Zobrazeno 1 - 10
of 20
pro vyhledávání: '"C. Mark Ensor"'
Publikováno v:
Angewandte Chemie. 120:3778-3781
Autor:
John S. Bomalaski, C. Mark Ensor, Maurizio Montella, Gerardo Beneduce, Guglielmo Nasti, Fabrizio Scordino, Antonio Pio Orlando, Mike A. Clark, F. Cremona, Raffaele Orlando, Giuseppe Castello, Frederick W. Holtzberg, Francesco Izzo, Brent E. Korba, Steven A. Curley
Publikováno v:
Journal of Gastroenterology and Hepatology. 22:86-91
Background: The arginine-degrading enzyme, arginine deiminase conjugated to polyethylene glycol (ADI-SS PEG 20 000 mw), reduces extracellular arginine, has minimal toxicity, decreases tumor burden and improves liver function in patients with chronic
Autor:
Giuseppe Castello, Frederick W. Holtsberg, Paolo Marra, John S. Bomalaski, Steven A. Curley, Chaan S. Ng, Francesco Izzo, Vincenzo De Rosa, Paolo Vallone, Gerardo Beneduce, Mike A. Clark, C. Mark Ensor, Franco Cremona
Publikováno v:
Journal of Clinical Oncology. 22:1815-1822
Purpose Recently, we reported that a large number of human hepatocellular cancer (HCC) cell lines were auxotrophic for arginine. Here we report the results obtained with the amino acid–degrading enzyme arginine deiminase (ADI) conjugated to polyeth
Autor:
Mike A. Clark, Frederick W. Holtsberg, John S. Bomalaski, Victor G. Prieto, C. Mark Ensor, Brian J. Dillon, Steven A. Curley
Publikováno v:
Cancer. 100:826-833
BACKGROUND Argininosuccinate synthetase (ASS) was the first of two enzymes to convert citrulline to arginine. This pathway allowed cells to synthesize arginine from citrulline, making this amino acid nonessential for the growth of most mammalian cell
Publikováno v:
Biochemical Journal. 363:581-587
Septic shock is mediated in part by nitric oxide (NO) and tumour necrosis factor α (TNFα). NO is synthesized primarily from extracellular arginine. We tested the ability of an arginine-degrading enzyme to inhibit NO production in mice and to protec
Autor:
Patrizia Pasini, Sylvia Daunert, Leonidas G. Bachas, Krystal Teasley Hamorsky, C. Mark Ensor, Emre Dikici
Hydroxylated polychlorinated biphenyls (OH-PCBs) are an important class of contaminants that mainly originate from polychlorinated biphenyl metabolism. They may conceivably be as dangerous and persistent as the parent compounds; most prominently, OH-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cad48c457d9a83a5f1e49bf5ecdcdef
https://europepmc.org/articles/PMC4127403/
https://europepmc.org/articles/PMC4127403/
Autor:
Emre Dikici, Krystal Teasley Hamorsky, Bruce R. Branchini, Sylvia Daunert, C. Mark Ensor, Audrey L. Davis
Publikováno v:
Chemiluminescence and Bioluminescence ISBN: 9781847558121
Genetic and biomolecular engineering are two of the leading disciplines in biotechnology that have lead to great advancements in protein engineering. Applications of analytical bioluminescence, such as genetic reporter assays, optical in vivo imaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0bd8fffe999459ca897f67c03450757
https://doi.org/10.1039/9781849732024-00443
https://doi.org/10.1039/9781849732024-00443
Publikováno v:
Analytical chemistry. 82(11)
Herein, we report the development of a novel, inexpensive, and portable filter-paper-based strip biosensor for the detection of bacterial quorum sensing signaling molecules, N-acylhomoserine lactones (AHLs). AHLs are generally employed by Gram-negati
Autor:
Stefania Scala, Vincenzo De Rosa, Mike A. Clark, Giuseppe Castello, Maria Teresa Melucci, Theodore F. Logan, Francesco Izzo, C. Mark Ensor, Antonio Daponte, Paolo A. Ascierto, Frederick W. Holtsberg, John S. Bomalaski, Niramol Savaraj, Alessandro Ottaiano, Archie W. Prestayko, Lynn G. Feun, Gerardo Beneduce, Ester Simeone
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 23(30)
Purpose Individuals with metastatic melanoma have a poor prognosis. Many human melanomas are auxotrophic for arginine, and arginine is not an essential amino acid in humans. We hypothesized that this auxotrophy may be therapeutically exploited. A nov
Publikováno v:
Hepato-gastroenterology. 50(53)
We report the first pharmacokinetic and clinical response data from a patient with unresectable hepatocellular cancer treated with a new drug, ADI PEG20,000 mw (arginine deiminase-polyethylene glycol 20,000 molecular weight). A single patient with id