Impact of the Reticular Stress and Unfolded Protein Response on the inflammatory response in endometrial stromal cells

Autor: Rosiane Mattar, Thalita Frutuoso Lobo, S. Gori, Lucila Gallino, Gustavo Martínez, Elizabeth Soczewski, Daiana Vota, Marcela Irigoyen, C. Ruhlmann, G. Salamone, E. Grasso, Silvia Daher, C. Pérez Leirós, Rosanna Ramhorst, Laura Fernández

Publikováno v: Scientific Reports
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

During decidualization, endometrial stromal cells undergo reticular stress (RS) and unfolded protein response (UPR), allowing the endoplasmic reticulum-expansion and immunomodulators production. Physiological RS generates the activation of sensing pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd84e23e594aa93d7fb5cc5b3a6cfcf
https://www.nature.com/articles/s41598-018-29779-8

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Acetylcholine contributes to control the physiological inflammatory response during the peri-implantation period

Autor: Soledad Gori, Daniel Paparini, W. Scordo, E. Grasso, Gabriela Salamone, C. Pérez Leirós, Rosanna Ramhorst, Guillermina Calo

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Maternal antigen-presenting cells attracted to the pregnant uterus interact with trophoblast cells and modulate their functional profile to favour immunosuppressant responses. Non-neuronal cholinergic system is expressed in human cytotrophoblast cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e78b27605ba10ffd90d3c87ddcdff1d
https://doi.org/10.1111/apha.12494

Defects in the vasoactive intestinal peptide (VIP)/VPAC system during early stages of the placental–maternal leucocyte interaction impair the maternal tolerogenic response

Autor: Vanesa Hauk, C. Pérez Leirós, Guillermina Calo, Esteban Grasso, Rosanna Ramhorst, M. Cortelezzi, Laura Fraccaroli

Publikováno v: Clinical and Experimental Immunology. 170:310-320

Summary Successful embryo implantation occurs followed by a local inflammatory/T helper type 1 (Th1) response, subsequently redirected towards a tolerogenic predominant profile. The lack of control of this initial local inflammatory response may be a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56eaf19363d90a69c6606d568d7940c
https://doi.org/10.1111/j.1365-2249.2012.04668.x

VIP and Tolerance Induction in Autoimmunity

Autor: Javier Leceta, Florencia Rosignoli, Yasmina Juarranz, M. Torroba, Carmen Martínez, Maria Garcia-Gomez, Rosa P. Gomariz, C. Pérez-Leirós

Publikováno v: Annals of the New York Academy of Sciences. 1070:525-530

Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with VIP in the development of diab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8e7136fb1634bb808724a5f8055cd1
https://doi.org/10.1196/annals.1317.073