Výsledky vyhledávání - "C. Moratilla"

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IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer

Autor: Rosario Machado-Pinilla, Manuel Nistal, Inmaculada Ibáñez de Cáceres, C. Moratilla, Rosario Perona, Cristobal Belda-Iniesta, Paloma Cejas, Luis Paz-Ares, Cristina Manguan-García, Fernando Lopez-Rios, María Cortes-Sempere, V. Rodriguez-Fanjul, J de Castro-Carpeño

Publikováno v: Oncogene. 29:1681-1690

Cisplatin-based chemotherapy is the paradigm of non-small-cell lung cancer (NSCLC) treatment; however, it also induces de novo DNA-hypermethylation, a process that may be involved in the development of drug-resistant phenotypes by inactivating genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53f45cdf7e995a7c5375afaf047c4b3
https://doi.org/10.1038/onc.2009.454

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MKP1/CL100 controls tumor growth and sensitivity to cisplatin in non-small-cell lung cancer

Autor: Rosario Machado-Pinilla, J A Fresno-Vara, J de Castro-Carpeño, Paloma Cejas, Rosario Perona, M. Nistal, Cristobal Belda-Iniesta, Cristina Manguan-García, Enrique Casado, S. Chattopadhyay, C. Moratilla, Manuel González-Barón

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Non-small-cell lung cancer (NSCLC) represents the most frequent and therapy-refractive sub-class of lung cancer. Improving apoptosis induction in NSCLC represents a logical way forward in treating this tumor. Cisplatin, a commonly used therapeutic ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878a75c991bd9395d25cc335e9b300c4
https://doi.org/10.1038/sj.onc.1209364

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High resolution melting analysis for the identification of novel mutations in DKC1 and TERT genes in patients with dyskeratosis congenita

Autor: S. Martín-Sala, Leandro Sastre, M. Aymerich, Cristina Manguan-García, P. Martínez, C. Moratilla, J. Solera, L. Canal, L. Escoda, J.L. Dapena, Julián Sevilla, Jaime Carrillo, J.M. García-Sagredo, S. Rives, Andrea González, M. del Campo, Rosario Perona

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Dyskeratosis congenita (DC) is a rare inherited bone-marrow failure syndrome with high clinical heterogeneity. Cells derived from DC patients present short telomeres at early ages, as a result of mutations in genes encoding components of the telomera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2adbe8a3ffc126864b4a04499e4ad2
http://hdl.handle.net/10261/77016

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Pulmonary diffusing capacity in chronic dialysis patients

Autor: C. Moratilla, J. A. Herrero, C. Gámez, José Luis Álvarez-Sala, A. Barrientos, F. Coronel, J.M.F. Sánchez-Alarcos

Publikováno v: Respiratory medicine. 96(7)

Patients with end-stage renal disease treated by hemodialysis with bioincompatible membranes are exposed during the dialysis period to acute effects on lung microcirculation, which may result in pulmonary fibrosis and diffusion defects in long-standi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9284dbaf3468607993242be4c9b67f19
https://pubmed.ncbi.nlm.nih.gov/12194631

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Identification of drug-sensitive prediction genes by an epigenetic reactivation screen of cisplatin-resistant NSCLC cell lines

Autor: I. Ibanez de Caceres, C. Moratilla, M. Cortes Sempere, R. Machado-Pinilla, V. Rodriguez-Fanjul, C. Manguan, J. de Castro Carpeño, C. Belda-Iniesta C, P. Cejas, R. Perona

Publikováno v: European Journal of Cancer Supplements. 6:106-107

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdcc4f1ad6fe4ece900e42988e351af1
https://doi.org/10.1016/s1359-6349(08)71582-9

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Apoptosis induced by protein kinase C inhibition in a neuroblastoma cell line

Autor: M M, Behrens, J L, Martínez, C, Moratilla, J, Renart

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 6(11)

The protein kinase C inhibitor bisindolylmaleimide GF109203X has a dual effect on the behavior of the neuroblastoma cell line Neuro-2A; when the inhibitor is added in conditions that induce differentiation (absence of serum), neurite outgrowth is pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c71b064c2c83e60e070fe0b05c0c463
https://pubmed.ncbi.nlm.nih.gov/8562475

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P-103 Role of JNK/MKP1 and PI3K/NF B on response of non-small cell lung carcinoma (NSCLC) cells to cisplatin

Autor: Joan Albanell, J. A. Fresno, M. Tapia, Ana Rovira, Paloma Cejas, C. Moratilla, J. de Castro, C. Manguan, Rosario Perona, S. Chattopadhyay, Rogério Bonassi Machado, M. Nistal, Cristobal Belda-Iniesta, Manuel González Barón

Publikováno v: Lung Cancer. 49:S141

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bc131930706f31a03f6840ec7fc71ec
https://doi.org/10.1016/s0169-5002(05)80597-5

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77 MKP-1/CL 100 activity modulates cisplatin responses in non-small cell lung carcinoma

Autor: M. Gonzalez-Barón, Rosario Perona, Paloma Cejas, M. Nistal, R. Machado, S. Chattopadhyay, C. Belda, J A Fresno-Vara, C. Moratilla

Publikováno v: European Journal of Cancer Supplements. 2:27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::140f99799ba3b2801e293a0bb847e3ca
https://doi.org/10.1016/s1359-6349(04)80085-5

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