Zobrazeno 1 - 10
of 272
pro vyhledávání: '"C. Laurenti"'
Autor:
Marcello C. Laurenti, Praveer Arora, Chiara Dalla Man, James C. Andrews, Robert A. Rizza, Aleksey Matveyenko, Kent R. Bailey, Claudio Cobelli, Adrian Vella
Publikováno v:
Physiological Reports, Vol 10, Iss 13, Pp n/a-n/a (2022)
Abstract Abnormal postprandial suppression of glucagon in Type 2 diabetes (T2DM) has been attributed to impaired insulin secretion. Prior work suggests that insulin and glucagon show an inverse coordinated relationship. However, dysregulation of α
Externí odkaz:
https://doaj.org/article/47de651730664b97a1c702f3f237b300
Autor:
Jon D, Adams, Aoife M, Egan, Marcello C, Laurenti, Daniel, Schembri Wismayer, Kent R, Bailey, Claudio, Cobelli, Chiara, Dalla Man, Adrian, Vella
Publikováno v:
Metabolic syndrome and related disorders. 20(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7c9b5b05d2abbca4c86621c427fe603
https://pubmed.ncbi.nlm.nih.gov/35442800
https://pubmed.ncbi.nlm.nih.gov/35442800
Publikováno v:
Metabolites, Vol 11, Iss 7, p 409 (2021)
Pancreatic β-cells are responsible for the synthesis and exocytosis of insulin in response to an increase in circulating glucose. Insulin secretion occurs in a pulsatile manner, with oscillatory pulses superimposed on a basal secretion rate. Insulin
Externí odkaz:
https://doaj.org/article/7e2f5bd2a5df4027b128aa007a433a77
Autor:
Jon D. Adams, Aoife M. Egan, Marcello C. Laurenti, Daniel Schembri Wismayer, Kent R. Bailey, Claudio Cobelli, Chiara Dalla Man, Adrian Vella
Publikováno v:
Metabolic Syndrome and Related Disorders. 20:329-335
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d683aec33710ddcf23b80bf562a6c24e
https://doi.org/10.1089/met.2021.0136
https://doi.org/10.1089/met.2021.0136
Autor:
Jacob D. Kohlenberg, Marcello C. Laurenti, Aoife M. Egan, Daniel Schembri Wismayer, Kent R. Bailey, Claudio Cobelli, Chiara Dalla Man, Adrian Vella
People with isolated impaired fasting glucose (IFG) have normal beta cell function. We hypothesised that an increased glucose threshold for beta cell secretion explains IFG.We used graded glucose infusion to examine the relationship of insulin secret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4a5664826d7f95e9f2d8872747a1e4
https://hdl.handle.net/11577/3471561
https://hdl.handle.net/11577/3471561
Autor:
Claudio Cobelli, Daniel J. Schembri Wismayer, Marcello C. Laurenti, Adrian Vella, Aoife M. Egan, Chiara Dalla Man, Kent R. Bailey, J D Adams
Publikováno v:
Am J Physiol Endocrinol Metab
Type 2 diabetes is a disease characterized by impaired insulin secretion and defective glucagon suppression in the postprandial period. We examined the effect of impaired glucagon suppression on glucose concentrations and endogenous glucose productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70dd18003f183eb44c5e708056bbad2
https://doi.org/10.1152/ajpendo.00284.2021
https://doi.org/10.1152/ajpendo.00284.2021
Autor:
Vinaya Simha, John D. Port, Claudio Cobelli, Ivan Vuckovic, Katherine A. Klaus, Ian R. Lanza, Nathan Le Brasseur, Surendra Dasari, K. Sreekumaran Nair, Marcello C. Laurenti
Publikováno v:
J Clin Endocrinol Metab
Context Familial partial lipodystrophy (FPL), Dunnigan variety is characterized by skeletal muscle hypertrophy and insulin resistance besides fat loss from the extremities. The cause for the muscle hypertrophy and its functional consequences is not k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c26ac528ae3793dffc68316265e60f
https://doi.org/10.1210/clinem/dgab725
https://doi.org/10.1210/clinem/dgab725
Autor:
Rahele A. Farahani, Aoife M. Egan, Andrew A. Welch, Marcello C. Laurenti, Claudio Cobelli, Chiara Dalla Man, Adrian Vella
Publikováno v:
Diabetes.
Data from transgenic rodent models suggest that glucagon acts as an insulin secretagogue by signalling through the Glucagon-Like Peptide-1 Receptor (GLP1R) present on β-cells. However, its net contribution to physiologic insulin secretion in humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c2866e92fd475c45a6e4b84dacc8f9
https://pubmed.ncbi.nlm.nih.gov/36562995
https://pubmed.ncbi.nlm.nih.gov/36562995
Autor:
ANDREW A. WELCH, DANIEL SCHEMBRI WISMAYER, AOIFE M. EGAN, RAHELE A. FARAHANI, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA
Publikováno v:
Diabetes. 71
Individuals with prediabetes can be classified by fasting and glucose tolerance status. Previously we observed that elevated fasting Free Fatty Acids (FFA) are associated with Impaired Glucose Tolerance (IGT) and decreased β-cell function (quantifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b0a02a022f8af157aa2f889915257cd
https://doi.org/10.2337/db22-1325-p
https://doi.org/10.2337/db22-1325-p
Autor:
RAHELE A. FARAHANI, AOIFE M. EGAN, ANDREW A. WELCH, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA
Publikováno v:
Diabetes. 71
Data from transgenic rodent models suggest that glucagon acts as an insulin secretagogue by signalling through the Glucagon-Like Peptide-1 Receptor (GLP1R) present on β-cells. This occurs at high concentrations as are present within the islet. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15f314703387e1bd12297f64871cd04e
https://doi.org/10.2337/db22-358-or
https://doi.org/10.2337/db22-358-or