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pro vyhledávání: '"C. Nishihara"'
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Autor:
Feny Gunawan, Julie C. Nishihara, Donald E. Walker, X. Christopher Yu, Eric Huang, Martin Vanderlaan, Denise C. Krawitz, Judith Zhu-Shimoni, Inn H. Yuk, Pynn Abigail Friederike Joyce, Jayashree Subramanian
Publikováno v:
Biotechnology and Bioengineering. 112:2068-2083
To understand the diversity in the cell culture harvest (i.e., feedstock) provided for downstream processing, we compared host cell protein (HCP) profiles using three Chinese Hamster Ovary (CHO) cell lines in null runs which did not generate any reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91a82618b1a5ff3aeacb15cc59cd307b
https://doi.org/10.1002/bit.25615
https://doi.org/10.1002/bit.25615
Autor:
Wendy Sandoval, Julie C. Nishihara, Denise Krawitz, Heidi Zhang, Marty Vanderlaan, Peter Liu, Feny Gunawan
Publikováno v:
Biotechnology and bioengineering. 115(2)
During expression of biotherapeutic proteins, complex mixtures of additional proteins are also produced by normal expression machinery of the host cell (termed "host cell proteins," or HCP). HCPs pose a potential impact to patient safety and product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8c6e514645f3f9d1d6a2ab014c6ed0
https://pubmed.ncbi.nlm.nih.gov/28986978
https://pubmed.ncbi.nlm.nih.gov/28986978
Autor:
Camellia Zamiri, Nicholas Woon, Ming Lei, Taylor Yonghua Zhang, Yung-Hsiang Kao, Toshiro Carcelen, Cynthia P. Quan, Julie C. Nishihara, Christian Schöneich, Yuzhe Hu, Benjamin T. Walters, Holly Yip
Publikováno v:
Analytical chemistry. 89(13)
Light is known to induce covalently linked aggregates in proteins. These aggregates can be immunogenic and are of concern for drug product development in the biotechnology industry. Histidine (His) is proposed to be a key residue in cross-link genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61b5b9347eeecaf2181ba7d620deaf8
https://pubmed.ncbi.nlm.nih.gov/28585810
https://pubmed.ncbi.nlm.nih.gov/28585810
Autor:
Robert M. Wong, Julie C. Nishihara, Christopher Yu, Peter Liu, Judith Zhu-Shimoni, Feny Gunawan, Martin Vanderlaan, Wendy Sandoval, Margaret S. Lin, Denise C. Krawitz
Publikováno v:
Biotechnology and Bioengineering. 111:2367-2379
Host cell proteins (HCPs) are among the process-related impurities monitored during recombinant protein pharmaceutical process development. The challenges of HCP detection include (1) low levels of residual HCPs present in large excess of product pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a05a416ca5a5fa3f9a75423227c0058
https://doi.org/10.1002/bit.25327
https://doi.org/10.1002/bit.25327
Autor:
Kenji C Nishihara, Klaus Albertshofer, Brett P. Monia, Eric E. Swayze, Martin Maier, Leila Malik, Andrew M. Siwkowski, C. Frank Bennett, Anne B. Eldrup, Edward Wancewicz, Garth A. Kinberger, Richard S. Geary, Christine Esau, Richard H. Griffey, Muthiah Manoharan, Tanya Watanabe
Publikováno v:
Journal of Medicinal Chemistry. 48:6741-6749
Improving cellular uptake and biodistribution remains one of the major obstacles for a successful and broad application of peptide nucleic acids (PNAs) as antisense therapeutics. Recently, we reported the identification and functional characterizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99435f07c1247e482294ae1976ff9413
https://doi.org/10.1021/jm050490b
https://doi.org/10.1021/jm050490b
Autor:
Christina Y. Chen, Denise C. Krawitz, William F. Forrest, Kathleen M. Champion, Ilana S. Aldor, Julie C. Nishihara, John C. Joly
Publikováno v:
Applied and Environmental Microbiology. 71:1717-1728
By using two-dimensional polyacrylamide gel electrophoresis, a proteomic analysis over time was conducted with high-cell-density, industrial, phosphate-limited Escherichia coli fermentations at the 10-liter scale. During production, a recombinant, hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643a6b9c6704b9b1a164fe28b9b1f689
https://doi.org/10.1128/aem.71.4.1717-1728.2005
https://doi.org/10.1128/aem.71.4.1717-1728.2005
Autor:
Kay D. Beharry, Tamerou Asrat, Kenji C. Nishihara, Joshua Waltzman, Eileen Chang, David Gorenberg, Aamir Akmal
Publikováno v:
American Journal of Obstetrics and Gynecology. 192:924-931
Objective The purpose of this study was to examine whether the pregnant rabbit model can be used as a viable model for the study of non–infection-mediated preterm birth. Study design Timed pregnant New Zealand rabbits were injected with a single do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4bba9f76c666d57b41780a559b331b
https://doi.org/10.1016/j.ajog.2004.11.061
https://doi.org/10.1016/j.ajog.2004.11.061
Autor:
Nicole Hausman, Kay D. Beharry, Kenji C. Nishihara, Yasir Akmal, Tamerou Asrat, Yuri Stavitsky
Publikováno v:
American Journal of Obstetrics and Gynecology. 189:1744-1750
Objective The purpose of this study was to test the hypothesis that the maternal administration of therapeutic doses of celecoxib would not affect ductus arteriosus patency or alter renal and hepatic prostanoids in the fetal rabbit. Study design Preg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540de72020d3b88eed594fbcd218db04
https://doi.org/10.1016/s0002-9378(03)00831-7
https://doi.org/10.1016/s0002-9378(03)00831-7
Autor:
Dana C. Andersen, Martin Vanderlaan, G. Tony Moreno, Julie C. Nishihara, Kathleen M. Champion, Kathy L. Stults, Ilana S. Aldor
Publikováno v:
PROTEOMICS. 3:1365-1373
Two-dimensional electrophoretic analyses of Escherichia coli cells producing recombinant human growth hormone (Nutropin) in fermentations were conducted. The resulting two-dimensional protein profiles were compared with those of nonproducing (blank)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832950db0239412d0602050d74eee1ab
https://doi.org/10.1002/pmic.200300430
https://doi.org/10.1002/pmic.200300430