Zobrazeno 1 - 10
of 82
pro vyhledávání: '"C. Melcion"'
Autor:
Elmar Gocke, C. Melcion, Takehiko Nohmi, Toshihiro Ohta, E. Zeiger, L. Kier, S. Venitt, D. Gatehouse, T. Cebula, T. Matsushima, S. Haworth
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects. 312:217-233
At the International Workshop on the Standardisation of Genotoxicity Test Procedures, in Melbourne (27-28 February 1993), the current international guidelines for the correct conduct of bacterial mutation assays were considered, and the major differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe0a1bf16ee8553c483127f8883e31c
https://doi.org/10.1016/0165-1161(94)90037-x
https://doi.org/10.1016/0165-1161(94)90037-x
Publikováno v:
Mutagenesis. 9:199-204
In order to validate the in vivo micronucleus test in mouse splenocytes using the cytokinesis block method, 14 compounds with various mechanisms of action were tested: three direct alkylating agents (mitomycin C, ethylnitrosourea, beta-propiolactone)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7df7ce44f43c489c09f2310ae886361
https://doi.org/10.1093/mutage/9.3.199
https://doi.org/10.1093/mutage/9.3.199
Autor:
Nicole Bichet, Christophe Chesne, Georges de Sousa, Alain Fautrel, J. Pichon, M. Placidi, G. Lorenzon, C. Melcion, Marc Benicourt, Roger Rahmani, André Cordier, André Guillouzo, Robert Fournex, Françoise Braut, Daniel Gouy, Pascale Vintèzou, H. Hoellinger
Publikováno v:
Alternatives to Laboratory Animals. 21:281-284
A multicentre validation study of the acute in vitro cytotoxicities of 31 liquid or solid chemicals was carried out by six laboratories, using primary rat hepatocyte cultures as a model system. We report here a comparison of neutral red uptake IC50 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60c9bdf11cae57bc44e885f924604b94
https://doi.org/10.1177/026119299302100223
https://doi.org/10.1177/026119299302100223
Autor:
Marc Benicourt, H. Hoellinger, Robert Fournex, J. Pichon, F. Braut, Alain Fautrel, P. Vintezou, A.F. Peloux, M. Placidi, Daniel Gouy, R. Lounes, Jean-Paul Cano, Roger Rahmani, C. Melcion, Christophe Chesne, André Cordier, B. Vannier, I. Diarte, G. de Sousa, André Guillouzo, G. Lorenzon, Nicole Bichet
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 5(5-6)
A multicentre validation study of the acute in vitro cytotoxicity of drugs involving six French laboratories from INSERM or pharmaceutical companies has been carried out. Thirty liquid or solid chemicals such as antibiotics, anticancer drugs and solv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb29207d8e2a77f2d940b48f579d250d
https://pubmed.ncbi.nlm.nih.gov/20732074
https://pubmed.ncbi.nlm.nih.gov/20732074
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 4(4-5)
The purpose of this work was to compare yield, attachment rate and specific metabolic functions (stimulation of ketone body production by glucagon) of human hepatocytes isolated from surgical biopsies and from organ donor livers cold stored with a mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed087d47a9165d16754e0f65260a80bb
https://pubmed.ncbi.nlm.nih.gov/20702208
https://pubmed.ncbi.nlm.nih.gov/20702208
Autor:
Cornelia Niemann, Marie-Agnès Ivanov, Lysiane Richert, André Cordier, Jean-Charles Gauthier, C. Melcion
Publikováno v:
Biochemical Pharmacology. 42:373-379
The stabilities of several drug oxidation and conjugation pathways in adult rat hepatocytes were investigated in two systems: a primary pure culture lasting 3 days and a primary mixed culture (hepatocytes co-cultured with epithelial cells) lasting 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a59f35baf09a80c8c5a48ae3e4f80005
https://doi.org/10.1016/0006-2952(91)90725-k
https://doi.org/10.1016/0006-2952(91)90725-k
Autor:
Jean Michel Caillaud, Jean Francois Leonard, André Cordier, Herve P. Brun, Valerie Moronvalle, C. Melcion
Publikováno v:
Toxicology and Applied Pharmacology. 108:307-320
In vivo studies have shown that the testis is a target organ for drugs and chemicals. In order to evaluate the testicular toxicity of compounds and to identify the mechanisms of their toxicity, we have developed a miniaturized primary culture of imma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0332ac4cae49329c8eba05c87e41e6
https://doi.org/10.1016/0041-008x(91)90120-4
https://doi.org/10.1016/0041-008x(91)90120-4
Publikováno v:
Mutation research. 292(2)
In vivo somatic chromosome mutation tests are usually carried out using the bone marrow micronucleus test in the mouse. This test is also considered predictive for the study of clastogenic effects in germ cells. However, it has been reported that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d3f0cd2369012f4cd9760c5edc518a
https://pubmed.ncbi.nlm.nih.gov/7692246
https://pubmed.ncbi.nlm.nih.gov/7692246
Publikováno v:
Mutation research. 280(2)
A micronucleus detection test using mouse splenocytes has been adapted from a method previously carried out using human lymphocytes. An ex vivo protocol was chosen: male C57B16 mice were treated with various compounds. Splenocytes were then isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a436b550b363540398c532897076106e
https://pubmed.ncbi.nlm.nih.gov/1378538
https://pubmed.ncbi.nlm.nih.gov/1378538
The cytotoxic potential of 28 molecules was determined, by a cell viability test, on a rat hepatocyte monolayer culture, on a porcine Leydig cell culture and on an epithelial cell line of CH0-K1 cells. In 65% of the cases, the results were identical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9549343c5762c554ae9153fa866c74bf
https://doi.org/10.1016/b978-0-7506-0421-5.50153-7
https://doi.org/10.1016/b978-0-7506-0421-5.50153-7
