Zobrazeno 1 - 10
of 427
pro vyhledávání: '"C. Merrick"'
Autor:
Jennifer Chu, Wenhan Zhang, Regina Cencic, Patrick B.F. O’Connor, Francis Robert, William G. Devine, Asher Selznick, Thomas Henkel, William C. Merrick, Lauren E. Brown, Pavel V. Baranov, John A. Porco, Jr., Jerry Pelletier
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2481-2488.e5 (2020)
Summary: Rocaglates are a diverse family of biologically active molecules that have gained tremendous interest in recent years due to their promising activities in pre-clinical cancer studies. As a result, this family of compounds has been significan
Externí odkaz:
https://doaj.org/article/21a67c621b25477f8f89045cf022ad46
Publikováno v:
Age and Ageing. 51
Background Identification of different groups at risk of frailty is a key research focus. Farmers frequently have higher prevalence of some health problems; however, they undertake high levels of physical activity which may provide protection against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cffe5f33622d3b40bb5c85e4bbe48c9
https://doi.org/10.1093/ageing/afac218.314
https://doi.org/10.1093/ageing/afac218.314
Publikováno v:
New Directions for Teaching and Learning. 2021:11-23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beaf81d425ae532a02eaf4e64dd9cf10
https://doi.org/10.1002/tl.20433
https://doi.org/10.1002/tl.20433
Autor:
William C. Merrick, Pavel Ivanov, Yasutoshi Akiyama, Sandeep Ojha, Dhwani Dave, Vladimir B. Tsvetkov, Shawn M. Lyons, Prakash Kharel, Paul A. Anderson
Publikováno v:
Nucleic Acids Research
As cells encounter adverse environmental conditions, such as hypoxia, oxidative stress or nutrient deprivation, they trigger stress response pathways to protect themselves until transient stresses have passed. Inhibition of translation is a key compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfb6f8150a0ed82b9a9009392cb0033
https://doi.org/10.1093/nar/gkaa336
https://doi.org/10.1093/nar/gkaa336
Autor:
Nicholas J. Hargus, Ellen C. Merrick, Aradhya Nigam, Christopher L. Kalmar, Aparna R. Baheti, Edward H. Bertram, III, Manoj K. Patel
Publikováno v:
Neurobiology of Disease, Vol 41, Iss 2, Pp 361-376 (2011)
Temporal lobe epilepsy (TLE) is the most common form of adult epilepsy involving the limbic structures of the temporal lobe. Layer II neurons of the entorhinal cortex (EC) form the major excitatory input into the hippocampus via the perforant path an
Externí odkaz:
https://doaj.org/article/7bb21c258a2641f49a1c1973e1b99a18
Autor:
Dawid Krokowski, Raul Jobava, Krzysztof J. Szkop, Chien-Wen Chen, Xu Fu, Sarah Venus, Bo-Jhih Guan, Jing Wu, Zhaofeng Gao, Wioleta Banaszuk, Marek Tchorzewski, Tingwei Mu, Phil Ropelewski, William C. Merrick, Yuanhui Mao, Aksoylu Inci Sevval, Helen Miranda, Shu-Bing Qian, Maria Manifava, Nicholas T. Ktistakis, Anastasios Vourekas, Eckhard Jankowsky, Ivan Topisirovic, Ola Larsson, Maria Hatzoglou
Publikováno v:
Cell reports. 40(3)
The integrated stress response (ISR) plays a pivotal role in adaptation of translation machinery to cellular stress. Here, we demonstrate an ISR-independent osmoadaptation mechanism involving reprogramming of translation via coordinated but independe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9662af6eaaa76ac3d1b9b00163da785d
https://pubmed.ncbi.nlm.nih.gov/35858571
https://pubmed.ncbi.nlm.nih.gov/35858571
Autor:
Anton A. Komar, Anchal Agarwal, Bo-Jhih Guan, Roman V. Kondratov, David A. Buchner, Arnab Ghosh, Maria Hatzoglou, William C. Merrick, Barsanjit Mazumder, William M. Baldwin, Nina Dvorina, Taras Y. Nazarko, Jackson Casteel, Richard Anderson
Publikováno v:
FASEB J
Eukaryotic initiation factor 2A (eIF2A) is a 65 kDa protein that functions in minor initiation pathways, which affect the translation of only a subset of messenger ribonucleic acid (mRNAs), such as internal ribosome entry site (IRES)-containing mRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac66b9b54643b870d0a87ab9b8883b0
https://europepmc.org/articles/PMC8848898/
https://europepmc.org/articles/PMC8848898/
Autor:
Jordan D Carelli, Steven G Sethofer, Geoffrey A Smith, Howard R Miller, Jillian L Simard, William C Merrick, Rishi K Jain, Nathan T Ross, Jack Taunton
Publikováno v:
eLife, Vol 4 (2015)
Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of terna
Externí odkaz:
https://doaj.org/article/3d339e5f72f041a19390a1c696c97ca6
Autor:
Mario Servulo Izidoro, Masaaki Sokabe, Nancy Villa, William C. Merrick, Christopher S. Fraser
Publikováno v:
The Journal of biological chemistry, vol 298, iss 10
During translation initiation, the underlying mechanism by which the eukaryotic initiation factor (eIF) 4E, eIF4A, and eIF4G components of eIF4F coordinate their binding activities to regulate eIF4F binding to mRNA is poorly defined. Here, we used fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4fc85b16e09043ce88a98da9606b77
https://doi.org/10.1016/j.jbc.2022.102368
https://doi.org/10.1016/j.jbc.2022.102368
Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress
Autor:
Yuanhui Mao, Dawid Krokowski, Erica Shu, Di Hu, Raul Jobava, Eckhard Jankowsky, Evelyn Chukwurah, Leah L. Zagore, Xin Qi, Youwei Zhang, Shu-Bing Qian, Ivan Topisirovic, Zhaofeng Gao, Donny D. Licatalosi, Bo-Jhih Guan, William C. Merrick, Maria Hatzoglou, Jing Wu
SummaryMammalian cells have to adapt to environmental challenges that range from mild to severe stress. While the cellular response to mild stress has been widely studied, how cells respond to severe stress remains unclear. We show here that under se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02576d50ca6841d07d773357c0d278c4
https://doi.org/10.1101/2020.10.10.334375
https://doi.org/10.1101/2020.10.10.334375