Zobrazeno 1 - 10
of 1 397
pro vyhledávání: '"C. Munshi"'
Autor:
Xiang Zhou, Patrick Costello, Anita Schmitt, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt, Max Topp, Hartmut Goldschmidt, Hermann Einsele, Nikhil C Munshi, Marc S Raab, Joseph Kauer, Thomas Hielscher, Niels Weinhold, Mirco J Friedrich, Sandra Sauer, Leo Rasche, Thomas Luft, Jan H Frenking, Vivien Wagner, Elias K Mai, Christian S Michel, Marina Hajiyianni, Iris Breitkreutz, Omar Nadeem, Adam S Sperling
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 10 (2024)
Background Chimeric antigen receptor (CAR) T-cell therapy has demonstrated significant benefits in the treatment of relapsed/refractory multiple myeloma (RRMM). However, these outcomes can be compromised by severe complications, including cytokine re
Externí odkaz:
https://doaj.org/article/8940433ced884d68a993840e8bd1f4cb
Autor:
Moritz Binder, Raphael E. Szalat, Srikanth Talluri, Mariateresa Fulciniti, Hervé Avet-Loiseau, Giovanni Parmigiani, Mehmet K. Samur, Nikhil C. Munshi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The natural history of multiple myeloma is characterized by its localization to the bone marrow and its interaction with bone marrow stromal cells. The bone marrow stromal cells provide growth and survival signals, thereby promoting the deve
Externí odkaz:
https://doaj.org/article/9ae3e3ccba2e4821b3f01ffba88946f8
Autor:
Anil Aktas Samur, Mariateresa Fulciniti, Herve Avet-Loiseau, Michael A. Lopez, Sanika Derebail, Jill Corre, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Kenneth C. Anderson, Giovanni Parmigiani, Mehmet K. Samur, Nikhil C. Munshi
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 12, Pp 1-11 (2022)
Abstract Splicing changes are common in cancer and are associated with dysregulated splicing factors. Here, we analyzed RNA-seq data from 323 newly diagnosed multiple myeloma (MM) patients and described the alternative splicing (AS) landscape. We obs
Externí odkaz:
https://doaj.org/article/8f433518944f46019120b39f11b9a13b
Autor:
Vanessa K. Favasuli, Domenica Ronchetti, Ilaria Silvestris, Noemi Puccio, Giuseppina Fabbiano, Valentina Traini, Katia Todoerti, Silvia Erratico, Alessia Ciarrocchi, Valentina Fragliasso, Domenica Giannandrea, Francesca Tumiatti, Raffaella Chiaramonte, Yvan Torrente, Palma Finelli, Eugenio Morelli, Nikhil C. Munshi, Niccolò Bolli, Antonino Neri, Elisa Taìana
Publikováno v:
Haematologica, Vol 109, Iss 1 (2023)
DIS3 gene mutations occur in approximately 10% of patients with multiple myeloma (MM); furthermore, DIS3 expression can be affected by monosomy 13 and del(13q), found in roughly 40% of MM cases. Despite the high incidence of DIS3 mutations and deleti
Externí odkaz:
https://doaj.org/article/0b1c35b936fb4637b779ba411fdb0591
Autor:
Eugenio Morelli, Zachary R. Hunter, Mariateresa Fulciniti, Annamaria Gullà, Ida Daniela Perrotta, Valeria Zuccalà, Cinzia Federico, Giada Juli, Martina Manzoni, Domenica Ronchetti, Enrica Romeo, Maria Eugenia Gallo Cantafio, Debora Soncini, Lorenza Maltese, Marco Rossi, Aldo M. Roccaro, Michele Cea, Pierfrancesco Tassone, Antonino Neri, Steven C. Treon, Nikhil C. Munshi, Giuseppe Viglietto, Nicola Amodio
Publikováno v:
Experimental Hematology & Oncology, Vol 11, Iss 1, Pp 1-6 (2022)
Abstract Activating G protein-coupled estrogen receptor 1 (GPER1) is an attractive therapeutic strategy for treating a variety of human diseases including cancer. Here, we show that GPER1 is significantly upregulated in tumor cells from different coh
