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CEP-1347/KT7515 prevents motor neuronal programmed cell death and injury-induced dedifferentiationin vivo

Autor: Nicola Neff, M. A. Glicksman, Mark W. Harty, Arlene Y. Chiu, C. Murakata, J. L. Vaught, C. A. Dionne, Ronald W. Oppenheim, Dale R. Sengelaub, David Prevette, M. Kaneko

Publikováno v: Journal of Neurobiology. 35:361-370

CEP-1347, also known as KT7515, a derivative of a natural product indolocarbazole, inhibited motor neuronal death in vitro, inhibited activation of the stress-activated kinase JNK1 (c-jun NH terminal kinase) in cultured spinal motor neurons, but had

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54a70a16ae6eb8ef4c0345cd7d21f371
https://doi.org/10.1002/(sici)1097-4695(19980615)35:4<361::aid-neu3>3.0.co

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Preservation of cholinergic activity and prevention of neuron death by CEP-1347/KT-7515 following excitotoxic injury of the nucleus basalis magnocellularis

Autor: Nicola Neff, C. Murakata, A.M DiCamillo, Susan Carswell, E R Brown, Michael S. Saporito, J. L. Vaught, Matthew S. Miller, Haun Forrest A

Publikováno v: Neuroscience. 86:461-471

We have identified a class of small organic molecules, derived from the indolocarbazole K-252a, that promote the survival of cultured neurons. However, many of these indolocarbazoles inhibit protein kinase C and neurotrophin-activated tyrosine kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73169fee8fd53307ecb2f4484d5be7d0
https://doi.org/10.1016/s0306-4522(98)00059-1

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KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules

Autor: S, Soga, L M, Neckers, T W, Schulte, Y, Shiotsu, K, Akasaka, H, Narumi, T, Agatsuma, Y, Ikuina, C, Murakata, T, Tamaoki, S, Akinaga

Publikováno v: Cancer research. 59(12)

Radicicol, a macrocyclic antifungal antibiotic, has been shown to bind to the heat shock protein 90 (Hsp90) chaperone, interfering with its function. Hsp90 family chaperones have been shown to associate with several signaling molecules and play an es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cce2aad037bfbbe406b0bfa7df4eac5f
https://pubmed.ncbi.nlm.nih.gov/10383157

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Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555)

Autor: D J, George, C A, Dionne, J, Jani, T, Angeles, C, Murakata, J, Lamb, J T, Isaacs

Publikováno v: Cancer research. 59(10)

The indolocarbazole analogue CEP-751 is a potent and selective tyrosine kinase inhibitor of the neurotrophin-specific trk receptors that has demonstrated antitumor activity in nine different models of prostate cancer growth in vivo. In the slow-growi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a33645e030f6f0f7b93ef4cc3cc6297b
https://pubmed.ncbi.nlm.nih.gov/10344749

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In vitro and in vivo effects of KT6352, a derivative of indolocarbazole compounds, on murine megakaryocytopoiesis

Autor: Y, Shiotsu, S, Akinaga, K, Yamashita, C, Murakata, T, Tamaoki, Y, Ishida, S, Kuriya, M, Teramura, H, Mizoguchi

Publikováno v: Experimental hematology. 26(13)

We investigated the in vitro and in vivo effects of KT6352, a derivative of indolocarbazole compound, on murine megakaryocytopoiesis. When serum-free megakaryocyte (Meg) colony assay was performed with 100 U/mL of recombinant mouse interleukin-3 (rmI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26a1c73f618414d266c4ff33e747676f
https://pubmed.ncbi.nlm.nih.gov/9845374

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Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587)

Autor: C A, Dionne, A M, Camoratto, J P, Jani, E, Emerson, N, Neff, J L, Vaught, C, Murakata, D, Djakiew, J, Lamb, S, Bova, D, George, J T, Isaacs

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(8)

Advanced prostate cancer remains largely incurable, primarily because the very low growth fraction present in these tumors makes them generally resistant to treatment with standard chemotherapeutic agents that target cell division. Effective therapie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64f054496ada1cba06ef506e915d9c08
https://pubmed.ncbi.nlm.nih.gov/9717816

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CEP-1347/KT7515 prevents motor neuronal programmed cell death and injury-induced dedifferentiation in vivo

Autor: M A, Glicksman, A Y, Chiu, C A, Dionne, M, Harty, M, Kaneko, C, Murakata, R W, Oppenheim, D, Prevette, D R, Sengelaub, J L, Vaught, N T, Neff

Publikováno v: Journal of neurobiology. 35(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99e6e5723fceecbe5548f20adef991eb
https://pubmed.ncbi.nlm.nih.gov/9624618

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CEP-751 inhibits TRK receptor tyrosine kinase activity in vitro exhibits anti-tumor activity

Autor: A M, Camoratto, J P, Jani, T S, Angeles, A C, Maroney, C Y, Sanders, C, Murakata, N T, Neff, J L, Vaught, J T, Isaacs, C A, Dionne

Publikováno v: International journal of cancer. 72(4)

The present report describes the in vitro and in vivo profile of CEP-751, a novel receptor tyrosine kinase inhibitor. CEP-751 at 100 nM inhibits the receptor tyrosine kinase activity of the neurotrophin receptors trkA, trkB and trkC. CEP-751 has no e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e5257ae37f467e345c5207fb3aaab63
https://pubmed.ncbi.nlm.nih.gov/9259409

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KT-5720 reverses multidrug resistance in variant S49 mouse lymphoma cells transduced with the human MDR1 cDNA and in human multidrug-resistant carcinoma cells

Autor: Philip Lazarovici, H. Galski, C. Murakata, Jacob Hochman, Y. Matsuda, M.M. Gottesman

Publikováno v: European journal of cancer (Oxford, England : 1990). (3)

T-25-Adh cells, cell variants derived from S49 mouse lymphoma, were transduced with a retrovirus containing the human MDR1 cDNA. The resultant cells (HU-1) are cross-resistant to colchicine, doxorubicin, vinblastine and actinomycin D, and their resis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38d21455a632dcdb5a85169f0c20e25
https://pubmed.ncbi.nlm.nih.gov/7786606

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Potent selective inhibition of 7-O-methyl UCN-01 against protein kinase C

Autor: I, Takahashi, E, Kobayashi, H, Nakano, C, Murakata, H, Saitoh, K, Suzuki, T, Tamaoki

Publikováno v: The Journal of pharmacology and experimental therapeutics. 255(3)

UCN-01 is a staurosporine-related compound that was isolated from the culture broth of Streptomyces sp. and shows potent and selective inhibitory activity against protein kinase C. Cellular inhibitory activity of UCN-01 against protein kinase C and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4cc9747919db5fa06c44c3274efb4028
https://pubmed.ncbi.nlm.nih.gov/2262903

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