Zobrazeno 1 - 10
of 22
pro vyhledávání: '"C. M. Pickart"'
Autor:
R J Mayer, C M Pickart, Michael Landon, Robert Layfield, Robert Ramage, Andrew Alban, Y A Lam, C Jamieson
Publikováno v:
Proceedings of the National Academy of Sciences. 97:9902-9906
Alzheimer's disease is the most common cause of dementia in the elderly. Although several genetic defects have been identified in patients with a family history of this disease, the majority of cases involve individuals with no known genetic predispo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ef0bb8a8dbbddf7b5dd903c0d63610
https://doi.org/10.1073/pnas.170173897
https://doi.org/10.1073/pnas.170173897
Publikováno v:
Cell. 105(6)
While the signaling properties of ubiquitin depend on the topology of polyubiquitin chains, little is known concerning the molecular basis of specificity in chain assembly and recognition. UEV/Ubc complexes have been implicated in the assembly of Lys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6aa67fcd84ca9539431d721e5e849486
https://pubmed.ncbi.nlm.nih.gov/11440714
https://pubmed.ncbi.nlm.nih.gov/11440714
Autor:
C. M. Pickart
Publikováno v:
Stress Proteins ISBN: 9783642635199
Cells respond to stresses such as elevated temperature, heavy metals, and amino acid analogs by inducing the transcription of a set of genes whose products, known as stress proteins, enhance survival under stress conditions. The major shared property
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::967f7c72d79fb220be5e5df7a2eca3b2
https://doi.org/10.1007/978-3-642-58259-2_6
https://doi.org/10.1007/978-3-642-58259-2_6
Publikováno v:
The Journal of biological chemistry. 269(10)
Ubiquitin-mediated proteolysis proceeds via the formation and degradation of ubiquitin-protein conjugates. Ubiquitin (Ub)-activating enzyme (E1) catalyzes the first, MgATP-dependent step in the conjugative reaction sequence. With wild type ubiquitin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77be7259507bd90e305af9f9ccdb3c01
https://pubmed.ncbi.nlm.nih.gov/8125920
https://pubmed.ncbi.nlm.nih.gov/8125920
Publikováno v:
The Journal of biological chemistry. 267(23)
Covalent ligation of multiubiquitin chains targets eukaryotic proteins for degradation. In such multiubiquitin chains, successive ubiquitins are linked by an isopeptide bond involving the side chain of Lys48 and the carboxyl group of Gly76. The cryst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb2410db949de9b02e1ec55ab98cf0d7
https://pubmed.ncbi.nlm.nih.gov/1322903
https://pubmed.ncbi.nlm.nih.gov/1322903
Publikováno v:
The Journal of biological chemistry. 267(23)
Trivalent arsenoxides bind to vicinal thiol groups of proteins. We showed previously that the simplest trivalent arsenoxide, inorganic arsenite, inhibits ubiquitin-dependent protein degradation in rabbit reticulocyte lysate (Klemperer, N.S., and Pick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c6a68aee9c95cfa3e7d63768020774d
https://pubmed.ncbi.nlm.nih.gov/1644825
https://pubmed.ncbi.nlm.nih.gov/1644825
Publikováno v:
The Journal of biological chemistry. 267(20)
Covalent ligation of multiubiquitin chains targets eukaryotic proteins for degradation. Ubiquitin-conjugating enzyme E2(25K) utilizes isolated ubiquitin as the substrate for synthesis of such chains, in which successive ubiquitin units are linked by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b61440a884b65f6bc63120afd8e8a6d
https://pubmed.ncbi.nlm.nih.gov/1321147
https://pubmed.ncbi.nlm.nih.gov/1321147
Publikováno v:
The Journal of biological chemistry. 266(24)
The ubiquitin (Ub)-conjugating enzyme E2(25K) catalyzes the synthesis of multi-Ub chains in which successive Ub units are linked by an isopeptide bond involving the epsilon-amino group of Lys-48 of Ubn, and the COOH-terminal Gly residue of Ubn+1 (Che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b81a9068845ca711e9f813bb0a593f9
https://pubmed.ncbi.nlm.nih.gov/1714895
https://pubmed.ncbi.nlm.nih.gov/1714895
Autor:
Z, Chen, C M, Pickart
Publikováno v:
The Journal of biological chemistry. 265(35)
Target protein multi-ubiquitination involving lysine 48 of ubiquitin (Ub) is known to occur during protein degradation in the ATP- and Ub-dependent proteolytic pathway (Chau, V., Tobias, J. W., Bachmair, A., Marriott, D., Ecker, D. J., Gonda, D. K.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9fa454b707f06252ab8c8c5215ca53a
https://pubmed.ncbi.nlm.nih.gov/2174887
https://pubmed.ncbi.nlm.nih.gov/2174887
Autor:
I A Rose, C M Pickart
Publikováno v:
Journal of Biological Chemistry. 260:1573-1581
In the formation of covalent ubiquitin-protein conjugates that occurs during ATP- and ubiquitin-dependent proteolysis in reticulocyte extracts, ubiquitin (Ub) is activated to a thiol ester of the activating enzyme E1 (via the Ub carboxyl terminus), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1af813e158b76b43fce5f22eecb60a58
https://doi.org/10.1016/s0021-9258(18)89632-6
https://doi.org/10.1016/s0021-9258(18)89632-6