Výsledky vyhledávání - "C. M. CHAVEZ"

Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques

Autor: T A, Baillie, R A, Halpin, B K, Matuszewski, L A, Geer, C M, Chavez-Eng, D, Dean, M, Braun, G, Doss, A, Jones, T, Marks, D, Melillo, K P, Vyas

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(12)

Rofecoxib is a potent and highly selective cyclooxygenase-2 inhibitor used for the treatment of osteoarthritis and pain. Following administration of [4-(14)C]rofecoxib to intact rats, the plasma C(max) (at approximately 1 h) was followed by a seconda

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef37db0a8740c37d4c22a634cea01417
https://pubmed.ncbi.nlm.nih.gov/11717181

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Matrix effect in quantitative LC/MS/MS analyses of biological fluids: a method for determination of finasteride in human plasma at picogram per milliliter concentrations

Autor: B K, Matuszewski, M L, Constanzer, C M, Chavez-Eng

Publikováno v: Analytical chemistry. 70(5)

Contrary to common perceptions, the reliability of quantitative assays for the determination of drugs in biological fluids using high-performance liquid chromatography with tandem mass spectrometric (LC/MS/MS) detection methods and the integrity of r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96b013e415aa52405728fa405a43bbea
https://pubmed.ncbi.nlm.nih.gov/9511465

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Differences among raters evaluating the success of EMLA cream in alleviating procedure-related pain in children with cancer

Autor: M T, Holdsworth, D W, Raisch, S S, Winter, C M, Chavez, M M, Leasure, M H, Duncan

Publikováno v: Pharmacotherapy. 17(5)

We evaluated the analgesic efficacy of EMLA cream after repeated bone marrow aspirations or lumbar punctures (LPs) in children with cancer, and compared the ratings among patients, their parents, physicians, and nurses. Data from LPs were analyzed at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::069b947e146bae589922f133012a34ec
https://pubmed.ncbi.nlm.nih.gov/9324191

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Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men

Autor: E C Shamblen, S J Justice, Gregory A. Winchell, C M Chavez, Daniel Z. Wang, K. C. Lasseter, David L. Ebel, A. Van Hecken, I De Lepeleire, M L Constanzer, Jules I. Schwartz, Barry J. Gertz, P. J. De Schepper

Publikováno v: The Journal of clinical endocrinology and metabolism. 81(8)

Two isozymes (types 1 and 2) of 5 alpha-reductase (5 alpha R; EC 1.3.99.5), with differential tissue distribution, have been identified in humans. These enzymes catalyze the reduction of testosterone (T) to dihydrotestosterone (DHT). The contribution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4765b881561dc7d717399590815cbf0
https://pubmed.ncbi.nlm.nih.gov/8768856

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Septicemia secondary to impacted infected pacemaker wire. Successful treatment by removal with cardiopulmonary bypass

Autor: C M, Chavez, J H, Conn

Publikováno v: The Journal of thoracic and cardiovascular surgery. 73(5)

Infection of an intravenous pacemaker electrode developed in a 78-year-old man after multiple replacements and revisions of the pulse generator and the pacemaker lead. Spread of the infective process to the endocardium was followed by septicemia with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c1c29ee63836aede37dddd6f96eaf7c6
https://pubmed.ncbi.nlm.nih.gov/321883

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