Zobrazeno 1 - 10
of 15
pro vyhledávání: '"C. M. Herd"'
Autor:
C. M. Herd, Clive P. Page, Mark A. Giembycz, Maria G. Belvisi, Domenico Spina, Hema J Patel, G J Douglas, P. J. Barnes
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 12:245-255
We have assessed the effect of sensitization to allergen on airway smooth muscle responsiveness and acetylcholine (ACh) release from cholinergic nerves in tracheal preparations from rabbits immunized at birth to Alternaria tenuis and littermate contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26acc0288352abcdb2692af95617172
https://doi.org/10.1006/pupt.1999.0204
https://doi.org/10.1006/pupt.1999.0204
Autor:
C. M. Herd, Mark Holbrook, A. Z. El-Hashim, Clive P. Page, S.M. Blake, Gerry Higgs, Neil Gozzard, B. Hughes
Publikováno v:
British Journal of Pharmacology. 118:1201-1208
1. The effects of the inhaled corticosteroid budesonide and a novel PDE 4 inhibitor CDP840 given systematically, were evaluated in a model of antigen-induced airway inflammation in the rabbit. 2. Adult litter-matched NZW rabbits (2.4-3.5 kg) immunise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9038ff00c0878537a58db4ba387cab8f
https://doi.org/10.1111/j.1476-5381.1996.tb15524.x
https://doi.org/10.1111/j.1476-5381.1996.tb15524.x
Publikováno v:
European Journal of Pharmacology. 282:111-119
The effect of a 3-day pre-treatment regime of capsaicin (8-methyl-N-vanillyl-6-nonenamide) (80 mg/kg s.c.) on airway changes induced by Alternaria tenuis aerosol challenge 3 days later was assessed in adult rabbits immunised from birth to the age of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ef1c1bde0db3f1454587afe931da44
https://doi.org/10.1016/0014-2999(95)00291-r
https://doi.org/10.1016/0014-2999(95)00291-r
Publikováno v:
British Journal of Pharmacology. 112:292-298
1. The effect of a single intratracheal dose (10 mg) of PF 5901 (2-[3(1-hydroxyhexyl) phenoxymethyl] quinoline hydrochloride, a specific inhibitor of the 5-lipoxygenase pathway of arachidonic acid metabolism and a leukotriene D4 antagonist) on airway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd483c8b0e171cc0fca7803771232f9
https://doi.org/10.1111/j.1476-5381.1994.tb13067.x
https://doi.org/10.1111/j.1476-5381.1994.tb13067.x
Publikováno v:
King's College London
Background Animal models of allergy and bronchial hyperresponsiveness (BHR) are useful in researching pulmonary diseases and evaluating drug effects on the airways. Neonatally immunised rabbits exhibit several features of asthma as adults, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0908ebc3bbc5dfeb277075b7ab07f8
https://pubmed.ncbi.nlm.nih.gov/21854860
https://pubmed.ncbi.nlm.nih.gov/21854860
Publikováno v:
British Journal of Pharmacology. 107:1108-1115
1. Aerosol administration of platelet activating factor (PAF) (80 micrograms ml-1 for 60 min) to neonatally immunized rabbits caused bronchoconstriction which was far in excess of that produced by a comparable aerosol of bovine serum albumin (BSA), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296e6cbe662b15c81b9dd13afa060300
https://doi.org/10.1111/j.1476-5381.1992.tb13415.x
https://doi.org/10.1111/j.1476-5381.1992.tb13415.x
1. The effects of the xanthine, theophylline, a non-selective phosphodiesterase (PDE) inhibitor, and the phosphodiesterase type 4 (PDE 4) inhibitor, rolipram, were evaluated in a model of antigen-induced airway responses in the allergic rabbit. 2. Ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8edc7df30f62b8203df33ff27c4e1f
https://europepmc.org/articles/PMC1909441/
https://europepmc.org/articles/PMC1909441/
Autor:
C. M. Herd, Clive P. Page
Publikováno v:
Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo ISBN: 9783034898638
The prevalence and incidence of atopy and asthma is increasing in the industrialized world, particularly amongst children [1, 2]. Asthma is a chronic disease characterized by a variety of features including reversible airway obstruction, increased ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e1df05d3caf7180ba384ad98194ae95
https://doi.org/10.1007/978-3-0348-9000-7_7
https://doi.org/10.1007/978-3-0348-9000-7_7
Autor:
Clive P. Page, C. M. Herd
Publikováno v:
Immunopharmacology of Platelets ISBN: 9780123901200
Publisher Summary This chapter discusses the role of platelets in allergic inflammation. The chapter suggests that the fundamental physiological role of the platelet within the mammalian circulation is in the defence of the host against invasion by f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcd8211de9ff1877ed7b33fbdcbe15bc
https://doi.org/10.1016/b978-012390120-0/50003-4
https://doi.org/10.1016/b978-012390120-0/50003-4
1. PF 10040 displaced [3H]-PAF from binding sites on rabbit platelets with an IC50 = 1.07 x 10(-5) M, which was approximately three orders of magnitude below that of a standard PAF antagonist WEB 2086 (IC50 = 4.23 x 10(-9) M). 2. PF 10040 at doses of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddf05bf22bd8b257356d99a35136e14
https://europepmc.org/articles/PMC1910040/
https://europepmc.org/articles/PMC1910040/