Zobrazeno 1 - 5
of 5
pro vyhledávání: '"C. N. Naveen Kumar"'
Autor:
V. K. Ramya, Vijender Panduga, Gajanan Shanbhag, Michelle Coulson, Sowmya Bharath, Vaishali Humnabadkar, Prashanti Madhavapeddi, Vasan K. Sambandamurthy, Disha Awasthy, Jim Werngren, Praveena Manjrekar, Chandan Narayan, Vijayashree Achar, Mahesh Kumar Kn, Sunita M. de Sousa, Jitendar Reddy, C. N. Naveen Kumar, Kakoli Mukherjee, Sreenivasaiah Menasinakai, Ugarkar Bheemarao, Samit Ganguly, Umender Sharma, David Waterson, Vikas Patil, Sven Hoffner, Radha Nandishaiah, Sreevalli Sharma, Shahul Hameed P, Uma Arora, Anandkumar Raichurkar, Suresh Solapure, Parvinder Kaur, Jayashree Puttur, Vikas Shinde, Murugan Chinnapattu, Suresh Rudrapatana, Sheshagiri Gaonkar, Anirban Ghosh
Publikováno v:
Journal of Medicinal Chemistry. 57:4889-4905
DNA gyrase is a clinically validated target for developing drugs against Mycobacterium tuberculosis (Mtb). Despite the promise of fluoroquinolones (FQs) as anti-tuberculosis drugs, the prevalence of pre-existing resistance to FQs is likely to restric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8505fa2cf6ba2e099b397f5538c9f37f
https://doi.org/10.1021/jm500432n
https://doi.org/10.1021/jm500432n
Autor:
P. Ann Boriack-Sjodin, B. K. Kishore Reddy, Ramesh R. Kale, Vijaykamal Ahuja, Sunita M. de Sousa, Krishnan Malolanarasimhan, Sheshagiri Gaonkar, Anandkumar Raichurkar, Sreenivasaiah Menasinakai, Halesha D. Basavarajappa, Prashanti Madhavapeddi, M. R. Manjunatha, Shahul Hameed, David Waterson, Radha Nandishaiah, Vasan K. Sambandamurthy, C. N. Naveen Kumar, Derek Ogg, Vikas Shinde, Vaishali Humnabadkar, Krishna Koushik, Sreevalli Sharma, K. N. Mahesh Kumar, Sandeep R. Ghorpade, Kale Manoj Ganpat, Samit Ganguly, Lalit kumar Jena
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:870-879
Scaffold hopping from the thiazolopyridine ureas led to thiazolopyridone ureas with potent antitubercular activity acting through inhibition of DNA GyrB ATPase activity. Structural diversity was introduced, by extension of substituents from the thiaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f597532256fbaf9317ffdec02a7322
https://doi.org/10.1016/j.bmcl.2013.12.080
https://doi.org/10.1016/j.bmcl.2013.12.080
Autor:
Suresh Rudrapatana, Anandkumar Raichurkar, Vasan K. Sambandamurthy, Vikas Shinde, Sreevalli Sharma, Suresh Solapure, Prashanti Madhavapeddi, Gajanan Shanbhag, Dharmarajan Sriram, Vikas Patil, Radha Nandishaiah, Shahul Hameed P, Jayashree Puttur, Murugan Chinnapattu, C. N. Naveen Kumar, Praveena Manjrekar
Structure–activity relationship (SAR) exploration on the left-hand side (LHS) of a novel class of bacterial topoisomerase inhibitors led to a significant improvement in the selectivity against hERG cardiac channel binding with concomitant potent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac968c632a8bdcdbbc3e92c95d376ab6
https://europepmc.org/articles/PMC4499837/
https://europepmc.org/articles/PMC4499837/
Autor:
Sunita M. de Sousa, C. N. Naveen Kumar, Anandkumar Raichurkar, Kale Manoj Ganpat, Krishna Koushik, M. R. Manjunatha, David Waterson, Vasan K. Sambandamurthy, Vikas Shinde, K. N. Mahesh Kumar, Jitendar Reddy, Julie A. Tucker, Prashanti Madhavapeddi, Derek Ogg, Sandeep R. Ghorpade, Shubhada Barde, Halesha D. Basavarajappa, Shahul Hameed P, Samit Ganguly, V. K. Ramya, Lalit kumar Jena, Vijender Panduga, Vijaykamal Ahuja, Prakash Vachaspati, David C. McKinney, Jayashree Giridhar, Anirban Ghosh, Sheshagiri Gaonkar, Supreeth Guptha, P. Ann Boriack-Sjodin, Suresh Rudrapatna, Sreevalli Sharma, Usha Kranthi, Vaishali Humnabadkar
Publikováno v:
Journal of medicinal chemistry. 56(21)
A pharmacophore-based search led to the identification of thiazolopyridine ureas as a novel scaffold with antitubercular activity acting through inhibition of DNA Gyrase B (GyrB) ATPase. Evaluation of the binding mode of thiazolopyridines in a Mycoba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97722b62636e6c49a04e6567ae3fc13
https://pubmed.ncbi.nlm.nih.gov/24088190
https://pubmed.ncbi.nlm.nih.gov/24088190
Autor:
Lalit kumar Jena, Jitendar Reddy, Francesca Boldrin, Marcello Ventura, Ashwini Narayan, Meenakshi Mallya, Vasanthi Ramachandran, Ruben C. Hartkoorn, Shankar D. Markad, Riccardo Manganelli, Manoranjan Panda, Supreeth Guptha, Giulia Degiacomi, Neela Dinesh, Radha Shandil, Parvinder Kaur, Subramanyam J. Tantry, Sreenivasaiah Menasinakai, Chandan Narayan, Stewart T. Cole, Gajanan Shanbhag, Sreevalli Sharma, Sandeep R. Ghorpade, D. Bhattacharjee, Disha Awasthy, Gayathri Balakrishnan, C. N. Naveen Kumar
Whole cell based screens to identify hits against Mycobacterium tuberculosis (Mtb), carried out under replicating and non-replicating (NRP) conditions, resulted in the identification of multiple, novel but structurally related spiropiperidines with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925b3a26e2304af2cd90bde8b4ef3cc0
https://infoscience.epfl.ch/record/212051
https://infoscience.epfl.ch/record/212051