44d7c3bcff9d8e0ca980a0abc32ae031
https://doi.org/10.1101/2020.06.19.162529
https://doi.org/10.1101/2020.06.19.162529
Autor:
Jessika C. Zevenhoven-Dobbe, Clara C. Posthuma, Peter J. Bredenbeek, Eric J. Snijder, Yvonne van der Meer, Natacha S. Ogando
Publikováno v:
Journal of Virology
Journal of Virology, 94(23). AMER SOC MICROBIOLOGY
Journal of Virology, 94(23). AMER SOC MICROBIOLOGY
The bifunctional nsp14 subunit of the coronavirus replicase contains 3′-to-5′ exoribonuclease (ExoN) and guanine-N7-methyltransferase domains. For the betacoronaviruses MHV and SARS-CoV, ExoN was reported to promote the fidelity of genome replica
Publikováno v:
Virology
Virology, 522, 46-55
Virology, 522, 46-55
Cyclophilins (Cyps) belong to the family of peptidyl-prolyl isomerases (PPIases). The PPIase activity of most Cyps is inhibited by the immunosuppressive drug cyclosporin A and several of its non-immunosuppressive analogs, which can also block the rep
Autor:
Karoly Szuhai, Philippe Gallay, Udayan Chatterji, Eric J. Snijder, Danielle de Jong, Adriaan H. de Wilde, Jessika C. Zevenhoven-Dobbe, Clara C. Posthuma, Corrine Beugeling
Publikováno v:
Virology
Virology, 517, 148-156
Virology, 517, 148-156
Cyclophilin A (CypA) is an important host factor in the replication of a variety of RNA viruses. Also the replication of several nidoviruses was reported to depend on CypA, although possibly not to the same extent. These prior studies are difficult t
Autor:
Clara C. Posthuma, Montserrat Bárcena, A. Linda Boomaars-van der Zanden, Anja W. M. de Jong, Adriaan H. de Wilde, Eric J. Snijder
Publikováno v:
Journal of Virology, 93(18). AMER SOC MICROBIOLOGY
Journal of Virology
Journal of Virology
Previously, the cyclophilin inhibitors cyclosporine (CsA) and alisporivir (ALV) were shown to inhibit the replication of diverse RNA viruses, including arteriviruses and coronaviruses, which both belong to the order Nidovirales. In this study, we aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0e25482bf4c40eda68016b54617fb3
http://hdl.handle.net/1887/121815
http://hdl.handle.net/1887/121815
Autor:
Clara C. Posthuma, Boomaars-van der Zanden Al, de Wilde Ah, Montserrat Bárcena, Eric J. Snijder, de Jong Awm
Previously, the cyclophilin inhibitors cyclosporin A (CsA) and Alisporivir (ALV) were shown to inhibit the replication of diverse RNA viruses, including arteriviruses and coronaviruses, which both belong to the orderNidovirales. Here we aimed to iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fd992f08323eaa8ca968a86c43dce0
https://doi.org/10.1101/587261
https://doi.org/10.1101/587261