Zobrazeno 1 - 10
of 22
pro vyhledávání: '"C. Nicholas Hodge"'
Autor:
Nikolai F. Sepetov, James D. Arroway, Olga Issakova, Dennis Lagasca, Ajit Jadhav, Min Chen, Ioana Popa-Burke, Paul Bernasconi, Scott Galasinski, Robert P. Mohney, Darren A. Sparkman, Roderic S. Lewis, Louis Coudurier, Darren Liu, William P. Janzen, C. Nicholas Hodge
Publikováno v:
Analytical Chemistry. 76:7278-7287
As part of an overall systems approach to generating highly accurate screening data across large numbers of compounds and biological targets, we have developed and implemented streamlined methods for purifying and quantitating compounds at various st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5b3d284d231f4c3b9f70568276a136
https://doi.org/10.1021/ac0491859
https://doi.org/10.1021/ac0491859
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3615-3620
A new class of tricyclic ureas containing a conformationally constrained proline was designed with the aid of molecular modeling. Efficient stereoselective intermolecular pinacol coupling represented the highlight of the synthesis. These rigid cyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2343903b97a7d8208596e436a6f28f19
https://doi.org/10.1016/s0960-894x(98)00659-3
https://doi.org/10.1016/s0960-894x(98)00659-3
Publikováno v:
Tetrahedron Letters. 38:7951-7954
Trans-3-alkyl- or -arylcyclopropanecarboxylates, substituted in the 2-position with alkoxycarbonyl or nitrile groups, are efficiently prepared by coupling bromoacetic acid with Wang resin followed by pyridinium ylide formation and condensation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95fb04a5ac47dbef2dd3f4150cce1805
https://doi.org/10.1016/s0040-4039(97)10081-8
https://doi.org/10.1016/s0040-4039(97)10081-8
Autor:
C. Nicholas Hodge, Zelda R. Wasserman
Publikováno v:
Proteins: Structure, Function, and Genetics. 24:227-237
We used molecular dynamics computer simulation to "fly" a small flexible ligand, L-leucine hydroxamic acid, into the active site of thermolysin. The potential, which imposed no constraints between protein and ligand, produced conformations close to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b69790ff57c387a8c1bee1fdce84dc8
https://doi.org/10.1002/(sici)1097-0134(199602)24:2<227::aid-prot9>3.0.co
https://doi.org/10.1002/(sici)1097-0134(199602)24:2<227::aid-prot9>3.0.co
Publikováno v:
The Journal of Organic Chemistry. 61:2081-2084
A new procedure for cyclohexenone annelation has been developed. Thus, alkylation of 4-isopropylcyclohexanone with allyl bromide gives, over several steps, ketone 8. Exposure to (trimethylsilyl)diazomethane and MeLi smoothly cyclized 8 to the cyclope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae2dd31ec95cbe2cf774b4fc74dc0ddb
https://doi.org/10.1021/jo951949k
https://doi.org/10.1021/jo951949k
Autor:
Brock A. Luty, J. Andrew McCammon, C. Nicholas Hodge, Zelda R. Wasserman, Martin Zacharias, Pieter F. W. Stouten
Publikováno v:
Journal of Computational Chemistry. 16:454-464
We present a computational method for prediction of the conformation of a ligand when bound to a macromolecular receptor. The method is intended for use in systems in which the approximate location of the binding site is known and no large-scale rear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdcba29e364acdd054955be83127886b
https://doi.org/10.1002/jcc.540160409
https://doi.org/10.1002/jcc.540160409
Autor:
Patrick Y. S. Lam, Prabhakar K. Jadhav, Charles J. Eyermann, C. Nicholas Hodge, Yu Ru, Lee T. Bacheler, James L. Meek, Michael J. Otto, Marlene M. Rayner, Y. Nancy Wong, Chong-Hwan Chang, Patricia C. Weber, David A. Jackson, Thomas R. Sharpe, Susan Erickson-Viitanen
Publikováno v:
Science. 263:380-384
Mechanistic information and structure-based design methods have been used to design a series of nonpeptide cyclic ureas that are potent inhibitors of human immunodeficiency virus (HIV) protease and HIV replication. A fundamental feature of these inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf0c05431eed61ed04c9d891dc5d777
https://doi.org/10.1126/science.8278812
https://doi.org/10.1126/science.8278812
Publikováno v:
ChemInform. 30
A new class of tricyclic ureas containing a conformationally constrained proline was designed with the aid of molecular modeling. Efficient stereoselective intermolecular pinacol coupling represented the highlight of the synthesis. These rigid cyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1702ce14f5f452f9d1ac49cf057a9684
https://doi.org/10.1002/chin.199917166
https://doi.org/10.1002/chin.199917166
Publikováno v:
Electrophoresis. 29(6)
For microfluidic analytical instruments, a facile, fast, and accurate instrument test is highly demanded. The test includes the quantitative verification of the relationship between pressure drop and flow velocity for the hydrodynamic pump, between t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb137d6acc6d6981a60f639f776b318
https://pubmed.ncbi.nlm.nih.gov/18297657
https://pubmed.ncbi.nlm.nih.gov/18297657
Publikováno v:
Journal of biomolecular screening. 8(6)
It is generally accepted that the conversion of substrate should be kept at less than 10% of the total substrate used when studying enzyme kinetics. However, 10% or less substrate conversion often will not produce sufficient signal changes required f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4323d50b3de95ad2514eec6e5c713672
https://pubmed.ncbi.nlm.nih.gov/14711395
https://pubmed.ncbi.nlm.nih.gov/14711395