Výsledky vyhledávání - "C. M. G. Sunnen"

Fine-mapping of the B-cell epitope domain at the N-terminus of the preS2 region of the hepatitis B surface antigen

Autor: Juris Jansons, Wolfram H. Gerlich, C. M. G. Sunnen, Dirk Sobotta, Irina Sominskaya, Dzidra Dreilina, W. P. Paulij, Paul Pumpens, Helga Meisel

Publikováno v: Journal of Immunological Methods. 260:251-261

In this study, we report the exact localization and substitutional characterization of a B-cell epitope domain at the N-terminus of the preS2 region of the hepatitis B surface antigen. A set of deletion variants containing preS2 sequences of differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3feb06ad1998685846d65f6815fa8f
https://doi.org/10.1016/s0022-1759(01)00551-8

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Characterization of the reactivity pattern of murine monoclonal antibodies against wild-type hepatitis B surface antigen to g145r and other naturally occurring 'a' loop escape mutations

Autor: Guido N. J. Tytgat, Jan B.M.J. Jansen, Pauline de Wit, C. M. G. Sunnen, Rene H. M. te Morsche, Mark H. Van Roosmalen, W. P. Paulij, M. P. Cooreman, Esther M. E. Schoondermark-van de Ven

Publikováno v: Hepatology. 30:1287-1292

The hepatitis B surface antigen (HBsAg) "a" domain harbors major B-cell epitopes. Viruses with mutations in this region emerge after vaccination or during hepatitis B immune globulin (HBIg) prophylaxis. A strain with G145R replacement has been almost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f3d30439d423043cf0a598afa3d6402
https://doi.org/10.1002/hep.510300508

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Anti-HBs after hepatitis B immunization with plasma-derived and recombinant DNA-derived vaccines: binding to mutant HBsAg

Autor: R. A. Heijtink, M. H. van Roosmalen, W. P. Paulij, A.D.M.E. Osterhaus, P. van Bergen, C. M. G. Sunnen, Solko W. Schalm

Publikováno v: Vaccine, 19, 3671-3680. Elsevier

The G145R mutant of the small S-protein is a major escape mutant of hepatitis B virus observed in natural infection, after immunization and HBIG therapy. In a previous study we found that plasma-derived and recombinant DNA-derived vaccine HBsAg react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2d3a55bda7e5919e920023959ff7e1
https://pubmed.ncbi.nlm.nih.gov/11395201

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Localization of a unique hepatitis B virus epitope sheds new light on the structure of hepatitis B virus surface antigen

Autor: P. L. M. de Wit, A. Petersen-van Ettekoven, R. A. Heijtink, M. H. van Roosmalen, C. M. G. Sunnen, W. P. Paulij, M. P. Cooreman

Publikováno v: Journal of General Virology, 80, 2121-2126. Microbiology Society

In a search for monoclonal antibodies (MAbs) that can bind hepatitis B virus surface antigen (HBsAg) with amino acid substitutions in the immune dominant ‘a’ region (escape mutants) we investigated the epitope recognition site of the human MAb 4-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70688dbe1b292e0de0a99b8ea5633b5c
https://pure.eur.nl/en/publications/e51eb8ee-f2c2-490b-b895-66aff8d0552f