Zobrazeno 1 - 10
of 53
pro vyhledávání: '"C. M. Doerschuk"'
Autor:
Kerry L. Sanders, Jeff W. Hott, Robert D. Van Horn, Najmunnisa Nasreen, Joyce Hardwick, Veena B. Antony, C. M. Doerschuk, Kamal A. Mohammed
Publikováno v:
The Journal of Infectious Diseases. 183:1638-1645
Migration of polymorphonuclear neutrophils (PMNL) from the vascular compartment into the pleural space occurs rapidly during the development of parapneumonic effusions. This study investigated the polarized secretion of interleukin (IL)-8 in activate
Autor:
N A Doyle, C M Doerschuk, Daniel C. Bullard, Arthur L. Beaudet, Klaus Ley, E J Kunkel, Hiroshi Kubo, M J Hicks, Isabel Lorenzo
Publikováno v:
The Journal of Experimental Medicine
During the initial phase of the inflammatory response, leukocytes marginate and roll along the endothelial surface, a process mediated largely by the selectins and their ligands. Mice with mutations in individual selectins show no spontaneous disease
Autor:
C. M. Doerschuk, James C. Hogg
Publikováno v:
Annual Review of Physiology. 57:97-114
An adult human with a cardiac output of 5 liters/min pumps approximately 7200 liters of blood through the pulmonary circulation in 24 h. An additional 1 % of the cardiac output (72 liters over 24 h) flows through the bronchial circulation to supply t
Publikováno v:
The Journal of Immunology. 155:2775-2783
The immunologic and histologic changes associated with lung allograft rejection are believed to result from the presentation of donor lung alloantigens to recipient lymphocytes resulting in up-regulated Th1 lymphocyte activity. The ability of allogen
Autor:
A R Burns, C M Doerschuk
Publikováno v:
The Journal of Immunology. 153:3177-3188
In the systemic circulation, the leukocyte adhesion molecule, L-selectin facilitates the initial adhesion of the neutrophil to the inflamed endothelium, whereas CD11/CD18 is essential to transendothelial migration. Previous work from our laboratory s
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 9:82-89
Previous studies have shown that polymorphonuclear leukocytes (PMN) are delayed in the pulmonary capillaries by the presence of cigarette smoke. To determine if the PMN delayed by smoking are activated, we estimated the in vivo expression of CD11/CD1
Publikováno v:
Journal of Applied Physiology. 74:3040-3045
Neutrophils [polymorphonuclear leukocytes (PMNs)] are sequestrated in the lung capillary bed because PMNs are delayed with respect to red blood cells (RBCs) as they pass through these microvessels. The present study examines circulating PMN size in r
Publikováno v:
Journal of Applied Physiology. 73:1370-1376
Intravascular infusion of inflammatory mediators causes a sudden neutropenia due to the sequestration of polymorphonuclear leukocytes (PMN) within the microvasculature of the lung and other organs. This sequestration could be due to a decrease in the
Publikováno v:
American Review of Respiratory Disease. 146:190-195
Recent studies from our laboratory show that the lung contains a marginated pool of monocytes. The present study was designed to investigate monocyte accumulation in this pool 4 to 28 h after a single dose of endotoxin when the endotoxin had disappea
Autor:
Julian Solway, L. E. Alger, S. Eappon, C. Hernandez, Allan Garland, C. M. Doerschuk, M. Jackson, D. W. Ray
Publikováno v:
Scopus-Elsevier
Isocapnic dry gas hyperpnea causes bronchoconstriction in guinea pigs that is mediated by release of tachykinins from airway sensory nerves. Exogenous neuropeptides can induce microvascular leak. Therefore we tested whether dry gas hyperpnea also eli