Zobrazeno 1 - 10
of 188
pro vyhledávání: '"C. Lepore"'
Publikováno v:
Weather and Climate Dynamics, Vol 3, Pp 1063-1075 (2022)
El Niño–Southern Oscillation (ENSO) modulates severe thunderstorm activity in the US, with increased activity expected during La Niña conditions. There is also evidence that severe thunderstorm activity is influenced by the Arctic Oscillation (AO
Externí odkaz:
https://doaj.org/article/b63a269ba1824cb4952ede9390a7baf9
Publikováno v:
Hydrology and Earth System Sciences, Vol 17, Iss 9, Pp 3371-3387 (2013)
This paper presents the development of a rainfall-triggered landslide module within an existing physically based spatially distributed ecohydrologic model. The model, tRIBS-VEGGIE (Triangulated Irregular Networks-based Real-time Integrated Basin Simu
Externí odkaz:
https://doaj.org/article/d1b9bc0519724dc6b2c833de360de354
Autor:
Mark W Urban, Brittany A Charsar, Nicolette M Heinsinger, Shashirekha S Markandaiah, Lindsay Sprimont, Wei Zhou, Eric V Brown, Nathan T Henderson, Samantha J Thomas, Biswarup Ghosh, Rachel E Cain, Davide Trotti, Piera Pasinelli, Megan C Wright, Matthew B Dalva, Angelo C Lepore
Publikováno v:
eLife, Vol 12 (2024)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss. Importantly, non-neuronal cell types such as astrocytes also play significant roles in disease pathogenesis. However, mechanisms of astrocyte contr
Externí odkaz:
https://doaj.org/article/018e0a8bf2cb4c7db4d6c298aaf9f962
Autor:
Joshua R. Barton, Annie K. Londregan, Tyler D. Alexander, Ariana A. Entezari, Shely Bar-Ad, Lan Cheng, Angelo C. Lepore, Adam E. Snook, Manuel Covarrubias, Scott A. Waldman
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Visceral pain (VP) is a global problem with complex etiologies and limited therapeutic options. Guanylyl cyclase C (GUCY2C), an intestinal receptor producing cyclic GMP(cGMP), which regulates luminal fluid secretion, has emerged as a therapeutic targ
Externí odkaz:
https://doaj.org/article/6fcd4bf1e4cf498abeccb887b46d04f2
Publikováno v:
Cells, Vol 12, Iss 11, p 1519 (2023)
High spinal cord injuries (SCIs) lead to permanent functional deficits, including respiratory dysfunction. Patients living with such conditions often rely on ventilatory assistance to survive, and even those that can be weaned continue to suffer life
Externí odkaz:
https://doaj.org/article/b8031f1dc04c4deba137d8a448d50fb1
Autor:
K. Supriya, Chris Mead, Ariel D. Anbar, Joshua L. Caulkins, James P. Collins, Katelyn M. Cooper, Paul C. LePore, Tiffany Lewis, Amy Pate, Rachel A. Scott, Sara E. Brownell
Publikováno v:
Frontiers in Education, Vol 6 (2021)
Institutions across the world transitioned abruptly to remote learning in 2020 due to the COVID-19 pandemic. This rapid transition to remote learning has generally been predicted to negatively affect students, particularly those marginalized due to t
Externí odkaz:
https://doaj.org/article/8317271deb284a8daf15a201e740846b
Autor:
Lan Cheng, Armin Sami, Biswarup Ghosh, Hannah J. Goudsward, George M. Smith, Megan C. Wright, Shuxin Li, Angelo C. Lepore
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105389- (2021)
Promoting the combination of robust regeneration of damaged axons and synaptic reconnection of these growing axon populations with appropriate neuronal targets represents a major therapeutic goal following spinal cord injury (SCI). A key impediment t
Externí odkaz:
https://doaj.org/article/07cfdaa0d5654a6b81d0e28709692bdb
Autor:
Biswarup Ghosh, Jia Nong, Zhicheng Wang, Mark W. Urban, Nicolette M. Heinsinger, Victoria A. Trovillion, Megan C. Wright, Angelo C. Lepore, Yinghui Zhong
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 591-604 (2019)
We tested a biomaterial-based approach to preserve the critical phrenic motor circuitry that controls diaphragm function by locally delivering minocycline hydrochloride (MH) following cervical spinal cord injury (SCI). MH is a clinically-available an
Externí odkaz:
https://doaj.org/article/7aceb4f3d7b04b1c9cce4afadb09635c
Autor:
Lan Cheng, Armin Sami, Biswarup Ghosh, Mark W. Urban, Nicolette M. Heinsinger, Sophia S. Liang, George M. Smith, Megan C. Wright, Shuxin Li, Angelo C. Lepore
Publikováno v:
Neurobiology of Disease, Vol 147, Iss , Pp 105153- (2021)
Chondroitin sulfate proteoglycans (CSPGs), up-regulated in and around the lesion after traumatic spinal cord injury (SCI), are key extracellular matrix inhibitory molecules that limit axon growth and consequent recovery of function. CSPG-mediated inh
Externí odkaz:
https://doaj.org/article/8f970bd3288448ba90f5bc173ddf07a0
Autor:
R. Vivian Allahyari, Nicolette M. Heinsinger, Daniel Hwang, David A. Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J. Thomas, Theodore J. Price, Abdolmohamad Rostami, Angelo C. Lepore
Publikováno v:
Cells, Vol 11, Iss 4, p 721 (2022)
There is growing appreciation for astrocyte heterogeneity both across and within central nervous system (CNS) regions, as well as between intact and diseased states. Recent work identified multiple astrocyte subpopulations in mature brain. Interestin
Externí odkaz:
https://doaj.org/article/f3c9b73e7f55416d9c08ca3be6b96d78