Inhibition of stimulated Jurkat cell adenosine 3',5'-cyclic monophosphate synthesis by the immunomodulatory compound HR325

Autor: A P, Curnock, T A, Thomson, R, Westwood, E A, Kuo, R A, Williamson, C M, Yea, E, Ruuthb

Publikováno v: Biochemical pharmacology. 61(2)

HR325 (2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'(trifluoromethyl)-phenyl]-propenamide) is an immunomodulatory compound through pyrimidine biosynthesis inhibition with antiproliferative properties which was derived from the isoxazol compound A77

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2062666249248a5a516772e012297b5
https://pubmed.ncbi.nlm.nih.gov/11163337

Dihydroorotate dehydrogenase is a target for the biological effects of leflunomide

Autor: R A, Williamson, C M, Yea, P A, Robson, A P, Curnock, S, Gadher, A B, Hambleton, K, Woodward, J M, Bruneau, P, Hambleton, S, Spinella-Jaegle, P, Morand, O, Courtin, C, Sautés, R, Westwood, T, Hercend, E A, Kuo, E, Ruuth

Publikováno v: Transplantation proceedings. 28(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::750bde00bce34adf3759b41e9842c707
https://pubmed.ncbi.nlm.nih.gov/8962196

Identification of a myeloperoxidase inhibitor from normal human serum

Autor: Christopher J. Elson, B Dularay, C. M. Yea

Publikováno v: Clinical and experimental immunology. 84(2)

SUMMARY An inhibitor of myeloperoxidase (MPO) has been identified in normal human serum. Initial experiments confirmed that high levels of MPO inhibitory activity are present in sera and that the inhibitor did not act by interfering with the assay. P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856bd62b850679ecf93c466ef027cf45
https://pubmed.ncbi.nlm.nih.gov/1851058

KVD900, an oral on-demand treatment for hereditary angioedema: Phase 1 study results

Autor: Maetzel, Andreas, Smith, Michael D., Duckworth, Edward J., Hampton, Sally L., De Donatis, Gian Marco, Murugesan, Nivetha, Rushbrooke, Louise J., Li, Lily, Francombe, Danielle, Feener, Edward P., Yea, Christopher M.

Publikováno v: In The Journal of Allergy and Clinical Immunology June 2022 149(6):2034-2042

Transition-Metal-Free Radical Relay Cascade Annulation of Amides: Access to Antitumor Active Benzo[b]azepine and Oxindole Derivatives.

Autor: Sheng XX; Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, 21 Gehu Road, Changzhou, 213164, China., Qiu CY; Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, 21 Gehu Road, Changzhou, 213164, China., Wang LN; Department of Clinical and Military Laboratory Medicine, College of Medical Laboratory Science, Army Medical University, No. 30 Gaotanyan Street, Chongqing, 400038, China., Du YJ; Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, 21 Gehu Road, Changzhou, 213164, China., Tang LN; Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, 21 Gehu Road, Changzhou, 213164, China., Chen JM; Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, 21 Gehu Road, Changzhou, 213164, China., Liu GY; Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, 21 Gehu Road, Changzhou, 213164, China., Yang S; Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, 21 Gehu Road, Changzhou, 213164, China., Zheng PF; College of Pharmacy, Army Medical University, No. 30 Gaotanyan Street, Chongqing, 400038, China., Chen M; Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, 21 Gehu Road, Changzhou, 213164, China.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Nov 12; Vol. 30 (63), pp. e202402402. Date of Electronic Publication: 2024 Oct 26.