Zobrazeno 1 - 10
of 24
pro vyhledávání: '"C. Patrick Case"'
Autor:
Murilo E. Graton, Floor Spaans, Rose He, Paulami Chatterjee, Raven Kirschenman, Anita Quon, Tom J. Phillips, C. Patrick Case, Sandra T. Davidge
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Prenatal hypoxia, a common pregnancy complication, leads to impaired cardiovascular outcomes in the adult offspring. It results in impaired vasodilation in coronary and mesenteric arteries of the adult offspring, due to reduced ni
Externí odkaz:
https://doaj.org/article/ee031b73af094c88bc8fb18478194b8a
Autor:
Paulami Chatterjee, Claudia D. Holody, Raven Kirschenman, Murilo E. Graton, Floor Spaans, Tom J. Phillips, C. Patrick Case, Stephane L. Bourque, Hélène Lemieux, Sandra T. Davidge
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13624 (2023)
Prenatal hypoxia is associated with placental oxidative stress, leading to impaired fetal growth and an increased risk of cardiovascular disease in the adult offspring; however, the mechanisms are unknown. Alterations in mitochondrial function may re
Externí odkaz:
https://doaj.org/article/eda0874f9b0141e0a40327dda3b25da6
Autor:
Tom J. Phillips, Hannah Scott, David A. Menassa, Ashleigh L. Bignell, Aman Sood, Jude S. Morton, Takami Akagi, Koki Azuma, Mark F. Rogers, Catherine E. Gilmore, Gareth J. Inman, Simon Grant, Yealin Chung, Mais M. Aljunaidy, Christy-Lynn Cooke, Bruno R. Steinkraus, Andrew Pocklington, Angela Logan, Gavin P. Collett, Helena Kemp, Peter A. Holmans, Michael P. Murphy, Tudor A. Fulga, Andrew M. Coney, Mitsuru Akashi, Sandra T. Davidge, C. Patrick Case
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental oxidative stress. Here we investigated if gestational hypoxia promotes damaging secreti
Externí odkaz:
https://doaj.org/article/b061c7fc2e2040a6b274efd65f22ba8a
Autor:
Esha Ganguly, Mais M. Aljunaidy, Raven Kirschenman, Floor Spaans, Jude S. Morton, Thomas E. J. Phillips, C. Patrick Case, Christy-Lynn M. Cooke, Sandra T. Davidge
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Pregnancy complications associated with chronic fetal hypoxia have been linked to the development of adult cardiovascular disease in the offspring. Prenatal hypoxia has been shown to increase placental oxidative stress and impair placental function i
Externí odkaz:
https://doaj.org/article/87788c841e1e430ab9314ed7060693a1
Autor:
Sandra T. Davidge, Mais M. Aljunaidy, Floor Spaans, Esha Ganguly, C. Patrick Case, Jude S. Morton, Christy-Lynn M. Cooke, Raven Kirschenman, Thomas E. Phillips
Publikováno v:
Experimental Physiology. 105:1507-1514
New findings What is the central question of this study? Does treatment of hypoxic dams with a placenta-targeted antioxidant prevent the release of placenta-derived factors that impair maturation or growth of fetal cardiomyocytes in vitro? What is th
Autor:
Dionne Tannetta, Michiya Matsusaki, Paul Verkade, Simon Grant, John D. Aplin, Gavin Collett, Jon Hanley, Aman Sood, Fiona Day, Nagaraj D. Halemani, Catherine Murdoch-Davis, Akihiro Nishiguchi, Jennifer McGarvey, Ian L. Sargent, Helena Kemp, Mitsuru Akashi, Catherine E. Gilmore, C. Patrick Case
Publikováno v:
Biomaterials. 192:140-148
Fetal development may be compromised by adverse events at the placental interface between mother and fetus. However, it is still unclear how the communication between mother and fetus occurs through the placenta. In vitro - models of the human placen
Autor:
Floor Spaans, C. Patrick Case, Christy-Lynn M. Cooke, Raven Kirschenman, Esha Ganguly, Claudia D. Holody, Sandra T. Davidge, Michael P. Murphy, Thomas E. Phillips, Hélène Lemieux
Publikováno v:
The FASEB Journal. 35
Pregnancy complications associated with prenatal hypoxia lead to increased placental oxidative stress. Previous studies suggest that prenatal hypoxia can reduce mitochondrial respiratory capacity and mitochondrial fusion, which could lead to placenta
Autor:
Sandra T. Davidge, Raven Kirschenman, Christy-Lynn M. Cooke, Jennie Vu, Thomas J. Phillips, Floor Spaans, Anita Quon, C. Patrick Case, Nataliia Hula
Publikováno v:
Pharmacological research. 165
Offspring born from complicated pregnancies are at greater risk of cardiovascular disease in adulthood. Prenatal hypoxia is a common pregnancy complication that results in placental oxidative stress and impairs fetal development. Adult offspring expo
Autor:
C. Patrick Case, Camille Malouf, Nahid Zareian, Katrin Ottersbach, Allison Blair, Natalie Brown, Christopher Badie, Chrysa Kapeni, Duncan M. Baird, Jon D. Lane, Els Mansell
Publikováno v:
Mansell, E, Zareian, N, Malouf, C, Kapeni, C, Brown, N, Badie, C, Baird, D, Lane, J D, Ottersbach, K, Blair, A & Case, C P 2019, ' DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation ', Scientific Reports, vol. 9, 4370 . https://doi.org/10.1038/s41598-019-39552-0
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Mansell, E, Zareian, N, Malouf, C, Kapeni, C, Brown, N, Badie, C, Baird, D, Lane, J D, Ottersbach, K, Blair, A & Case, C P 2019, ' DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation ', Scientific Reports, vol. 9, no. 1, 4370 . https://doi.org/10.1038/s41598-019-39552-0
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Mansell, E, Zareian, N, Malouf, C, Kapeni, C, Brown, N, Badie, C, Baird, D, Lane, J D, Ottersbach, K, Blair, A & Case, C P 2019, ' DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation ', Scientific Reports, vol. 9, no. 1, 4370 . https://doi.org/10.1038/s41598-019-39552-0
For many diseases with a foetal origin, the cause for the disease initiation remains unknown. Common childhood acute leukaemia is thought to be caused by two hits, the first in utero and the second in childhood in response to infection. The mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bb15d1cb9ed8fbad890b049ab4373a
https://www.pure.ed.ac.uk/ws/files/81560618/s41598_019_39552_0.pdf
https://www.pure.ed.ac.uk/ws/files/81560618/s41598_019_39552_0.pdf
Autor:
Jude S. Morton, Christy-Lynn M. Cooke, Mais M. Aljunaidy, C. Patrick Case, Raven Kirschenman, Sandra T. Davidge, Thomas E. Phillips
Publikováno v:
Pharmacological research. 134
Intrauterine growth restriction, a common consequence of prenatal hypoxia, is a leading cause of fetal morbidity and mortality with a significant impact on population health. Hypoxia may increase placental oxidative stress and lead to an abnormal rel