Výsledky vyhledávání - "C. P. Simkevich"

Activation of Ito cells involves regulation of AP-1 binding proteins and induction of type I collagen gene expression

Autor: Rajendra Raghow, Jerome M. Seyer, C. P. Simkevich, Juan Armendáriz-Borunda, Andrew H. Kang, N. Roy

Publikováno v: Biochemical Journal. 304:817-824

Activation of liver Ito cells is characterized by increased proliferation, fibrogenesis, loss of cellular retinoid and change of cell-shape. Here, we have described fundamental differences between freshly isolated Ito cells (FIC) and long-term cultur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026cce5b46a35db7a68543e6b5fe2958
https://doi.org/10.1042/bj3040817

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The transcriptional tissue specificity of the human proα1(I) collagen gene is determined by a negative cis-regulatory element in the promoter

Autor: H Poppleton, Rajendra Raghow, J P Thompson, C P Simkevich

Publikováno v: Biochemical Journal. 286:179-185

The transcriptional activity of plasmid pCOL-KT, in which human pro alpha 1 (I) collagen gene upstream sequences up to -804 and most of the first intron (+474 to +1440) drive expression of the chloramphenicol acetyltransferase (CAT) gene [Thompson, S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8df78dac52d7a291e51657b916ea66
https://doi.org/10.1042/bj2860179

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GABP cooperates with c-Myb and C/EBP to activate the neutrophil elastase promoter

Autor: I, Nuchprayoon, C P, Simkevich, M, Luo, A D, Friedman, A G, Rosmarin

Publikováno v: Blood. 89(12)

Neutrophil elastase (NE) is a serine protease that is transcriptionally regulated during early myeloid differentiation. The murine NE (mNE) promoter contains functionally important c-Myb, C/EBP, and ets binding sites. Deletion of the ets site reduced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3676c63a95843f59dfc2afb6af4470ff
https://pubmed.ncbi.nlm.nih.gov/9192779

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In vitro methylation of the promoter and enhancer of Pro alpha 1(I) collagen gene leads to its transcriptional inactivation

Autor: J P, Thompson, C P, Simkevich, M A, Holness, A H, Kang, R, Raghow

Publikováno v: The Journal of biological chemistry. 266(4)

We created pCOL-KT, a plasmid construct in which the promoter/enhancer of human Pro alpha 1(I) gene is linked to the chloramphenicol acetyl transferase reporter gene. The Pro alpha 1(I) promoter/enhancer in pCOL-KT was methylated in vitro and tested

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e4be9f1a0d6270c2118eaa0fabd550b5
https://pubmed.ncbi.nlm.nih.gov/1990005

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