Výsledky vyhledávání - "C. P. Spears"

Akademický článek

An Unusual Case of Essential Tremor Deep Brain Stimulation: Where is the Lead?

Autor: C. Chauncey Spears, Leonardo Almeida, Michael S. Okun, Wissam Deeb

Publikováno v: Tremor and Other Hyperkinetic Movements, Pp 1-5 (2019)

Clinical Vignette: A 73-year-old female with essential tremor (ET) underwent bilateral thalamic ventralis intermedius (Vim) deep brain stimulation (DBS) surgery. The leads provided tremor benefit, but the location was suboptimal and contributed to st

Externí odkaz: https://doaj.org/article/8a60e68225fc491f9b510e278402a832

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5-(Acylethynyl)uracils, 5-(Acylethynyl)-2'-deoxyuridines and 5-(Acylethynyl)-1-(2-hydroxyethoxy)methyluracils. Their synthesis, antiviral and cytotoxic activities11Part 25 of our series of studies on uracil derivatives and analogues. For part 24, see [1]

Autor: Biswajit Das, Chinmay Chowdhury, Jan Balzarini, C. P. Spears, Erik De Clercq, Jyan S. Mahanty, Nitya G. Kundu, Swapan K. Dasgupta

Publikováno v: European Journal of Medicinal Chemistry. 34:389-398

5-(acylethynyl)uracils 4 were synthesized from 5-iodo-2,4-dimethoxypyrimidine 1 through a palladium-catalyzed reaction with acetylenic carbinols 5, subsequent oxidation with manganese dioxide in dichloromethane, demethylation with 6 N hydrochloric ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc700188c40a02690c93bf28e9ec4138
https://doi.org/10.1016/s0223-5234(99)80088-9

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Palladium-catalysed synthesis of some biologically active 5, 6-disubstituted uracils

Autor: Swapan K. Dasgupta, A.H. Shahinian, C. P. Spears, Palas Das, Nitya G. Kundu

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:2477-2480

Synthesis of some 5-halo-[E]-6(2-p-toluoylvinyl)uracils and some 5-alkynyl-[E]-6-(2-p-toluoylvinyl)uracils through palladium-catalysed procedure and cytotoxicities of the former and [E]-6-(2-p-toluoylvinyl)uracils are reported.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75d26bc0b4bd6eb614d51bc7902ac5b1
https://doi.org/10.1016/0960-894x(96)00451-9

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Clinical Resistance to Antimetabolites

Autor: C. P. Spears

Publikováno v: Hematology/Oncology Clinics of North America. 9:397-414

This article discusses clinically approved and available antimetabolites along with the clinical example of fluorouracil. The thymidylate synthase mechanism of cytotoxicity and results of clinical tumor pharmacodynamics are examined. Some investigati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd8e386fd4335863aa5791a172e1434c
https://doi.org/10.1016/s0889-8588(18)30101-1

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Structure of ethyl phenyl selenone

Autor: H. L. Carrell, H. Hoier, Jenny P. Glusker, C. P. Spears

Publikováno v: Acta Crystallographica Section C Crystal Structure Communications. 49:520-523

C8H10O2Se, M(r) = 217.13, monoclinic, P2(1)/n, a = 9.511 (2), b = 15.741 (3) c = 11.467 (2) A, beta = 91.31 (2) degrees, V = 1716.3 (6) A3, Z = 8 (two molecules per asymmetric unit), Dx = 1.68 Mg m-3, lambda (Mo K alpha) = 0.71069 A, mu = 4.19 mm-1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10208fd0f4bf7039c9576078925fa9bf
https://doi.org/10.1107/s0108270192008230

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Prolonged Continuous Infusion of Fluorouracil With Weekly Bolus Leucovorin: A Phase II Study in Patients With Disseminated Colorectal Cancer

Autor: C. G. Leichman, Susan Groshen, C. P. Spears, Susan Jeffers, Peter J. Rosen, L Leichman

Publikováno v: JNCI Journal of the National Cancer Institute. 85:41-44

Background Biochemical modulation of bolus fluorouracil (5-FU) by addition of leucovorin to the treatment regimen has increased response in patients with disseminated colorectal cancer from fewer than 20% to more than 40%. In view of the short half-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5188250e4e91235bcbc2a730a5e7d74
https://doi.org/10.1093/jnci/85.1.41

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Synthesis and biological activities of [E]-5-(2-acylvinyl)uracils

Autor: Nitya G. Kundu, Jyan S. Mahanty, C. P. Spears, Swapan K. Dasgupta, LN Chaudhuri, A.H. Shahinian

Publikováno v: European Journal of Medicinal Chemistry. 28:473-479

The synthesis of a number of 5-substituted uracils, eg [ E ]-5-(2-acylvinyl)uracils 8a–8g is described. These compounds were found to have cytotoxic activities against CCRF-CEM human lymphoblastoid cells, HT-29 colon carcinoma cells and L1210/0 mou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a07e6115ef41822e4be8f48f29de605
https://doi.org/10.1016/0223-5234(93)90015-7

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