Zobrazeno 1 - 10
of 335
pro vyhledávání: '"C. Leake"'
Autor:
Lara G. Dresser, Casper Kunstmann-Olsen, Donato Conteduca, Christopher M. Hofmair, Nathan Smith, Laura Clark, Steven Johnson, J. Carlos Penedo, Mark C. Leake, Steven D. Quinn
Publikováno v:
Communications Materials, Vol 5, Iss 1, Pp 1-12 (2024)
Abstract Detergent-induced vesicle interactions, critical for applications including virus inactivation, varies according to the detergent type and membrane composition, but the underlying mechanistic details remain underexplored. Here, we use a lipi
Externí odkaz:
https://doaj.org/article/cde95aa41d094f1389f0e3b340e81395
Autor:
Jack W. Shepherd, Sebastien Guilbaud, Zhaokun Zhou, Jamieson A. L. Howard, Matthew Burman, Charley Schaefer, Adam Kerrigan, Clare Steele-King, Agnes Noy, Mark C. Leake
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Biopolymer topology is critical for determining interactions inside cell environments, exemplified by DNA where its response to mechanical perturbation is as important as biochemical properties to its cellular roles. The dynamic structures o
Externí odkaz:
https://doaj.org/article/7db654a7a24440c7a4597f05ffd56ce8
Autor:
Dominique C.S. Evans, Amanda B. Khamas, Alex Payne-Dwyer, Adam J.M. Wollman, Kristian S. Rasmussen, Janne K. Klitgaard, Birgitte Kallipolitis, Mark C. Leake, Rikke L. Meyer
Publikováno v:
Biofilm, Vol 8, Iss , Pp 100233- (2024)
The major human pathogen Staphylococcus aureus forms biofilms comprising of a fibrin network that increases attachment to surfaces and shields bacteria from the immune system. It secretes two coagulases, Coagulase (Coa) and von Willebrand factor bind
Externí odkaz:
https://doaj.org/article/d950255ce3c94156a393ac185af24026
Autor:
Dominique C. S. Evans, Amanda B. Khamas, Lisbeth Marcussen, Kristian S. Rasmussen, Janne K. Klitgaard, Birgitte H. Kallipolitis, Janni Nielsen, Daniel E. Otzen, Mark C. Leake, Rikke L. Meyer
Publikováno v:
Microbial Cell, Vol 10, Iss 7, Pp 145-156 (2023)
Staphylococcus aureus is a major human pathogen that utilises many surface-associated and secreted proteins to form biofilms and cause disease. However, our understanding of these processes is limited by challenges of using fluores-cent protein repor
Externí odkaz:
https://doaj.org/article/51cdcdeead1b4d71959554d9bbf38cf9
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5264-5274 (2022)
The integration host factor (IHF) is a prominent example of indirect readout as it imposes one of the strongest bends on relaxed linear DNA. However, the relation between IHF and torsionally constrained DNA, as occurs physiologically, remains unclear
Externí odkaz:
https://doaj.org/article/04956f119e9247879e540c6867ee53d7
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105675- (2022)
Summary: The ability of tumors to establish a pro-tumorigenic microenvironment is an important point of investigation in the search for new therapeutics. Tumors form microenvironments in part by the “education” of immune cells attracted via chemo
Externí odkaz:
https://doaj.org/article/c95b28ec4d9a499896bfde69dec8b93e
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Lipid vesicles are valuable mesoscale molecular confinement vessels for studying membrane mechanics and lipid–protein interactions, and they have found utility among bio-inspired technologies, including drug delivery vehicles. While vesicle morphol
Externí odkaz:
https://doaj.org/article/a090bd6f46a54de6b8f795639729ea76
Autor:
Mark C. Leake
Recent advances in single molecule science have presented a new branch of science: single molecule cellular biophysics, combining classical cell biology with cutting-edge single molecule biophysics. This textbook explains the essential elements of th
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4049-4058 (2021)
As camera pixel arrays have grown larger and faster, and optical microscopy techniques ever more refined, there has been an explosion in the quantity of data acquired during routine light microscopy. At the single-molecule level, analysis involves mu
Externí odkaz:
https://doaj.org/article/e818b14a467e4b4d9e57f197a09aa9ce
Autor:
Jason Cosgrove, Mario Novkovic, Stefan Albrecht, Natalia B. Pikor, Zhaoukun Zhou, Lucas Onder, Urs Mörbe, Jovana Cupovic, Helen Miller, Kieran Alden, Anne Thuery, Peter O’Toole, Rita Pinter, Simon Jarrett, Emily Taylor, Daniel Venetz, Manfred Heller, Mariagrazia Uguccioni, Daniel F. Legler, Charles J. Lacey, Andrew Coatesworth, Wojciech G. Polak, Tom Cupedo, Bénedicte Manoury, Marcus Thelen, Jens V. Stein, Marlene Wolf, Mark C. Leake, Jon Timmis, Burkhard Ludewig, Mark C. Coles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes
Externí odkaz:
https://doaj.org/article/a29fe9ea7a8d465093c19a3301a148f3