Zobrazeno 1 - 10
of 119
pro vyhledávání: '"C. Mark Smales"'
Autor:
Tobias von der Haar, Thomas E. Mulroney, Fabio Hedayioglu, Sathishkumar Kurusamy, Maria Rust, Kathryn S. Lilley, James E. Thaventhiran, Anne E. Willis, C. Mark Smales
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
In vitro transcribed, modified messenger RNAs (IVTmRNAs) have been used to vaccinate billions of individuals against the SARS-CoV-2 virus, and are currently being developed for many additional therapeutic applications. IVTmRNAs must be translated int
Externí odkaz:
https://doaj.org/article/a6fe20fc312948cb980fb2feac3e94c1
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/5fe0d1af7759426b87c0785f4dd93616
Autor:
Niamh Murphy, Barrie Rooney, Tapan Bhattacharyya, Omar Triana-Chavez, Anja Krueger, Stuart M. Haslam, Victoria O’Rourke, Magdalena Pańczuk, Jemima Tsang, Jack Bickford-Smith, Robert H. Gilman, Kevin Tetteh, Chris Drakeley, C. Mark Smales, Michael A. Miles
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Chagas disease is considered the most important parasitic disease in Latin America. The protozoan agent, Trypanosoma cruzi, comprises six genetic lineages, TcI-TcVI. Genotyping to link lineage(s) to severity of cardiomyopathy and gastrointes
Externí odkaz:
https://doaj.org/article/165e40f9f490492697ff2f1922192a35
Autor:
James D. Budge, Joanne Roobol, Gurdeep Singh, Théo Mozzanino, Tanya J. Knight, Jane Povey, Andrew Dean, Sarah J. Turner, Colin M. Jaques, Robert J. Young, Andrew J. Racher, C. Mark Smales
Publikováno v:
Metabolic Engineering Communications, Vol 13, Iss , Pp e00179- (2021)
Chinese hamster ovary (CHO) cells are the leading mammalian cell host employed to produce complex secreted recombinant biotherapeutics such as monoclonal antibodies (mAbs). Metabolic selection marker technologies (e.g. glutamine synthetase (GS) or di
Externí odkaz:
https://doaj.org/article/e27fed91ce824e5dab7f3f8f5797933c
Autor:
John R. P. Knight, Gavin Garland, Tuija Pöyry, Emma Mead, Nikola Vlahov, Aristeidis Sfakianos, Stefano Grosso, Fabio De-Lima-Hedayioglu, Giovanna R. Mallucci, Tobias von der Haar, C. Mark Smales, Owen J. Sansom, Anne E. Willis
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 3 (2020)
Regulation of protein synthesis makes a major contribution to post-transcriptional control pathways. During disease, or under stress, cells initiate processes to reprogramme protein synthesis and thus orchestrate the appropriate cellular response. Re
Externí odkaz:
https://doaj.org/article/a2935a80c20d4745bd899b8125296c87
Autor:
Davide Vito, Jens Christian Eriksen, Christian Skjødt, Dietmar Weilguny, Søren K. Rasmussen, C. Mark Smales
Publikováno v:
iScience, Vol 23, Iss 1, Pp - (2020)
Summary: How the long non-coding RNA (lncRNA) genome in recombinant protein producing Chinese hamster ovary (CHO) cell lines relates to phenotype is not well described. We therefore defined the CHO cell lncRNA transcriptome from cells grown in contro
Externí odkaz:
https://doaj.org/article/715ccdf3618c421e9f5254716f80e698
Autor:
Jane F. Povey, Emily Saintas, Adewale V. Aderemi, Florian Rothweiler, Richard Zehner, Wilhelm G. Dirks, Jindrich Cinatl, Andrew J. Racher, Mark N. Wass, C. Mark Smales, Martin Michaelis
Publikováno v:
Cells, Vol 8, Iss 10, p 1194 (2019)
The use of cell lines in research can be affected by cell line misidentification. Short tandem repeat (STR) analysis is an effective method, and the gold standard, for the identification of the genetic origin of a cell line, but methods that allow th
Externí odkaz:
https://doaj.org/article/e0e65e6b34f749d0945ee5dee0856040
Autor:
Theodoros Kontogiannis, Julian Braybrook, Christopher McElroy, Carole Foy, Alexandra S. Whale, Milena Quaglia, C Mark Smales
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101309- (2024)
Standardized evaluation of adeno-associated virus (AAV) vector products for biotherapeutic application is essential to ensure the safety and efficacy of gene therapies. This includes analyzing the critical quality attributes of the product. However,
Externí odkaz:
https://doaj.org/article/2f88b3c6abda45aba14c0ea6e2e7acf1
Publikováno v:
Biotechnology Letters. 45:425-437
Exosomes have previously been isolated from Chinese hamster ovary (CHO) cells and their anti-apoptotic properties reported. However, to further facilitate the study of CHO cell derived exosomes and allow their comparison across studies, it is necessa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6acfc36e6b0b91398eee1133b106e5c
https://doi.org/10.1007/s10529-023-03353-3
https://doi.org/10.1007/s10529-023-03353-3
Autor:
James D. Budge, Tanya J. Knight, Jane Povey, Joanne Roobol, Ian R. Brown, Gurdeep Singh, Andrew Dean, Sarah Turner, Colin M. Jaques, Robert J. Young, Andrew J. Racher, C Mark Smales
Publikováno v:
Data in Brief, Vol 29, Iss , Pp - (2020)
The data presented in this article relates to the manuscript entitled ‘Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production’, published in the Journal Meta
Externí odkaz:
https://doaj.org/article/32d14f1acc3b4dd5998f753bc5772db3