Zobrazeno 1 - 10
of 372
pro vyhledávání: '"C. Ostrowski"'
Autor:
Benjamin R. Pryce, Alexander Oles, Erin E. Talbert, Martin J. Romeo, Silvia Vaena, Sudarshana Sharma, Victoria Spadafora, Lauren Tolliver, David A. Mahvi, Katherine A. Morgan, William P. Lancaster, Eryn Beal, Natlie Koren, Bailey Watts, Morgan Overstreet, Stefano Berto, Suganya Subramanian, Kubra Calisir, Anna Crawford, Brian Neelon, Michael C. Ostrowski, Teresa A. Zimmers, James G. Tidball, David J. Wang, Denis C. Guttridge
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114925- (2024)
Summary: Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with local tissue inflammation. We queried the regulation of this inflammation and its ca
Externí odkaz:
https://doaj.org/article/d485e34a70874913a4928068b00e19df
Autor:
Victoria Spadafora, Benjamin R. Pryce, Alexander Oles, Erin E. Talbert, Martin Romeo, Silvia Vaena, Stefano Berto, Michael C. Ostrowski, David J. Wang, Denis C. Guttridge
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-19 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is metastasis which occurs in ~ 80% of PDAC patients. The second is cachexia, w
Externí odkaz:
https://doaj.org/article/c0dab385199c4f3b81dbc7e59c365feb
Autor:
Bradley A. Krisanits, Reid Schuster, Jaime Randise, Lourdes M. Nogueira, Jackson T. Lane, Gowtami A. Panguluri, Hong Li, Kristi Helke, Maria C. Cuitiño, Christopher Koivisto, Laura Spruill, Michael C. Ostrowski, Steven M. Anderson, David P. Turner, Victoria J. Findlay
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-17 (2023)
Abstract Background Advanced glycation end products (AGEs) are reactive metabolites intrinsically linked with modern dietary patterns. Processed foods, and those high in sugar, protein and fat, often contain high levels of AGEs. Increased AGE levels
Externí odkaz:
https://doaj.org/article/0337fd19f5054494afdb0a79e61992ea
Autor:
Tyler P. Robinson, Tewfik Hamidi, Brittany Counts, Denis C. Guttridge, Michael C. Ostrowski, Teresa A. Zimmers, Leonidas G. Koniaris
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The development of cachexia in the setting of cancer or other chronic diseases is a significant detriment for patients. Cachexia is associated with a decreased ability to tolerate therapies, reduction in ambulation, reduced quality of life, and incre
Externí odkaz:
https://doaj.org/article/332033ea659f4e458bf79196e42a53de
Autor:
Lu Han, Yongxia Wu, Kun Fang, Sean Sweeney, Ulyss K. Roesner, Melodie Parrish, Khushbu Patel, Tom Walter, Julia Piermattei, Anthony Trimboli, Julia Lefler, Cynthia D. Timmers, Xue-Zhong Yu, Victor X. Jin, Michael T. Zimmermann, Angela J. Mathison, Raul Urrutia, Michael C. Ostrowski, Gustavo Leone
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Cancer-associated fibroblasts (CAFs) are the main component of the stroma in pancreatic cancer, but their tissue of origin remains to be defined. Here the authors perform lineage tracing and single cell RNA sequencing in mice and suggest the splanchn
Externí odkaz:
https://doaj.org/article/f4eb874301cd413b8b8363efaf0dfe69
Autor:
Katie A. Thies, Matthew W. Cole, Rachel E. Schafer, Jonathan M. Spehar, Dillon S. Richardson, Sarah A. Steck, Manjusri Das, Arthur W. Lian, Alo Ray, Reena Shakya, Sue E. Knoblaugh, Cynthia D. Timmers, Michael C. Ostrowski, Arnab Chakravarti, Gina M. Sizemore, Steven T. Sizemore
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-17 (2021)
Abstract Background Breast cancer (BC) is the most common cancer in women and the leading cause of cancer-associated mortality in women. In particular, triple-negative BC (TNBC) has the highest rate of mortality due in large part to the lack of targe
Externí odkaz:
https://doaj.org/article/986a2f2be5dc406fa9d8fb78e612f5b5
Autor:
Shasha Yin, Liu Liu, Charles Brobbey, Viswanathan Palanisamy, Lauren E. Ball, Shaun K. Olsen, Michael C. Ostrowski, Wenjian Gan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Arginine methylation has been reported to regulate AKT-associated signalling. Here, the authors show that PRMT5-mediated arginine methylation promotes AKT activity and induces tumourigenesis.
Externí odkaz:
https://doaj.org/article/631d7841dc4149218d5fce9d5cee9748
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
The signaling mechanisms by which dietary fat and cholesterol signals regulate central pathways of glucose homeostasis are not completely understood. By using a hepatocyte-specific PKCβ-deficient (PKCβHep–/–) mouse model, we demonstrated the ro
Externí odkaz:
https://doaj.org/article/c4a0b39f28f34af4a669bb5d8f6e8633
Autor:
Heather A. Carey, Blake E. Hildreth, III, Devadoss J. Samuvel, Katie A. Thies, Thomas J. Rosol, Ramiro E. Toribio, Julia F. Charles, Michael C. Ostrowski, Sudarshana M. Sharma
Publikováno v:
iScience, Vol 11, Iss , Pp 238-245 (2019)
Summary: Bone-resorbing osteoclasts (OCs) are derived from myeloid precursors (MPs). Several transcription factors are implicated in OC differentiation and function; however, their hierarchical architecture and interplay are not well known. Analysis
Externí odkaz:
https://doaj.org/article/4be868fa1ecd4874b54ecea31d64c241
Autor:
Caitlin E. Jones, Anisha M. Hammer, YouJin Cho, Gina M. Sizemore, Edna Cukierman, Lisa D. Yee, Samir N. Ghadiali, Michael C. Ostrowski, Jennifer L. Leight
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 1, Pp 132-145 (2019)
The organization of the extracellular matrix has a profound impact on cancer development and progression. The matrix becomes aligned throughout tumor progression, providing “highways” for tumor cell invasion. Aligned matrix is associated with bre
Externí odkaz:
https://doaj.org/article/fb890cfa8be04e6385066d38ace09c7d