Zobrazeno 1 - 10
of 56
pro vyhledávání: '"C. Nicholas Hales"'
Publikováno v:
Scopus-Elsevier
International journal of experimental diabetes research
International journal of experimental diabetes research
Restricted fetal growth is associated with increased risk for the future development of Type 2 diabetes in humans. The study aim was to assess the glucose tolerance of old (seventeen months) male rats, which were growth restricted in early life due t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c411cfe8303eedb26520f1bb844d4291
Publikováno v:
FEBS Letters. 579:6388-6394
Replicatively and oxidatively senescent human fibroblasts demonstrate an impaired response to mitogens. To investigate whether this is due to downregulation of growth factor receptors we examined their expression in these two types of senescence. mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c73bce0ea5c42dc3ef0daceb8f4840f
https://doi.org/10.1016/j.febslet.2005.09.102
https://doi.org/10.1016/j.febslet.2005.09.102
Publikováno v:
Clinical Science. 106:141-145
Poor early growth is associated with Type II diabetes, hypertension and other features of the metabolic syndrome in adulthood. It has been suggested that this results from the development of a thrifty phenotype by a malnourished fetus. Such a phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e536d5e331888c55118e660f7ddc21b
https://doi.org/10.1042/cs20030278
https://doi.org/10.1042/cs20030278
Publikováno v:
Circulation. 105:2153-2158
Background — Some, but not all, studies have reported a relationship between plasma insulin and coronary heart disease (CHD). Conventional nonspecific insulin assays are also measuring various fractions of proinsulin-like molecules due to cross-rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d42b2170c49a0aba65814d7aa1a65119
https://doi.org/10.1161/01.cir.0000015855.04844.e7
https://doi.org/10.1161/01.cir.0000015855.04844.e7
Autor:
Lars Lind, Hans Lithell, Bengt Vessby, C. Nicholas Hales, Johan Ärnlöv, Björn Zethelius, Bertil Andrén
Publikováno v:
American Heart Journal. 142:720-724
The epidemiologic data on heart failure are scarce. This study aimed at identifying predictors of left ventricular systolic dysfunction in a cohort of middle-aged men with a 20-year follow-up.A population-based cohort of 431 50-year-old men was exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20735a1b8fe77225bf1d62cca5ca2352
https://doi.org/10.1067/mhj.2001.116957
https://doi.org/10.1067/mhj.2001.116957
Autor:
Nicholas E. Day, Nicholas J. Wareham, Christopher D. Byrne, C. Nicholas Hales, Patrick Maison
Publikováno v:
Diabetes Care. 24:1758-1763
OBJECTIVE—The metabolic syndrome is a loosely defined cluster of cardiovascular risk factors including low HDL cholesterol, hypertriglyceridemia, glucose intolerance, and hypertension. Evidence for inclusion of these features in the syndrome has mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d9dc36accb3826fb31467d20e8e4e97
https://doi.org/10.2337/diacare.24.10.1758
https://doi.org/10.2337/diacare.24.10.1758
Autor:
C. Nicholas Hales, C. L. Wang, Constantinos L. Loizou, Susan E. Ozanne, Clive J. Petry, Nick D. Martensz
Publikováno v:
Metabolism. 50:1070-1077
An animal model of protein restriction during pregnancy and lactation with subsequent dietary fatty acid manipulation was used to investigate the association between poor early growth, defective unsaturated fatty acid handling, and later disease. Bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bf05c2b5836df4b045556219a80576
https://doi.org/10.1053/meta.2001.25602
https://doi.org/10.1053/meta.2001.25602
Autor:
Clive J. Petry, C. Nicholas Hales
Publikováno v:
Human Reproduction Update. 6:578-586
The number of cell divisions during embryonic and fetal life makes the embryo/fetus particularly vulnerable to effects resulting from exposure to an adverse intrauterine environment. Exposure to drugs and irradiation at this stage of development are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0f7fa130fd59f6d453008501f5a1b6
https://doi.org/10.1093/humupd/6.6.578
https://doi.org/10.1093/humupd/6.6.578
Publikováno v:
Molecular Genetics and Metabolism. 71:32-42
There is substantial and long-standing literature linking the level of general nutrition to longevity. Reducing nutrition below the amount needed to sustain maximum growth increases longevity in a wide range of organisms. Oxidative damage has been sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2b1e96dccc1ec3031f3755a82a3ea0
https://doi.org/10.1006/mgme.2000.3077
https://doi.org/10.1006/mgme.2000.3077
Publikováno v:
Metabolism. 49:81-87
In previous studies, a cross-sectional association has been described between blood pressure (BP) and nonesterified fatty acid (NEFA) concentrations. The direction of causality, and thus, the mechanism explaining this relationship, remains uncertain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc918a32689c45120bb1076db73854dd
https://doi.org/10.1016/s0026-0495(00)90788-1
https://doi.org/10.1016/s0026-0495(00)90788-1