Externí odkaz:
https://doaj.org/article/8e2f2cc9b27d46db8aa9ce4fa5663b16
Autor:
Srikanth Talluri, Mehmet K. Samur, Leutz Buon, Subodh Kumar, Lakshmi B. Potluri, Jialan Shi, Rao H. Prabhala, Masood A. Shammas, Nikhil C. Munshi
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 10, Pp 1-11 (2021)
Abstract Multiple myeloma (MM) is a heterogeneous disease characterized by significant genomic instability. Recently, a causal role for the AID/APOBEC deaminases in inducing somatic mutations in myeloma has been reported. We have identified APOBEC/AI
Externí odkaz:
https://doaj.org/article/d13895ee298b46c692921d6655cf5d13
Autor:
Jennifer Derrien, Catherine Guérin-Charbonnel, Victor Gaborit, Loïc Campion, Magali Devic, Elise Douillard, Nathalie Roi, Hervé Avet-Loiseau, Olivier Decaux, Thierry Facon, Jan-Philipp Mallm, Roland Eils, Nikhil C. Munshi, Philippe Moreau, Carl Herrmann, Florence Magrangeas, Stéphane Minvielle
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-21 (2021)
Abstract Background Cancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor evolution have been investigated mostly from a genetic perspective. Methods Here, we performed an
Externí odkaz:
https://doaj.org/article/4a911b1129d149468316660d33d6e2e4
Autor:
Subodh Kumar, Leutz Buon, Srikanth Talluri, Marco Roncador, Chengcheng Liao, Jiangning Zhao, Jialan Shi, Chandraditya Chakraborty, Gabriel Gonzalez, Yu-Tzu Tai, Rao Prabhala, Mehmet K. Samur, Nikhil C. Munshi, Masood A. Shammas
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Subodh Kumar et al. identify a gene signature correlated with genomic instability and poor survival in esophageal adenocarcinoma (EAC), using a combination of integrative genomic analysis of patient data and laboratory validation in cell line models
Externí odkaz:
https://doaj.org/article/6f113318075d4e0bb3590bebd59eb8e1
Autor:
Mehmet Kemal Samur, Mariateresa Fulciniti, Anil Aktas Samur, Abdul Hamid Bazarbachi, Yu-Tzu Tai, Rao Prabhala, Alejandro Alonso, Adam S. Sperling, Timothy Campbell, Fabio Petrocca, Kristen Hege, Shari Kaiser, Hervé Avet Loiseau, Kenneth C. Anderson, Nikhil C. Munshi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Relapse following BCMA targeted CAR T-cell therapy is frequently observed in patients with multiple myeloma (MM). Here, by single cell transcriptome profiling on serially collected bone marrow samples, the authors report biallelic loss of BCMA as the
Externí odkaz:
https://doaj.org/article/d60d813fb4064441b48a7626818c3ce7
Autor:
Tarek H. Mouhieddine, Adam S. Sperling, Robert Redd, Jihye Park, Matthew Leventhal, Christopher J. Gibson, Salomon Manier, Amin H. Nassar, Marzia Capelletti, Daisy Huynh, Mark Bustoros, Romanos Sklavenitis-Pistofidis, Sabrin Tahri, Kalvis Hornburg, Henry Dumke, Muhieddine M. Itani, Cody J. Boehner, Chia-Jen Liu, Saud H. AlDubayan, Brendan Reardon, Eliezer M. Van Allen, Jonathan J. Keats, Chip Stewart, Shaadi Mehr, Daniel Auclair, Robert L. Schlossman, Nikhil C. Munshi, Kenneth C. Anderson, David P. Steensma, Jacob P. Laubach, Paul G. Richardson, Jerome Ritz, Benjamin L. Ebert, Robert J. Soiffer, Lorenzo Trippa, Gad Getz, Donna S. Neuberg, Irene M. Ghobrial
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Multiple myeloma (MM) is treated with induction chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. Here, the authors show that the presence of clonal haematopoiesis of indeterminate potential
Externí odkaz:
https://doaj.org/article/26a4f18ed00849e6bce820eacad6b32d