Zobrazeno 1 - 10
of 171
pro vyhledávání: '"C. Pilling"'
Autor:
B. Maybee, C. E. Birch, S. J. Böing, T. Willis, L. Speight, A. N. Porson, C. Pilling, K. L. Shelton, M. A. Trigg
Publikováno v:
Natural Hazards and Earth System Sciences, Vol 24, Pp 1415-1436 (2024)
Surface water flooding (SWF) is a severe hazard associated with extreme convective rainfall, whose spatial and temporal sparsity belie the significant impacts it has on populations and infrastructure. Forecasting the intense convective rainfall that
Externí odkaz:
https://doaj.org/article/fa4dfcee193841d5949e28f9d9ed09f6
Autor:
Francesco Casanova, Qu Tian, Daniel S. Williamson, Yong Qian, David Zweibaum, Jun Ding, Janice L. Atkins, David Melzer, Luigi Ferrucci, Luke C. Pilling
Publikováno v:
Neurobiology of Disease, Vol 197, Iss , Pp 106539- (2024)
Background: Iron overload is observed in neurodegenerative diseases, especially Alzheimer's disease (AD) and Parkinson's disease (PD). Homozygotes for the iron-overload (haemochromatosis) causing HFE p.C282Y variant have increased risk of dementia an
Externí odkaz:
https://doaj.org/article/0301ea7a15fa41d9878d92107d865ee1
Publikováno v:
JBMR Plus, Vol 7, Iss 10, Pp n/a-n/a (2023)
ABSTRACT The iron overload disorder hemochromatosis is primarily caused by the homozygous HFE p.C282Y variant, but the scale of excess related musculoskeletal morbidity is uncertain. We estimated hemochromatosis‐genotype associations with clinicall
Externí odkaz:
https://doaj.org/article/9067154c249c4aa3a9075c1607ba0727
Autor:
Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L. Atkins, Joshua R. Lewis, ThuyVy Duong, Shengjun Hong, Mary L. Biggs, Jian’an Luan, Chloe Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M. Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L. Ackert-Bicknell, Dan E. Arking, B. Gwen Windham, Eric Boerwinkle, Megan L. Grove, Misa Graff, Dominik Spira, Ilja Demuth, Nathalie van der Velde, Lisette C. P. G. M. de Groot, Bruce M. Psaty, Michelle C. Odden, Alison E. Fohner, Claudia Langenberg, Nicholas J. Wareham, Stefania Bandinelli, Natasja M. van Schoor, Martijn Huisman, Qihua Tan, Joseph Zmuda, Dan Mellström, Magnus Karlsson, David A. Bennett, Aron S. Buchman, Philip L. De Jager, Andre G. Uitterlinden, Uwe Völker, Thomas Kocher, Alexander Teumer, Leocadio Rodriguéz-Mañas, Francisco J. García, José A. Carnicero, Pamela Herd, Lars Bertram, Claes Ohlsson, Joanne M. Murabito, David Melzer, George A. Kuchel, Luigi Ferrucci, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Luke C. Pilling
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Muscle weakness has been associated with morbidity and mortality in older people. Here, the authors have investigated this trait further by performing a genome-wide meta-analysis of grip strength and Mendelian randomization to discover causal relatio
Externí odkaz:
https://doaj.org/article/c432b68fa4c74f79a795551d0b9372a0
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009783 (2021)
In this paper we review the methodological underpinnings of the general pharmacogenetic approach for uncovering genetically-driven treatment effect heterogeneity. This typically utilises only individuals who are treated and relies on fairly strong ba
Externí odkaz:
https://doaj.org/article/8edadb6867a74942bd7f7485670e41c3
Autor:
Rui Liu, Meiruo Xiang, Luke C. Pilling, David Melzer, Lihong Wang, Kevin J. Manning, David C. Steffens, Jack Bowden, Richard H. Fortinsky, George A. Kuchel, Taeho G. Rhee, Breno S. Diniz, Chia‐Ling Kuo
Publikováno v:
Aging Cell.
Autor:
Chia-Ling Kuo, Rui Liu, Lucas da Cunha Godoy, Luke C. Pilling, Richard H. Fortinsky, Doug Brugge
Publikováno v:
Toxics; Volume 11; Issue 6; Pages: 489
Higher air pollution exposure and shorter leukocyte telomere length (LTL) are both associated with increased risk of coronary heart disease (CHD), and share plausible mechanisms, including inflammation. LTL may serve as a biomarker of air pollution e
Autor:
Deniz Türkmen, Jack Bowden, Jane A.H. Masoli, João Delgado, Chia-Ling Kuo, Luke C. Pilling, David Melzer
BackgroundCalcium channel blockers (CCBs) are common antihypertensive medications. Pharmacogenetic variants affect CCB clinical outcomes, although effect sizes are modest in community samples. Variation in patient characteristics may also predict CCB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4b82b5d6432511c20f62a00d778faca
https://doi.org/10.1101/2023.02.10.23285767
https://doi.org/10.1101/2023.02.10.23285767
Publikováno v:
British Journal of Clinical Pharmacology. 88:3230-3240
To estimate the effect of rs4149056 (SLCO1B1*5) genotype (decreases statin transport) on cholesterol control and treatment duration in male and female primary care patients prescribed common statin medications.This study comprised 69 185 European-anc
BackgroundThe iron overload disorder haemochromatosis is primarily caused by the homozygousHFEp.C282Y variant, but the scale of excess related musculoskeletal morbidity is uncertain.MethodsWe estimated haemochromatosis-genotype associations with clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35d5e9c19a5bc317eccc2d14893f13f6
https://doi.org/10.1101/2022.12.16.22283577
https://doi.org/10.1101/2022.12.16.22283577