Výsledky vyhledávání - "C. Malaveille"

Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans

Autor: Sisko Anttila, A.-M. Camus, Marcel Castegnaro, C. Malaveille, Helmut Bartsch, Eino Hietanen, Margarita Rojas, K Hirvonen, Kroum Alexandrov, Kirsti Husgafvel-Pursiainen

Publikováno v: Pharmacogenetics. 5:S84-S90

A case-control study on lung cancer patients demonstrated the pronounced effect of tobacco smoke on pulmonary carcinogen metabolism and suggested the existence of a metabolic phenotype at higher risk for tobacco-associated lung cancer. Lung cancer pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef975f3f4de34c5c3f9b28f4aa2a5050
https://doi.org/10.1097/00008571-199512001-00007

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Combined effect of polymorphic GST genes on individual susceptibility to lung cancer

Autor: S T, Saarikoski, A, Voho, M, Reinikainen, S, Anttila, A, Karjalainen, C, Malaveille, H, Vainio, K, Husgafvel-Pursiainen, A, Hirvonen

Publikováno v: International journal of cancer. 77(4)

Glutathione S-transferases (GSTs) are known to take part in detoxification of many potentially carcinogenic compounds. Therefore, polymorphisms of the GST genes have been considered as potentially important modifiers of individual risk of environment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed4ff7be580bbd9e822f19f5b3d65c70
https://pubmed.ncbi.nlm.nih.gov/9679751

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Cytochrome P4501A2: enzyme induction and genetic control in determining 4-aminobiphenyl-hemoglobin adduct levels

Autor: M T, Landi, C, Zocchetti, I, Bernucci, F F, Kadlubar, S, Tannenbaum, P, Skipper, H, Bartsch, C, Malaveille, P, Shields, N E, Caporaso, P, Vineis

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 5(9)

Cytochrome P4501A2 (CYP1A2) activity may be related to bladder cancer risk through metabolic activation of aromatic amines, such as 4-aminobiphenyl (ABP), to reactive intermediates that can form DNA and hemoglobin (Hb) adducts. In the context of a st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2b1c66a450f9dd415b59f65a3ed3f17
https://pubmed.ncbi.nlm.nih.gov/8877060

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In vivo nitrosoproline formation and other risk factors in Costa Rican children from high- and low-risk areas for gastric cancer

Autor: R, Sierra, A, Chinnock, H, Ohshima, B, Pignatelli, C, Malaveille, C, Gamboa, S, Teuchmann, N, Muñoz, H, Bartsch

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2(6)

The hypothesis that intragastric synthesis of N-nitroso compounds (NOC) in early life could play a role in gastric carcinogenesis was tested by applying the N-nitrosoproline (NPRO) test to about 50 children living in high- and low-risk areas for stom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1bea70c29f2b057aa1c4efe87213f667
https://pubmed.ncbi.nlm.nih.gov/8268774

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Detection of carcinogen-DNA adducts in exfoliated urothelial cells of cigarette smokers: association with smoking, hemoglobin adducts, and urinary mutagenicity

Autor: G, Talaska, M, Schamer, P, Skipper, S, Tannenbaum, N, Caporaso, L, Unruh, F F, Kadlubar, H, Bartsch, C, Malaveille, P, Vineis

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 1(1)

The presence of covalent modifications in DNA obtained from exfoliated urothelial cells of smokers and nonsmokers was determined using 32P postlabeling methods. Urine and blood samples were procured from 73 persons. Cells were removed from the urine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef1ab4b989fe7782d49c588679f7b914
https://pubmed.ncbi.nlm.nih.gov/1845172

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Genotoxicity of ochratoxin A and structurally related compounds in Escherichia coli strains: studies on their mode of action

Autor: C, Malaveille, G, Brun, H, Bartsch

Publikováno v: IARC scientific publications. (115)

Ochratoxin A, ochratoxin alpha (its major metabolite in rodents) and seven structurally related substances were assayed for SOS DNA repair inducing activity in Escherichia coli PQ37 strain. At a concentration range of 0.1-4 mM, ochratoxin A, chloroxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24c4149428c888a0891f807dac5eef89
https://pubmed.ncbi.nlm.nih.gov/1820340

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Exposure to N-nitrosamines and other risk factors for gastric cancer in Costa Rican children

Autor: R, Sierra, H, Ohshima, N, Muñoz, S, Teuchmann, A S, Peña, C, Malaveille, B, Pignatelli, A, Chinnock, F, el Ghissassi, C, Chen

Publikováno v: IARC scientific publications. (105)

The hypothesis that endogenous chemical nitrosation in the normal stomach in early life could play a crucial role in inducing chronic atrophic gastritis/intestinal metaplasia in later life was tested by applying the N-nitrosoproline (NPRO) test to 12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2b09f2b530ef307f666a2e361a206aa
https://pubmed.ncbi.nlm.nih.gov/1855842

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Epstein-Barr virus activators, mutagens and volatile nitrosamines in preserved food samples from high-risk areas for nasopharyngeal carcinoma

Autor: G, Bouvier, S, Poirier, Y M, Shao, C, Malaveille, H, Ohshima, A, Polack, G W, Bornkamm, Y, Zeng, G, de-Thé, H, Bartsch

Publikováno v: IARC scientific publications. (105)

Representative samples of preserved foods collected from high-risk areas for nasopharyngeal carcinoma were assayed for capacity to induce Epstein-Barr virus (EBV) by measuring induction of the DR promoter gene or of genes for early antigens in Raji c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8907ee215a4d5e38b46f26f5cd50f787
https://pubmed.ncbi.nlm.nih.gov/1649791

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N-nitroso compounds, genotoxins and their precursors in gastric juice from humans with and without precancerous lesions of the stomach

Autor: B, Pignatelli, C, Malaveille, C, Chen, A, Hautefeuille, P, Thuillier, N, Muñoz, B, Moulinier, F, Berger, H, De Montclos, H, Ohshima

Publikováno v: IARC scientific publications. (105)

We are investigating the interrelationships between levels of total N-nitroso compounds (NOC), genotoxic activity (both before and after nitrosation), degree of bacterial colonization in gastric juice and degree of severity or absence of precancerous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26206801e9049aac2187e457e19a9922
https://pubmed.ncbi.nlm.nih.gov/1855844

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