Zobrazeno 1 - 10
of 27
pro vyhledávání: '"C. M. Knudson"'
Autor:
D T Rutkowski, C M Knudson, Sean M. Martin, Tomomi Kuwana, Oksana Zagorodna, Douglas R. Spitz
Publikováno v:
Oncogene
Targeting altered cancer cell metabolism with the glycolysis inhibitor, 2-deoxyglucose (2DG), is a viable therapeutic strategy, but the effects of 2DG on lymphoma cells and the mechanism of action are unknown. Five T-cell lymphoma lines and two B-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8560c291ef498d19b2790d40ed25fc34
http://europepmc.org/articles/PMC3257357
http://europepmc.org/articles/PMC3257357
Autor:
Stanley J. Korsmeyer, C M Knudson
Publikováno v:
Nature Genetics. 16:358-363
The BCL-2 family has various pairs of antagonist and agonist proteins that regulate apoptosis. Whether their function is interdependent is uncertain. Using a genetic approach to address this question, we utilized gain- and loss-of-function models of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06dfc3daf1a8d72116ebd2ec2cca9443
https://doi.org/10.1038/ng0897-358
https://doi.org/10.1038/ng0897-358
Publikováno v:
Journal of Biological Chemistry. 268:12637-12645
Monoclonal antibodies were used to identify a 94-kDa protein that was greatly enriched in traids and junctional face membranes (9.3 +/- 0.2%) but not detected in the transverse tubular and nonjunctional sarcoplasmic reticulum membranes. The 94-kDa pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77a383554ca31847f62dda5f52df5976
https://doi.org/10.1016/s0021-9258(18)31436-4
https://doi.org/10.1016/s0021-9258(18)31436-4
Publikováno v:
Journal of Biological Chemistry. 268:12646-12654
The primary amino acid sequence for a highly abundant junctional sarcoplasmic reticulum glycoprotein (triadin) has been deduced from the cDNA sequence. Based on both biochemical analysis and the predicted amino acid sequence we suggest that this prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f84540623c172b684baaa942b3b17c9
https://doi.org/10.1016/s0021-9258(18)31437-6
https://doi.org/10.1016/s0021-9258(18)31437-6
Publikováno v:
Journal of Biological Chemistry. 265:2421-2424
Sarcoplasmic reticulum isolated from malignant hyperthermia-susceptible (MHS) muscle exhibits abnormalities in the regulation of calcium release. To identify the molecular basis of this abnormality, the Ca2+ release channel from both normal and MHS s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62682be5329f6ed0061b3d46df925370
https://doi.org/10.1016/s0021-9258(19)39813-8
https://doi.org/10.1016/s0021-9258(19)39813-8
Publikováno v:
Cancer research. 61(2)
Bax is a Bcl-2 family member that promotes apoptosis and counters the protective effect of Bcl-2. Bax is a downstream effector of p53-induced apoptosis and is transcriptionally regulated by p53. Moreover, the introduction of Bax deficiency accelerate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be5519e81dd8f277f2fe79bbb9daf7d5
https://pubmed.ncbi.nlm.nih.gov/11212265
https://pubmed.ncbi.nlm.nih.gov/11212265
Autor:
K, Schorr, M, Li, U, Bar-Peled, A, Lewis, A, Heredia, B, Lewis, C M, Knudson, S J, Korsmeyer, R, Jäger, H, Weiher, P A, Furth
Publikováno v:
Cancer research. 59(11)
The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50% during the first stage and increased cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f719273ee62fd63dcdbf57c901edf005
https://pubmed.ncbi.nlm.nih.gov/10363969
https://pubmed.ncbi.nlm.nih.gov/10363969
Autor:
R S, Hotchkiss, P E, Swanson, C M, Knudson, K C, Chang, J P, Cobb, D F, Osborne, K M, Zollner, T G, Buchman, S J, Korsmeyer, I E, Karl
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(7)
In sepsis there is extensive apoptosis of lymphocytes, which may be beneficial by down-regulating the accompanying inflammation. Alternatively, apoptosis may be detrimental by impairing host defense. We studied whether Bcl-2, a potent antiapoptotic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1d303a33fcb7be01b1bc4e2f6ebeedf0
https://pubmed.ncbi.nlm.nih.gov/10201940
https://pubmed.ncbi.nlm.nih.gov/10201940
Publikováno v:
Investigative ophthalmologyvisual science. 39(9)
Bax, a member of the Bcl2 family of cell death regulators, induces cell death by promoting the induction of apoptosis. Bax-deficient mice were examined in this study to determine whether Bax is required for cell death in the developing retina and for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b80cddbe6ff199ba6dfea349dcb6e68
https://pubmed.ncbi.nlm.nih.gov/9699561
https://pubmed.ncbi.nlm.nih.gov/9699561
Publikováno v:
Nature. 385(6617)
The protein p53 is a key tumour-suppressor, as evidenced by its frequent inactivation in human cancers. Animal models have indicated that attenuation of p53-dependent cell death (apoptosis) can contribute to both the initiation and progression of can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdedae13f3fabdf9f2c5aa2ac7fb5f5
https://pubmed.ncbi.nlm.nih.gov/9024662
https://pubmed.ncbi.nlm.nih.gov/9024662