Zobrazeno 1 - 10 of 39 pro vyhledávání: '"C. O. Savage"'
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ANCA-associated vasculitis is linked to carriage of the Z allele of α₁ antitrypsin and its polymers
Autor: H, Morris, M D, Morgan, A M, Wood, S W, Smith, U I, Ekeowa, K, Herrmann, J U, Holle, L, Guillevin, D A, Lomas, J, Perez, C D, Pusey, A D, Salama, R, Stockley, S, Wieczorek, A J, McKnight, A P, Maxwell, E, Miranda, J, Williams, C O, Savage, L, Harper
Publikováno v: Annals of the rheumatic diseases. 70(10)
Small studies have linked α1 antitrypsin (α1AT) deficiency to patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV).To test the validity and the mechanism of this association between α1AT and AAV.The distribution o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ccade4d73df626d9b47b870a1fcfc440
https://pubmed.ncbi.nlm.nih.gov/21821620
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4
Antineutrophil cytoplasmic antibodies stabilize adhesion and promote migration of flowing neutrophils on endothelial cells
Autor: D J, Radford, N T, Luu, P, Hewins, G B, Nash, C O, Savage
Publikováno v: Arthritis and rheumatism. 44(12)
Recruitment of neutrophils to sites of inflammation requires coordinated regulation of their capture, activation, and migration on vascular endothelium. This study examines whether exposure of neutrophils to antineutrophil cytoplasmic antibodies (ANC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbea36f85b57ea04641725a39f155473
https://pubmed.ncbi.nlm.nih.gov/11762946
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5
IgG from myeloperoxidase-antineutrophil cytoplasmic antibody-positive patients stimulates greater activation of primed neutrophils than IgG from proteinase 3-antineutrophil cytosplasmic antibody-positive patients
Autor: L, Harper, D, Radford, T, Plant, M, Drayson, D, Adu, C O, Savage
Publikováno v: Arthritis and rheumatism. 44(4)
Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) have been reported to be pathologically and clinically different. The aim of this study was to assess whether these differences could be explained by differing abilities of proteinase 3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b9fc249943da27bcd110eadc5f2ad9a
https://pubmed.ncbi.nlm.nih.gov/11315931
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6
Treatment of vasculitic IgA nephropathy
Autor: L, Harper, M A, Ferreira, A J, Howie, C O, Savage, N T, Richards, J, Michael, D, Adu
Publikováno v: Journal of nephrology. 13(5)
Patients with IgA nephropathy and histological vasculitic/crescentic lesions have a poor prognosis. We performed a retrospective study to assess whether treatment with steroids and immunosuppressants would preserve renal function by healing these les
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38a6b5ef558f700c1eb5b6c327438efa
https://pubmed.ncbi.nlm.nih.gov/11063140
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7
Treatment of rolling neutrophils with antineutrophil cytoplasmic antibodies causes conversion to firm integrin-mediated adhesion
Autor: D J, Radford, C O, Savage, G B, Nash
Publikováno v: Arthritis and rheumatism. 43(6)
The vascular lesions associated with autoimmune small-vessel vasculitis may arise from activation of circulating neutrophils by antineutrophil cytoplasmic antibodies (ANCA), resulting in increased adhesion of these neutrophils to the vessel wall. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::099cdebe3dbe9f5b642a66c42adbf998
https://pubmed.ncbi.nlm.nih.gov/10857792
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8
Pathogenesis of ANCA-associated systemic vasculitis
Autor: L, Harper, C O, Savage
Publikováno v: The Journal of pathology. 190(3)
The aetiology of primary systemic vasculitides remains unknown. Recent advances have been made in the understanding of relevant mechanisms of inflammation, particularly the role of the endothelium and interactions with inflammatory mediators and immu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbcb3c0432a3a5dbc686be4b93df7898
https://pubmed.ncbi.nlm.nih.gov/10685069
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9
Mechanisms of endothelial injury in systemic vasculitis
Autor: L, Harper, C O, Savage
Publikováno v: Advances in nephrology from the Necker Hospital. 29
The precise etiology of primary systemic vasculitis remains unknown. However, recent advances in the understanding of the role of and interaction between the vascular endothelium, mediators, and immune effector cells have helped to further elucidate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5bfa9cfd7a1e297c0627fcb531279ea7
https://pubmed.ncbi.nlm.nih.gov/10561734
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10
IgG anti-endothelial cell autoantibodies from patients with systemic lupus erythematosus or systemic vasculitis stimulate the release of two endothelial cell-derived mediators, which enhance adhesion molecule expression and leukocyte adhesion in an autocrine manner
Autor: D, Carvalho, C O, Savage, D, Isenberg, J D, Pearson
Publikováno v: Arthritis and rheumatism. 42(4)
To investigate the ability of anti-endothelial cell antibodies (AECA) to modulate endothelial cell function.The effects of purified IgG from 11 patients with systemic lupus erythematosus (SLE) and 4 patients with systemic vasculitis on the expression
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9dfcd6ba94bcb5159c072e2e16c997d5
https://pubmed.ncbi.nlm.nih.gov/10211876
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