Rationale and design of the PRAETORIAN-COVID trial: A double-blind, placebo-controlled randomized clinical trial with valsartan for PRevention of Acute rEspiraTORy dIstress syndrome in hospitAlized patieNts with SARS-COV-2 Infection Disease

Autor: D. H. Frank Gommans, Joris Nas, Sara-Joan Pinto-Sietsma, Yvonne Koop, Regina E. Konst, Frans Mensink, Goaris W.A. Aarts, Lara S.F. Konijnenberg, Kimberley Cortenbach, Dominique V.M. Verhaert, Jos Thannhauser, Jan-Quinten Mol, Maxim J.P. Rooijakkers, Jacqueline L. Vos, Anouke van Rumund, Priya Vart, Robert-Jan Hassing, Jan-Hein Cornel, C. Peter C. de Jager, Michel M. van den Heuvel, Hans G. van der Hoeven, Annelies Verbon, Yigal M. Pinto, Niels van Royen, Roland R.J. van Kimmenade, Peter W. de Leeuw, Michiel A. van Agtmael, Paul Bresser, Wiek H. van Gilst, Anton Vonk-Noordergraaf, Jan G.P. Tijssen

Publikováno v: American Heart Journal
American heart journal, 226, 60-68. Mosby Inc.
American Heart Journal, 226, pp. 60-68
Gommans, D H F, Nas, J, Pinto-Sietsma, S J, Koop, Y, Konst, R E, Mensink, F, Aarts, G W A, Konijnenberg, L S F, Cortenbach, K, Verhaert, D V M, Thannhauser, J, Mol, J Q, Rooijakkers, M J P, Vos, J L, van Rumund, A, Vart, P, Hassing, R J, Cornel, J H, de Jager, C P C, van den Heuvel, M M, van der Hoeven, H G, Verbon, A, Pinto, Y M, van Royen, N, van Kimmenade, R R J, de Leeuw, P W, van Agtmael, M A, Bresser, P, van Gilst, W H, Vonk-Noordergraaf, A, Tijssen, J G P, Event committee, Data Safety Monitoring Board & Steering committee 2020, ' Rationale and design of the PRAETORIAN-COVID trial : A double-blind, placebo-controlled randomized clinical trial with valsartan for PRevention of Acute rEspiraTORy dIstress syndrome in hospitAlized patieNts with SARS-COV-2 Infection Disease: PRAETORIAN-COVID (NCT04335786) ', American Heart Journal, vol. 226, pp. 60-68 . https://doi.org/10.1016/j.ahj.2020.05.010
American Heart Journal, 226, 60-68. MOSBY-ELSEVIER
American Heart Journal, 226, 60-68. Mosby Inc.
American Heart Journal, 226, 60-68

Background There is much debate on the use of angiotensin receptor blockers (ARBs) in severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected patients. Although it has been suggested that ARBs might lead to a higher susceptibility and s

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