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Autor:
Heinrich J. Schostarez, R. A. Poorman, J. W. Wilks, Vincent P. Marshall, C. M. Trepod, G. L. Petzold, John E. Mott, G. F. Hess, G.L. Bryant Jr, T. J. O'Sullivan, Barry C. Finzel, M. A. Mitchell, Eric T. Baldwin
Publikováno v:
Protein Science. 7:2118-2126
The binding of two 5-substituted-1,3,4-thiadiazole-2-thione inhibitors to the matrix metalloproteinase stromelysin (MMP-3) have been characterized by protein crystallography. Both inhibitors coordinate to the catalytic zinc cation via an exocyclic su