Výsledky vyhledávání - "C. M. Siegmann"

C17-substituted 5- and 5(10)-estrenes and their 7α-methyl homologues

Autor: C. C. Bolt, F. J. Zeelen, H. P. de Jongh, N. P. Van Vliet, C. M. Siegmann

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 88:1061-1069

17α-Alkylated derivatives of 5-estren-17β-ol and their 7α-methyl homologues have been prepared (Chart I). The key step in these syntheses is the reduction of the 3β-chloro-5-estrenes (IV) with lithium in liquid ammonia. Similar derivatives of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f9c588e2edae182de2e19b8b5abf5ef
https://doi.org/10.1002/recl.19690880906

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Total synthesis in the steroid series. III: Synthesis of aldosterone

Autor: O. Schindler, W. J. van der Burg, D. A. van Dorp, C. M. Siegmann, S. A. Szpilfogel

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 77:171-176

The transformation of the substituted D-homoandrostane derivative IV (see preceding paper) into a known aldosterone intermediate is described.

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https://doi.org/10.1002/recl.19580770209

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Total synthesis in the steroid series. I. An tricyclic intermediate to 18-oxygenated steroids. d,l-Δ8a-4bβ-Methyl-2β-formyl-2α-(3′-oxopropyl)-7-ethylenedioxy-4aα,10aβ-dodecahydrophenanthrene-4β-ol-l-one)

Autor: S. A. Szpilfogelw, J. H. N. van der Burg, D. A. van Dorp, C. M. Siegmann

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 75:1043-1052

The total synthesis of racemic aldosterone (I) was achieved recently by J. Schmidlin, G. Anner, J.-R. Billeter and A. Wettstein1 . Our own efforts in the field of the total synthesis of adrenal cortical hormones and derivatives will be described in t

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https://doi.org/10.1002/recl.19560750906

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Total synthesis in the steroid series. II: d,l −3-ethylenedioxy-11 β-hydroxy-17-oxymethyl-D-homoandrosta-5: 16-diene 18-acid lactone (18 → 11), an intermediate to aldosterone

Autor: C. M. Siegmann, W. J. van der Burg, S. A. Szpilfogel, D. A. van Dorp

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 77:157-170

Attempts to transform potential intermediates prepared earlier into 18-oxygenated steroids are described. One of the routes lead to the substiuted D-homoandrostane derivative (XXIX) mentioned in the title.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94db1b173e974c3855185cd6dd65ae04
https://doi.org/10.1002/recl.19580770208

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Transformations of 3,17-Dioxo-Δ4-Androsten-19-al to estrane derivatives

Autor: M. S. de Winter, C. M. Siegmann

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 89:442-448

3,17-Dioxo-Δ4-androsten-19-al (II) is a suitable starting material for the preparation of estrane derivatives. Autoxidation gives the corresponding 10β-hydroperoxide III, which can be converted to estrone (V) by reduction and aromatization. Treatme

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https://doi.org/10.1002/recl.19700890502

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The sterical structure of tropinol and pseudo-tropinol

Autor: C. M. Siegmann, J. H. Wisse, H. C. Beyerman, F. L. J. Sixma

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 75:1445-1453

In a preliminary communication 1 some of us have reported on the rates of alkaline hydrolysis of the benzoic and p-nitrobenzoic esters of tropinol and ψ-tropinol and of their methiodides in aqueous ethanol. It is shown in the present investigation,

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https://doi.org/10.1002/recl.19560751212

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6α- and 6β-methyl steroids in the 19-nor series

Autor: C. M. Siegmann, C. C. Bolt, A. J. van den Broek, G. Heijmens Visser, H. P. de Jongh

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 90:849-860

The dehydration-epimerization reaction applied to a 5α-hydroxy-6β-methyl-3-oxo-19-nor-steroid, under acid conditions, leads to a mixture of the 6α-methyl-3-oxo-Δ4-19-nor-steroid and its 6β-epimer. This is in contrast to the normal steroid series

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99839c27fc7c1176284a9b2d11920ff1
https://doi.org/10.1002/recl.19710900804

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Synthesis and some pharmacological properties of esters of some n-alkyl homologues of tropinol and ψ-tropinol: 3rd Communication on Derivatives of Tropinols

Autor: C. M. Siegmann, J. P. Wibaut

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 73:203-217

The syntheses described are those of a number of homologues of tropinone, viz. N-ethyl-nor-tropinone, N-n-propyl-nor-tropinone, N-iso-propyl-nor-tropinone, and of a number of tropinols, viz. N-ethyl-norψ-tropinol, N-ethyl-nor-ψ-tropinol, N-n-propyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb0150e5ea14d7a8e12369db998f1dc5
https://doi.org/10.1002/recl.19540730306

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