Výsledky vyhledávání - "C. N. Casciano"

The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein

Autor: E, Wang, C N, Casciano, R P, Clement, W W, Johnson

Publikováno v: Cancer research. 61(20)

P-glycoprotein (Pgp)-mediated drug efflux is a major factor contributing to the variance of absorption and distribution of many drugs, particularly cancer chemotherapeutics. Multidrug resistance (MDR) is caused largely by the efflux of therapeutics o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f220b78c529c519fcd1d6cac7717eca1
https://pubmed.ncbi.nlm.nih.gov/11606389

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In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes

Autor: M E, Barecki, C N, Casciano, W W, Johnson, R P, Clement

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(9)

The purpose of this study was to evaluate loratadine, desloratadine, and 3-OH-desloratadine as inhibitors of certain human liver cytochrome P-450 enzymes. Pooled human liver microsomes were used to determine whether loratadine, desloratadine, and 3-O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3921c85ccf44cf775c93e815be895589
https://pubmed.ncbi.nlm.nih.gov/11502723

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HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein

Autor: E, Wang, C N, Casciano, R P, Clement, W W, Johnson

Publikováno v: Pharmaceutical research. 18(6)

HMG-CoA reductase inhibitors (statins) are commonly prescribed for lipid lowering to treat hypercholesterolemia. Although they are well tolerated, their pharmacokinetic interactions with other drugs can lead to some adverse clinical consequences. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15f66866da225441d4e994144ea20973
https://pubmed.ncbi.nlm.nih.gov/11474784

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Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein

Autor: E J, Wang, C N, Casciano, R P, Clement, W W, Johnson

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(8)

The absorption of many drugs is affected by their interaction with ATP-binding cassette (ABC) transporters. The most extensively studied of these ABC transporters is the proein product of MDR1 (multidrug resistance) that encodes a 170-kDa integral pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b9c3e4ebc9fe4c6d45698e3fb5dc587
https://pubmed.ncbi.nlm.nih.gov/11454724

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Inhibition of P-glycoprotein transport function by grapefruit juice psoralen

Autor: E J, Wang, C N, Casciano, R P, Clement, W W, Johnson

Publikováno v: Pharmaceutical research. 18(4)

The grapefruit juice component bergamottin is known to inactivate cytochrome P450 3A4, with grapefruit juice consumption causing increased absorption and enhanced oral bioavailability of many cytochrome P450 3A4 substrates. Many of these substrates a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f4ee7bd6bea7938e18b60de53715ec3
https://pubmed.ncbi.nlm.nih.gov/11451028

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Mechanism-based inactivation of CYP2D6 by 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine

Autor: J R, Palamanda, C N, Casciano, L A, Norton, R P, Clement, L V, Favreau, C, Lin, A A, Nomeir

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(6)

SCH 66712 [5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine] caused a time- and NADPH-dependent loss of CYP2D6 activity. The inactivation of human liver (HL) microsomal dextromethorphan O-demethylase activity, a prototype ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac2f0d04fc0485be3ad4394d62a415a0
https://pubmed.ncbi.nlm.nih.gov/11353755

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Design and Conduct of Studies To Meet Residue Chemistry Requirements

Autor: R. P. Clement, R. D. Simmons, R. J. Christopher, S. F. Charles, C. N. Casciano, C. B. McCullough, J. F. Lamendola, M. N. Cayen

Publikováno v: ACS Symposium Series ISBN: 9780841224728

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2918d26efb90095618bec8e4926a3a9
https://doi.org/10.1021/bk-1992-0503.ch004

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Akademický článek

Carboranes as Potent Phenyl Mimetics: A Comparative Study on the Reversal of ABCG2-Mediated Drug Resistance by Carboranylquinazolines and Their Organic Isosteres.

Autor: Stockmann P; Faculty of Chemistry and Mineralogy, Leipzig University, Johannisallee 29, 04103, Leipzig, Germany., Kuhnert L; Faculty of Veterinary Medicine, Leipzig University, An den Tierkliniken 15, 04103, Leipzig, Germany., Krajnović T; Institute for Biological Research 'Sinisa Stankovic', University of Belgrade, Bul. despota Stefana 142, 11108, Belgrade, Serbia., Mijatović S; Institute for Biological Research 'Sinisa Stankovic', University of Belgrade, Bul. despota Stefana 142, 11108, Belgrade, Serbia., Maksimović-Ivanić D; Institute for Biological Research 'Sinisa Stankovic', University of Belgrade, Bul. despota Stefana 142, 11108, Belgrade, Serbia., Honscha W; Faculty of Veterinary Medicine, Leipzig University, An den Tierkliniken 15, 04103, Leipzig, Germany., Hey-Hawkins E; Faculty of Chemistry and Mineralogy, Leipzig University, Johannisallee 29, 04103, Leipzig, Germany.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Jan 15; Vol. 19 (2), pp. e202300506. Date of Electronic Publication: 2023 Dec 11.

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