Zobrazeno 1 - 10
of 194
pro vyhledávání: '"C. Macaluso"'
Autor:
Long T. Nguyen, Nicolas C. Macaluso, Noah R. Rakestraw, Dylan R. Carman, Brianna L.M. Pizzano, Raymond C. Hautamaki, Santosh R. Rananaware, Isabel E. Roberts, Piyush K. Jain
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113777- (2024)
Summary: There is a broad diversity among Cas12a endonucleases that possess nucleic acid detection and gene-editing capabilities, but few are studied extensively. Here, we present an exhaustive investigation of 23 Cas12a orthologs, with a focus on th
Externí odkaz:
https://doaj.org/article/fa7c464d82e7437d8bba5ed5f812778d
Autor:
Santosh R. Rananaware, Emma K. Vesco, Grace M. Shoemaker, Swapnil S. Anekar, Luke Samuel W. Sandoval, Katelyn S. Meister, Nicolas C. Macaluso, Long T. Nguyen, Piyush K. Jain
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Cas12a, a CRISPR-associated protein complex, has an inherent ability to cleave DNA substrates and is utilized in diagnostic tools to identify DNA molecules. We demonstrate that multiple orthologs of Cas12a activate trans-cleavage in the pres
Externí odkaz:
https://doaj.org/article/39af6d98bb7648069f26b3fe592cdc59
Autor:
Long T. Nguyen, Nicolas C. Macaluso, Brianna L.M. Pizzano, Melanie N. Cash, Jan Spacek, Jan Karasek, Megan R. Miller, John A. Lednicky, Rhoel R. Dinglasan, Marco Salemi, Piyush K. Jain
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103926- (2022)
Summary: Background: Current SARS-CoV-2 detection platforms lack the ability to differentiate among variants of concern (VOCs) in an efficient manner. CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated) based dete
Externí odkaz:
https://doaj.org/article/a18b5fd53c4f44029ae374b24230bf7a
Autor:
Chan-Wen Chiu, Minghan Xian, Jenna L. Stephany, Xinyi Xia, Chao-Ching Chiang, Fan Ren, Cheng-Tse Tsai, Siang-Sin Shan, Yu-Te Liao, Josephine F. Esquivel-Upshaw, Santosh R. Rananaware, Long T. Nguyen, Nicolas C. Macaluso, Piyush K. Jain, Melanie N. Cash, Carla N. Mavian, Marco Salemi, Marino E. Leon, Chin-Wei Chang, Jenshan Lin, Stephen J. Pearton
Publikováno v:
J Vac Sci Technol B Nanotechnol Microelectron
The SARS-CoV-2 pandemic has had a significant impact worldwide. Currently, the most common detection methods for the virus are polymerase chain reaction (PCR) and lateral flow tests. PCR takes more than an hour to obtain the results and lateral flow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390e4833665d5af909e7c0195f2a575e
https://europepmc.org/articles/PMC8830941/
https://europepmc.org/articles/PMC8830941/
Autor:
Long T. Nguyen, Santosh R. Rananaware, Lilia G. Yang, Nicolas C. Macaluso, Julio E. Ocana-Ortiz, Katelyn S. Meister, Brianna L.M. Pizzano, Luke Samuel W. Sandoval, Raymond C. Hautamaki, Zoe R. Fang, Sara M. Joseph, Grace M. Shoemaker, Dylan R. Carman, Liwei Chang, Noah R. Rakestraw, Jon F. Zachary, Sebastian Guerra, Alberto Perez, Piyush K. Jain
Publikováno v:
SSRN Electronic Journal.
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based diagnostics have elevated nucleic acid detection in terms of sensitivity, specificity, and rapidity in recent years. CRISPR-Cas systems can be combined with a pre-amplification
Autor:
AU Wells, Sujal R. Desai, Cjw Stock, PL Molyneaux, Felix Chua, G Margaritopoulos, C Macaluso, EA Renzoni, Peter M. George, A Devaraj, Toby M. Maher, C Boccabella, Vasilis Kouranos, Maria Kokosi, Gisli Jenkins
Publikováno v:
Assessing, managing and predicting outcomes in ILD.
Autor:
Long T, Nguyen, Nicolas C, Macaluso, Brianna L M, Pizzano, Melanie N, Cash, Jan, Spacek, Jan, Karasek, Rhoel R, Dinglasan, Marco, Salemi, Piyush K, Jain
Publikováno v:
medRxiv : the preprint server for health sciences.
Current SARS-CoV-2 detection platforms lack the ability to differentiate among variants of concern (VOCs) in an efficient manner. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) has the potential to transform diagnostics due to its
Reliable, efficient, and cheap detection of infectious diseases, especially in the wake of the SARS-CoV-2 pandemic, is of increasing importance. CRISPR/Cas systems have the capabilities to be optimized for this purpose. There is a broad diversity amo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed751dfa4f8548f4e50f03a7c1535e31
https://doi.org/10.1101/2021.07.21.21260653
https://doi.org/10.1101/2021.07.21.21260653
Autor:
Jan Spacek, Melanie N. Cash, Nicolas C. Macaluso, Jan Karasek, Rhoel R. Dinglasan, Marco Salemi, Piyush K. Jain, Long T. Nguyen, Brianna L.M. Pizzano
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Current SARS-CoV-2 detection platforms lack the ability to differentiate among variants of concern (VOCs) in an efficient manner. CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated) based detection systems have th
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