Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

Autor: Donald E. Ingber, H. Feldmann, Kyle Rosenke, César Muñoz-Fontela, Joana Rocha-Pereira, Pierre Stéphane Gsell, Matthew B. Frieman, Simon G. P. Funnell, Kai Dallmeier, Suzanne J.F. Kaptein, E. de Wit, Johan Neyts, Leen Delang, R. Le Grand, Pauline Maisonnasse, W. E. Dowling, G. A. Hamilton, C. M. Coleman

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-4 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.4253. ⟨10.1038/s41467-020-17907-w⟩
Nature Communications, 2020, 11 (1), pp.4253. ⟨10.1038/s41467-020-17907-w⟩

There is an urgent need for drugs, therapies and vaccines to be available to protect the human population against COVID-19. One of the first approaches taken in the COVID-19 global response was to consider repurposing licensed drugs. This commentary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14560b8e4395d47e97fecb3e239be3c2
https://doaj.org/article/16f0fbaa1ef74b81ae8f7a0d0a46c7fa

Effects of increasing levels of dried corn distillers grains with solubles on growth performance, carcass characteristics, and meat quality of yearling heifers1

Autor: C. M. Coleman, James J. Higgins, James S. Drouillard, Brandon E. Depenbusch

Publikováno v: Journal of Animal Science. 87:2653-2663

Three hundred forty-seven crossbred heifers (330 +/- 11 kg initial BW) were used in a randomized complete block study to identify the optimal level of dried corn distillers grains with solubles (DGS) in flaked corn finishing diets. Fifty-four pens we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8330f2681dc1ab3bd4dac5f6d4dda691
https://doi.org/10.2527/jas.2008-1496

A Mutation in Human Keratin K6b Produces a Phenocopy of the K17 Disorder Pachyonychia Congenita Type 2

Autor: Jouni Uitto, Marcel F. Jonkman, H. Van Goor, C. M. Coleman, Whi McLean, S. P. Covello, Fjd Smith

Publikováno v: Human Molecular Genetics, 7(7), 1143-1148. Oxford University Press

Type I and type II keratins form the heteropolymeric intermediate filament cytoskeleton, which is the main stress-bearing structure within epithelial cells. Pachyonychia congenita (PC) is a group of autosomal dominant disorders whose most prominent p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534106c2540994ef0c4b8b3ff0c283f9
https://doi.org/10.1093/hmg/7.7.1143

A novel mutation in KRT12 associated with Meesmann's epithelial corneal dystrophy

Autor: Fjd Smith, Graeme C.M. Black, Whi McLean, S J Morgan, Alan D. Irvine, J H McCarthy, Johnny Moore, C. M. Coleman, Ole Swensson

Publikováno v: The British journal of ophthalmology. 86(7)

Background: The molecular basis of Meesmann9s epithelial corneal dystrophy (MECD) has recently been attributed to mutations in the cornea specific keratin genes KRT3 and KRT12. The mechanisms by which these mutations cause the Meesmann9s phenotype ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642d8c21b9b74e1e218f305b25943152
https://pubmed.ncbi.nlm.nih.gov/12084738

Epidermolytic palmoplantar keratoderma due to a novel type of keratin mutation, a 3-bp insertion in the keratin 9 helix termination motif

Autor: Jouni Uitto, Colin S. Munro, C. M. Coleman, Whi McLean, Fjd Smith

Publikováno v: The British journal of dermatology. 140(3)

Epidermolytic palmoplantar keratoderma (EPPK) is an autosomal dominant genodermatosis characterized by diffuse keratoderma, typically with an erythematous border. Histologically, palmoplantar epidermis shows suprabasal cytolysis and ultrastructurally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ebe672931aa266b0d77e6d9e89a473
https://pubmed.ncbi.nlm.nih.gov/10233272